Genomewide admixture study in Mexican Mestizos with multiple sclerosis

Ordóñez, Graciela; Romero, Sandra; Orozco, Lorena; Pineda, Benjamín; Jiménez-Morales, Silvia; Nieto, A. Solano; Garcia‐Ortíz, Humberto; Sotelo, Julio

doi:10.1016/j.clineuro.2014.11.026

Cited by 21 publications

(19 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that Puerto Ricans tend to be affected by vitamin D insufficiency/deficiency despite abundant sunlight [8]. In addition, European ancestry has been shown to increase the likelihood of developing MS [28, 29]. The genetic makeup of Puerto Ricans has a higher African American and European ancestry mixture than that of Mexican Americans [30, 31].…”

Section: Discussionmentioning

confidence: 99%

Increasing Incidence and Prevalence of Multiple Sclerosis in Puerto Rico (2013–2016)

et al. 2017

View full text Add to dashboard Cite

Background: The incidence of multiple sclerosis (MS) has been increasing worldwide over the past decades. However, this upward trend has not been examined at the country level in Latin America and the Caribbean (LAC). The aims of this study are to examine trends of MS incidence over 4 years and to provide age- and gender-standardized incidence rate estimates for a Caribbean island. Methods: Data from the Puerto Rico (PR) MS Foundation’s registry was used to identify all newly diagnosed MS cases between 2013 and 2016. MS patients were 18 years and older and met the 2010 revised McDonald criteria. Age- and gender-standardized incidence rates were estimated. Results: A total of 583 new MS cases were diagnosed in PR from 2013 to 2016. The age- and gender-standardized MS incidence rate for PR increased from 6.1/100,000 in 2013 to 6.7/100,000 in 2016. The annual age-standardized MS incidence rates for females rose from 8.4/100,000 in 2013 to 9.8/100,000 in 2016 and were higher than males, which remained around 3.7/100,000. Conclusion: Incidence estimates for PR were higher than other LAC countries but consistent with MS increases in other world regions. Our findings tend to rule out several prior potential environmental explanations for high MS incidence rates.

show abstract

Section: Discussionmentioning

confidence: 99%

Increasing Incidence and Prevalence of Multiple Sclerosis in Puerto Rico (2013–2016)

et al. 2017

View full text Add to dashboard Cite

show abstract

“…MS prevalence is also high in Iran at approximately 50 per 100,000 and women are affected at approximately 3 times the rate of men. 2) The nature of this disabling disease can affect the activities and social participation of MS patients. A Germany study found that anorgasmia in women and erectile dysfunction in men are the most common problems in sexual relationships among MS patients.…”

Section: Introductionmentioning

confidence: 99%

Validity and Reliability of the World Health Organization Disability Assessment Schedule 2.0 36-Item Persian Version for Persons with Multiple Sclerosis

et al. 2020

View full text Add to dashboard Cite

Background: No previous studies have assessed the psychometric properties of the 36-item version of the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) in the Persian language of Iran. This study was designed and conducted to evaluate the validity and reliability of the Persian version using a sample of persons with multiple sclerosis in Ahvaz, Iran. Methods: The methodological study was conducted in two stages: First, the 36 items of the original WHODAS 2.0 were translated to create a Persian version, after which the translation validity and psychometric properties were tested. The factor structure of the instrument was also tested using exploratory and confirmatory factor analyses. Results: The intraclass correlation coefficients were very good to excellent, varying between 0.82 and 0.99 for the six domains, and all domains had Cronbach's α reliability values of above 0.70. For construct validity, results showed negative and strong correlation between the total score of WHODAS 2.0 and the Multiple Sclerosis Quality of Life-54. Exploratory factor analysis divided the Persian version of WHODAS 2.0 into seven factors for multiple sclerosis patients. Conclusion: The results of this study indicate that the Persian version of WHODAS 2.0 is a valid and reliable instrument to study the disabilities of people with multiple sclerosis.

show abstract

“…Nevertheless, while our study did not specifically adjust for SES, we did adjust for recruitment site intentionally to account for any potential residual confounding. Research supports that lower SES is associated with poor access to care and non‐European ancestry, and that MS risk in Hispanics is associated with greater European ancestry, then it is possible that the recruitment is biased toward those that have greater access to care, have higher SES, and greater European proportions would be expected since ON is a common presentation in Hispanics . Thus, the possibility that our results are due to SES makes it less likely and any concern for an overestimation of ON in Hispanics with high Native American ancestry biasing our results should be lessen.…”

Section: Discussionmentioning

confidence: 84%

“…Few studies have examined the relationship between global genetic ancestry (or average ancestry across the genome) and clinical characteristics of MS in admixed populations . Nevertheless, the examination of genetic ancestry in asthma and other autoimmune diseases has explained some of the genetic underpinnings behind clinical differences in ethnic groups .…”

Section: Introductionmentioning

confidence: 99%

Native ancestry is associated with optic neuritis and age of onset in hispanics with multiple sclerosis

Amezcua

Beecham

Delgado

et al. 2018

Ann Clin Transl Neurol

View full text Add to dashboard Cite

Background and ObjectiveHispanics with multiple sclerosis (MS) present younger and more often with optic neuritis (ON) as compared to Whites in the western United States. Regional differences related to Hispanic genetic admixture could be responsible. We investigated the association between global genetic ancestry and ON and age at onset of MS in Hispanics.MethodsData were obtained for 1033 self‐identified Hispanics with MS from four MS‐based registries from four academic institutions across the United States January 2016–April 2017. Multivariate regression models, utilizing genetic ancestry estimates for Native American (NA), African, and European ancestry, were used to assess the relationship between genetic ancestry and ON presentation and age of MS onset, defined as age at first symptom.ResultsGenetic ancestry and ON proportions varied by region where NA ancestry and ON proportions were highest among Hispanics in the southwestern United States (40% vs. 19% overall for NA and 38% vs. 25% overall for ON). A strong inverse correlation was observed between NA and European ancestry (r = −0.83). ON presentation was associated with younger age of onset (OR: 0.98; 95% CI: 0.96–0.99; P = 7.80 × 10−03) and increased NA ancestry (OR: 2.35 for the highest versus the lowest quartile of NA ancestry; 95% CI: 1.35–4.10; P = 2.60 × 10−03). Younger age of onset was found to be associated with a higher proportion NA (Beta: −5.58; P = 3.49 × 10−02) and African ancestry (Beta: −10.07; P = 1.39 × 10−03).InterpretationEthnic differences associated with genetic admixture could influence clinical presentation in Hispanics with MS; underscoring the importance of considering genetic substructure in future clinical, genetic, and epigenetic studies in Hispanics.

show abstract

Genomewide admixture study in Mexican Mestizos with multiple sclerosis

Cited by 21 publications

References 30 publications

Increasing Incidence and Prevalence of Multiple Sclerosis in Puerto Rico (2013–2016)

Increasing Incidence and Prevalence of Multiple Sclerosis in Puerto Rico (2013–2016)

Validity and Reliability of the World Health Organization Disability Assessment Schedule 2.0 36-Item Persian Version for Persons with Multiple Sclerosis

Native ancestry is associated with optic neuritis and age of onset in hispanics with multiple sclerosis

Contact Info

Product

Resources

About