Genome-wide screening of functional long noncoding RNAs in the epicardial adipose tissues of atrial fibrillation

Shi, Xin; Shao, Xuelian; Liu, Ban; Lv, Mengwei; Pandey, Pratik; Guo, Changfa; Zhang, Ruilin; Zhang, Yangyang

doi:10.1016/j.bbadis.2020.165757

Cited by 28 publications

(22 citation statements)

References 26 publications

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“…In most cases, either right or left atrial appendages were analysed [ 175 , 176 , 177 , 178 , 179 , 180 ], but in some cases right and left atrial samples were pooled together [ 179 , 180 , 181 ], while in other blood samples [ 180 , 183 ] or epicardial adipose tissue [ 184 , 185 ] were analysed. Given the wide variability of biological conditions studied, it is then not surprising that comparative analyses of these lncRNA transcriptomic analyses revealed no common AF signature [ 186 ]. Importantly, concurrent analyses of differentially expressed mRNAs and/or microRNAs and more recently circular RNAs (circRNAs) have provided additional insights into the plausible gene regulatory networks involved in AF [ 177 , 178 , 184 , 187 ].…”

Section: Epigenetics Of Atrial Fibrillationmentioning

confidence: 99%

Genetics and Epigenetics of Atrial Fibrillation

Lozano-Velasco

Franco

Aránega

et al. 2020

IJMS

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Atrial fibrillation (AF) is known to be the most common supraventricular arrhythmia affecting up to 1% of the general population. Its prevalence exponentially increases with age and could reach up to 8% in the elderly population. The management of AF is a complex issue that is addressed by extensive ongoing basic and clinical research. AF centers around different types of disturbances, including ion channel dysfunction, Ca2+-handling abnormalities, and structural remodeling. Genome-wide association studies (GWAS) have uncovered over 100 genetic loci associated with AF. Most of these loci point to ion channels, distinct cardiac-enriched transcription factors, as well as to other regulatory genes. Recently, the discovery of post-transcriptional regulatory mechanisms, involving non-coding RNAs (especially microRNAs), DNA methylation, and histone modification, has allowed to decipher how a normal heart develops and which modifications are involved in reshaping the processes leading to arrhythmias. This review aims to provide a current state of the field regarding the identification and functional characterization of AF-related epigenetic regulatory networks

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Section: Epigenetics Of Atrial Fibrillationmentioning

confidence: 99%

Genetics and Epigenetics of Atrial Fibrillation

Lozano-Velasco

Franco

Aránega

et al. 2020

IJMS

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“…TGF-β signaling plays a key role in various kinds of diseases, including malignant tumors ( 36 , 37 ). It has been reported that TGF-β can activate Smad2 and Smad3 ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Knockdown of lncRNA LINC01234 Suppresses the Tumorigenesis of Liver Cancer via Sponging miR-513a-5p

Song

et al. 2020

Front. Oncol.

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Background: Liver cancer is a frequent malignancy with poor prognosis and high mortality all over the world. It has been reported many lncRNAs could modulate the tumorigenesis of liver cancer. To identify novel potential targets for liver cancer, the differential expressed lncRNAs between liver cancer and adjacent normal tissues was analyzed with bioinformatics tool. Methods: The differential expressed lncRNAs between liver cancer and adjacent normal tissues were analyzed with bioinformatics tool. Cell viability and proliferation was tested by CCK8 and Ki67, respectively. Apoptosis of liver cancer cells was tested by flow cytometry. Gene and protein expressions in liver cancer cells were measured by qRT-PCR and western blot, respectively. In vivo model of liver cancer was established to detect the effect of LINC01234 on liver cancer in vivo. Results: LINC01234 was found to be negatively correlated with the survival rate of patients with liver cancer. Moreover, knockdown of LINC01234 significantly suppressed the proliferation and invasion of liver cancer cells via inducing the apoptosis. Meanwhile, miR-513a-5p was sponged by LINC01234, and USP4 was found to be a direct target of miR-513a-5p. In addition, LINC01234 knockdown inhibited the tumorigenesis of liver cancer via inactivating TGF-β signaling. Furthermore, silencing of LINC01234 notably inhibited the tumor growth of liver cancer in vivo. Conclusion: Downregulation of LINC01234 could inhibit the tumorigenesis of liver cancer via mediation of miR-513a-5p/USP4/TGF-β axis. Thus, LINC01234 might serve as a new target for the treatment of liver cancer.

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“…TGF-β signaling plays a key role in various kinds of diseases, including malignant tumors (36,37). It has been reported that TGF-β can activate Smad2 and Smad3 (38).…”

Section: Discussionmentioning

confidence: 99%

Knockdown of lncRNA LINC01234 suppresses the tumorigenesis of liver cancer via sponging miR-513a-5p

Song

et al. 2020

Preprint

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Background Liver cancer is a frequent malignancy with poor prognosis. It has been reported that many lncRNAs could regulate the progression of liver cancer. To identify potential therapeutic targets for liver cancer, we conducted bioinformatics analysis of lncRNAs in tumor tissues and adjacent normal tissues. Methods The differential expression of lncRNAs between liver cancer tissues and adjacent normal tissues were examined by bioinformatics analysis. Cell proliferation was tested by CCK-8. Cell apoptosis in liver cancer was detected by flow cytometry. Gene and protein expression in liver cancer cells were measured by q-PCR and Western-blot, respectively. Xenograft tumor model was established to verify the function of LNC01234 on liver cancer in vivo. Results LNC01234 was found to be notably upregulated in liver cancer tissues. In addition, knockdown of LNC01234 significantly inhibited the proliferation, invasion and induced the apoptosis of liver cancer cells. Meanwhile, miR-513a-5p was a downstream target of LNC01234 and USP4 was a direct target of miR-513a-5p. Moreover, downregulation of LNC01234 inhibited the tumorigenesis of liver cancer via inactivating TGF-β signaling. Conclusion Downregulation of LNC01234 could inhibit the progression of liver cancer, which may serve as a potential novel target for treatment of liver cancer.

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Genome-wide screening of functional long noncoding RNAs in the epicardial adipose tissues of atrial fibrillation

Cited by 28 publications

References 26 publications

Genetics and Epigenetics of Atrial Fibrillation

Genetics and Epigenetics of Atrial Fibrillation

Knockdown of lncRNA LINC01234 Suppresses the Tumorigenesis of Liver Cancer via Sponging miR-513a-5p

Knockdown of lncRNA LINC01234 suppresses the tumorigenesis of liver cancer via sponging miR-513a-5p

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