2022
DOI: 10.21203/rs.3.rs-1438842/v1
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Genome-wide mapping of oncogenic pathways and genetic modifiers of chemotherapy using a high-risk hepatoblastoma genetic model

Abstract: A lack of relevant genetic models and cell lines hampers our understanding of hepatoblastoma pathogenesis and the development of new therapies for this neoplasm. We report a liver-specific MYC-driven hepatoblastoma murine model that faithfully recapitulates the pathological features of mixed fetal and embryonal hepatoblastoma, with transcriptomics resembling the high-risk gene signatures of the human disease. Single-cell RNA-sequencing and spatial transcriptomics identified distinct subpopulations of hepatobl… Show more

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Cited by 2 publications
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“…PRKDC knockout was identified as the most potent sensitizer to doxorubicin (Fig. 3a), an association recently also reported in hepatoblastoma 34 and others 35,36 , and a hit which we explore further in a subsequent subsection. BCL2L1 knockout was the top-ranked sensitizer for cisplatin (Fig.…”
Section: A Hierarchical Bayesian Model Can Identify Gene Knockouts Th...mentioning
confidence: 64%
“…PRKDC knockout was identified as the most potent sensitizer to doxorubicin (Fig. 3a), an association recently also reported in hepatoblastoma 34 and others 35,36 , and a hit which we explore further in a subsequent subsection. BCL2L1 knockout was the top-ranked sensitizer for cisplatin (Fig.…”
Section: A Hierarchical Bayesian Model Can Identify Gene Knockouts Th...mentioning
confidence: 64%