Genome-wide transcriptional profiling of pulmonary functional sequelae in ARDS- secondary to SARS-CoV-2 infection

García-Hidalgo, María C.; Peláez, Rafael Pila; González, Jessica; Santisteve, Sally; Molinero, Marta; Perez-Pons, Manel; Belmonte, Thalía; Torres, Gerard; Moncusí‐Moix, Anna; Gort‐Paniello, Clara; Aguilà, Maria; Seck, Faty; Carmona, Paola; Caballero, Jesús; Barberà, Carme; Ceccato, Adrián; Fernández-Barat, Laia; Ferrer, Ricard; Garcia-Gasulla, Darío; Lorente-Balanza, Jose Ángel; Menéndez, Rosário; Motos, Ana; Peñuelas, Óscar; Riera, Jordi; Bermejo-Martín, Jesús F.; Torres, Antoni; Barbé, Ferrán; Gonzalo‐Calvo, David de; Larráyoz, Ignacio M.

doi:10.1016/j.biopha.2022.113617

Cited by 7 publications

(3 citation statements)

References 56 publications

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“…Additionally, some studies have shown that higher CD8 + T cells were related to a reduced risk for COVID-19 and more CD8 + T cells were predominated in mild patients not in severe patients [ 31 , 32 ]. More recently, a machine learning analysis suggested resting NK cells were the most significant predictor of severity of COVID-19 [ 33 ]. Neutrophils were often regarded as a monitor for severe symptom of COVID-19 and are also more likely to be targeted therapeutic cells [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

Landscape of infiltrated immune cell characterization in COVID-19

Zheng,

Zhang,

Lai

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Landscape of infiltrated immune cell characterization in COVID-19

Zheng,

Zhang,

Lai

et al. 2024

Heliyon

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“…GAS2 can promote cell senescence [93]. The whole-blood transcriptome profile revealed decreased expression of GAS2 in patients with severe diffusion impairment [94]. Decreased GAS2 mRNA could be a consequence of GAS2 post-transcriptional promotion (Figure 4).…”

Section: Genes/proteins Known To Be Related To Covid-19mentioning

confidence: 99%

“…Up to 80% of patients that survive acute respiratory distress syndrome (ARDS) secondary to SARS-CoV-2 infection present with persistent anomalies in pulmonary function after hospital discharge. Whole-blood transcriptome profiling revealed decreased expression of GAS2 in patients with severe diffusion impairment [94].…”

Section: Genes/proteins Identified By 1-l Transcription Of C-(aa)n-n ...mentioning

confidence: 99%

1-L Transcription of SARS-CoV-2 Spike Protein S1 Subunit

Nahalka

2024

IJMS

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The COVID-19 pandemic prompted rapid research on SARS-CoV-2 pathogenicity. Consequently, new data can be used to advance the molecular understanding of SARS-CoV-2 infection. The present bioinformatics study discusses the “spikeopathy” at the molecular level and focuses on the possible post-transcriptional regulation of the SARS-CoV-2 spike protein S1 subunit in the host cell/tissue. A theoretical protein–RNA recognition code was used to check the compatibility of the SARS-CoV-2 spike protein S1 subunit with mRNAs in the human transcriptome (1-L transcription). The principle for this method is elucidated on the defined RNA binding protein GEMIN5 (gem nuclear organelle-associated protein 5) and RNU2-1 (U2 spliceosomal RNA). Using the method described here, it was shown that 45% of the genes/proteins identified by 1-L transcription of the SARS-CoV-2 spike protein S1 subunit are directly linked to COVID-19, 39% are indirectly linked to COVID-19, and 16% cannot currently be associated with COVID-19. The identified genes/proteins are associated with stroke, diabetes, and cardiac injury.

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Inflammatory and vascular biomarkers in post‐COVID‐19 syndrome: A systematic review and meta‐analysis of over 20 biomarkers

Yong

Halim

et al. 2023

Reviews in Medical Virology

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Severe acute respiratory syndrome coronavirus 2 may inflict a post-viral condition known as post-COVID-19 syndrome (PCS) or long-COVID. Studies measuring levels of inflammatory and vascular biomarkers in blood, serum, or plasma of COVID-19 survivors with PCS versus non-PCS controls have produced mixed findings. Our review sought to meta-analyse those studies. A systematic literature search was performed across five databases until 25 June 2022, with an updated search on 1 November 2022. Data analyses were performed with Review Manager and R Studio statistical software. Twenty-four biomarkers from 23 studies were meta-analysed. Higher levels of C-reactive protein (Standardized mean difference (SMD) = 0.20; 95%

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Genome-wide transcriptional profiling of pulmonary functional sequelae in ARDS- secondary to SARS-CoV-2 infection

Cited by 7 publications

References 56 publications

Landscape of infiltrated immune cell characterization in COVID-19

Landscape of infiltrated immune cell characterization in COVID-19

1-L Transcription of SARS-CoV-2 Spike Protein S1 Subunit

Inflammatory and vascular biomarkers in post‐COVID‐19 syndrome: A systematic review and meta‐analysis of over 20 biomarkers

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