Genomewide association analysis of growth traits in Charolais beef cattle1

Jahuey‐Martínez, Francisco Joel; Parra‐Bracamonte, Gaspar Manuel; Sifuentes‐Rincón, Ana María; Martínez-González, Juan Carlos; Gondro, Cedric; García-Pérez, Carlos A.; López-Bustamante, L. A.

doi:10.2527/jas.2016-0359

Cited by 39 publications

(35 citation statements)

References 45 publications

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“…in cattle. For HG and HH, many studies focus on only one growth stage, such as post-weaning height[19], yearling height[20], and stature in adulthood[13,21]. However, to date, no GWAS has been performed to evaluate the genetic architecture of HG and HH through the whole growing period in cattle.…”

Section: Introductionmentioning

confidence: 99%

Genome-wide association studies identified multiple genetic loci for body size at four growth stages in Chinese Holstein cattle

Chu

Guo

et al. 2017

PLoS ONE

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The growth and maturity of cattle body size affect not only feed efficiency, but also productivity and longevity. Dissecting the genetic architecture of body size is critical for cattle breeding to improve both efficiency and productivity. The volume and weight of body size are indicated by several measurements. Among them, Heart Girth (HG) and Hip Height (HH) are the most important traits. They are widely used as predictors of body weight (BW). Few association studies have been conducted for HG and HH in cattle focusing on single growth stage. In this study, we extended the Genome-wide association studies to a full spectrum of four growth stages (6-, 12-, 18-, and 24-months after birth) in Chinese Holstein heifers. The whole genomic single nucleotide polymorphisms (SNPs) were obtained from the Illumina BovineSNP50 v2 BeadChip genotyped on 3,325 individuals. Estimated breeding values (EBVs) were derived for both HG and HH at the four different ages and analyzed separately for GWAS by using the Fixed and random model Circuitous Probability Unification (FarmCPU) method. In total, 27 SNPs were identified to be significantly associated with HG and HH at different growth stages. We found 66 candidate genes located nearby the associated SNPs, including nine genes that were known as highly related to development and skeletal and muscular growth. In addition, biological function analysis was performed by Ingenuity Pathway Analysis and an interaction network related to development was obtained, which contained 16 genes out of the 66 candidates. The set of putative genes provided valuable resources and can help elucidate the genomic architecture and mechanisms underlying growth traits in dairy cattle.

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Section: Introductionmentioning

confidence: 99%

Genome-wide association studies identified multiple genetic loci for body size at four growth stages in Chinese Holstein cattle

Chu

Guo

et al. 2017

PLoS ONE

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“…Many studies have reported QTLs and genes associated with growth traits in cattle (e.g., body weight and average daily gain) using the GWAS strategy [40,41]. However, few QTLs have consistently been identified as being associated with growth traits among breeds of cattle, including for Brangus heifers [42], Japanese Black (Wagyu) cattle [43], Charolais beef cattle [8], Siberia cattle [1], Nellore cattle [3], and the Chinese Simmental beef cattle examined in this study. These findings imply that further in-depth research is required to determine whether breed-specific QTLs exist.…”

Section: Potential Genomic Regions and Candidate Genes Reveal The Commentioning

confidence: 87%

“…Buzanskas et al [7] performed a GWAS in 404 Canchim beef cattle using BovineHD BeadChip and found four SNPs associated with birth weight. Jahuey-Martinez et al [8] found 18 SNPs located in 13 Bos taurus chromosomes (BTA) and highlighted five genes (TRAF6, CDH11, KLF7, MIR181A-1 and PRCP) that were associated with growth traits in a population of 855 Charolais beef cattle genotyped for 76,883 SNPs. Although some progress has been made, the genetic architecture of these economically important traits remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

“…Although some progress has been made, the genetic architecture of these economically important traits remains poorly understood. Furthermore, the majority of GWASs for growth traits in beef cattle have only used a small sample of genotyped animals and low-density SNP arrays, which has limited the statistical power of the association analysis [1,8]. To address this issue, the weighted single-step GWAS (wssGWAS) is preferable for association analysis in Chinese beef cattle, for which large numbers of individuals have phenotypes and pedigrees but fewer are genotyped.…”

Section: Introductionmentioning

confidence: 99%

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Weighted Single-Step Genome-Wide Association Study for Growth Traits in Chinese Simmental Beef Cattle

Zhuang

Yang

et al. 2020

Genes

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Improving the genetic process of growth traits is one of the major goals in the beef cattle industry, as it can increase meat production and reduce the cost of raising animals. Although several quantitative trait loci affecting growth traits in beef cattle have been identified, the genetic architecture of these economically important traits remains elusive. This study aims to map single nucleotide polymorphisms (SNPs) and genes associated with birth weight (BW), yearling weight (YW), average daily gain from birth to yearling (BYADG), and body weight at the age of 18 months (18MW) in a Chinese Simmental beef cattle population using a weighted, single-step, genome-wide association study (wssGWAS). Phenotypic and pedigree data from 6022 animals and genotypes from 744 animals (596,297 SNPs) were used for an association analysis. The results showed that 66 genomic windows explained 1.01-20.15% of the genetic variance for the four examined traits, together with the genes near the top SNP within each window. Furthermore, the identified genomic windows (>1%) explained 50.56%, 57.71%, 61.78%, and 37.82% of the genetic variances for BW, YW, BYADG, and 18MW, respectively. Genes with potential functions in muscle development and regulation of cell growth were highlighted as candidates for growth traits in Simmental cattle (SQOR and TBCB for BW, MYH10 for YW, RLF for BYADG, and ARHGAP31 for 18MW). Moreover, we found 40 SNPs that had not previously been identified as being associated with growth traits in cattle. These findings will further advance our understanding of the genetic basis for growth traits and will be useful for the molecular breeding of BW, YW, BYADG, and 18MW in the context of genomic selection in beef cattle.

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“…For beef cattle, birth weight is an important trait that represents the first phenotypic variable of a new individual in a population and is also considered an indicator of calving ease (Canellas et al, 2012). Furthermore, for beef cattle producers, calves with greater weights at weaning have the advantage of being more morphologically developed and better equipped to successfully cope with the environment (Jahuey-Martínez et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Influence of temperament-related genes on live weight traits of Charolais cows

Brenner¹,

Sifuentes‐Rincón²,

Rodríguez-Almeida³

et al. 2020

Revista Brasileira De Zootecnia

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R. Bras. Zootec., 49:e20180121, 2020 https://doi.org/10.37496/rbz4920180121Breeding and genetics Full-length research article Influence of temperament-related genes on live weight traits of Charolais cowsABSTRACT -We investigated whether a panel of molecular markers previously associated with temperament has an effect on live growth traits. Phenotypic data from 412 Charolais cows categorized according to their age in adult and young cows were used to determine Pearson's correlations between birth (BW), weaning (WW), and yearling live (YW) weight and temperament traits (measured as exit velocity [EV] and temperament score [TS]). For association analysis, selective genotyping of a group of 80 cows identified as the most docile and temperamental were genotyped with a 151-SNP (single-nucleotide polymorphisms) panel of molecular markers previously associated with temperament. Significant Pearson's correlations between birth weight and weaning weight and the two temperament measurements (EV and TS) were observed only in the young cow group. Significant effects of ten SNP on BW and WW were observed. Four markers located on candidate genes for temperament traits also had an effect on birth weight and weaning weight in Charolais cows, which indicates that both traits could be influenced by the same genes.How to cite: Garza-Brenner, E.; Sifuentes-Rincón, A. M.; Rodríguez-Almeida, F. A.; Randel, R. D.; Parra-Bracamonte, G. M. and Arellano-Vera, W. 2020. Influence of temperament-related genes on live weight traits of Charolais cows. Revista Brasileira de Zootecnia 49:e20180121.

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Genomewide association analysis of growth traits in Charolais beef cattle1

Cited by 39 publications

References 45 publications

Genome-wide association studies identified multiple genetic loci for body size at four growth stages in Chinese Holstein cattle

Genome-wide association studies identified multiple genetic loci for body size at four growth stages in Chinese Holstein cattle

Weighted Single-Step Genome-Wide Association Study for Growth Traits in Chinese Simmental Beef Cattle

Influence of temperament-related genes on live weight traits of Charolais cows

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