Genomic Abnormalities as Biomarkers and Therapeutic Targets in Acute Myeloid Leukemia

Ribeiro, Sara; Eiring, Anna M.; Khorashad, Jamshid S.

doi:10.3390/cancers13205055

Cited by 9 publications

(6 citation statements)

References 170 publications

(243 reference statements)

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“…The BCL-2 family proteins play marked role in the formation and treatment of leukemia. BCL-2 is essential to the survival of AML cells; hence, blocking BCL-2 activity causes these cells to die [234]. Overexpression of anti-apoptotic BCL-2 proteins, such as BCL-2, BCL-Xl, and mcl-1, is linked with a poor prognosis and resistance to treatment in patients with acute myeloid leukemia (AML).…”

Section: Leukemiamentioning

confidence: 99%

Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic context

Saddam,

Paul,

Habib

et al. 2024

Egypt J Med Hum Genet

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Apoptosis, also known as the programmed death of cells, is responsible for maintaining the homeostasis of tissues, and this function is carried out by caspases. The process of apoptosis is carried out via two distinct pathways: the extrinsic pathway, which is governed by death receptors, and the intrinsic pathway, also known as the mitochondrial pathway. The BCL-2 protein family encoded by the BCL-2 gene, located at the 18q21.33 chromosomal location, is in charge of regulating the intrinsic pathway, which is responsible for inducing cell death via the permeabilization of the mitochondrial membrane and the release of apoptosis-inducing components. The BCL-2 homology (BH1, BH2, BH3, BH4) domains of this family proteins are crucial for their functioning, and their common BH domains allow interactions between members of the same family and can also serve as indications of pro- or anti-apoptotic activity. A direct correlation may be shown between the overexpression of BCL-2 and the postponement of cell death. It has been determined that a change in the expression of BCL-2 is the root cause of a variety of malignancies, including lung, breast, melanoma, and chronic lymphocytic leukemia, multiple sclerosis, diabetes. In this review, we addressed the genetic information and structural homology of BCL-2 family members. Further, we elucidate the pro-apoptotic and anti-apoptotic roles of the family members. This review highlights the most recent developments in the BCL-2 protein family and presents evidence that targeting this family proteins may have a positive impact on the treatment of medical problems that are still underserved.

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Section: Leukemiamentioning

confidence: 99%

Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic context

Saddam,

Paul,

Habib

et al. 2024

Egypt J Med Hum Genet

View full text Add to dashboard Cite

show abstract

“…The BCL-2 family proteins play marked role in the formation and treatment of leukemia. BCL-2 is essential to the survival of AML cells; hence, blocking BCL-2 activity causes these cells to die [234]. Overexpression of antiapoptotic BCL-2 proteins, such as BCL-2, BCL-Xl, and mcl-1, is linked with a poor prognosis and resistance to treatment in patients with acute myeloid leukemia (AML).…”

Section: Leukemiamentioning

confidence: 99%

Emerging Biomarkers and Potential Therapeutics of the BCL-2 Protein Family: The Apoptotic and Anti-Apoptotic Context

Paul¹,

Saddam²,

Habib³

et al. 2023

Preprint

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Apoptosis, also known as the programmed death of cells, is responsible for maintaining the homeostasis of tissues and this function is carried out by caspases. The process of apoptosis is carried out via two distinct pathways: the extrinsic pathway, which is governed by death receptors, and the intrinsic pathway, also known as the mitochondrial pathway. The BCL-2 protein family encoded by the BCL-2 gene, located at the 18q21.33 chromosomal location, is in charge of regulating the intrinsic pathway, which is responsible for inducing cell death via the permeabilization of the mitochondrial membrane and the release of apoptosis - inducing components. The BCL-2 homology (BH1, BH2, BH3, BH4) domains of this family proteins are crucial for their functioning and their common BH domains allow interactions between members of the same family and can also serve as indications of pro- or anti-apoptotic activity. A direct correlation may be shown between the overexpression of BCL-2 and the postponement of cell death. It has been determined that a change in the expression of BCL-2 is the root cause of a variety of malignancies, including lung, breast, melanoma, and chronic lymphocytic leukemia, Multiple Sclerosis, Diabetes. In this review, we discuss the therapeutic potential of regulating BCL-2 family connections and their relevance to health and disease.

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“…CircRNAs have the potential to be diagostic and prognostic biomarkers, and therapeutic targets because that they are highly stable, cell- and tissue-specific expressed, and their expression levels often associated with clinical and pathological characteristics ( D'Ambra et al, 2019 ; Li et al, 2020b ; Wang Y. et al, 2020 ). Different molecular-based biomarkers such as cytogenetics, epigenetics, genetics, noncoding RNAs and protemocis have been well-documented in AML ( Trino et al, 2018 ; Thakral et al, 2020 ; Ribeiro et al, 2021 ; Kirtonia et al, 2022 ; Wiatrowski et al, 2022 ). CircRNAs act as tumor suppressors or oncogenes to involve in the development of various diseases such as AML and are becoming new diagnostic and prognostic biomarkers ( Zhou et al, 2020 ; Issah et al, 2021 ; Singh V. et al, 2021 ) ( Table 3 ).…”

Section: Clinical Significance Of Circrnas In Acute Myeloid Leukemiamentioning

confidence: 99%

Functions and clinical significance of circular RNAs in acute myeloid leukemia

et al. 2022

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Circular RNAs (circRNAs) are a class of covalently closed single-stranded RNA molecules. Four types of circRNAs have been reported in animal cells, and they have typical characteristics in their biogenesis, nuclear export and degradation. Advances in our understanding of the molecular functions of circRNAs in sponging microRNAs, modulating transcription, regulating RNA-binding proteins, as well as encoding proteins have been made very recently. Dysregulated circRNAs are associated with human diseases such as acute myeloid leukemia (AML). In this review, we focus on the recently described mechanisms, role and clinical significance of circRNAs in AML. Although great progress of circRNAs in AML has been achieved, substantial efforts are still required to explore whether circRNAs exert their biological function by other mechanisms such as regulation of gene transcription or serving as translation template in AML. It is also urgent that researchers study the machineries regulating circRNAs fate, the downstream effectors of circRNAs modulatory networks, and the clinical application of circRNAs in AML.

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Genomic Abnormalities as Biomarkers and Therapeutic Targets in Acute Myeloid Leukemia

Cited by 9 publications

References 170 publications

Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic context

Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic context

Emerging Biomarkers and Potential Therapeutics of the BCL-2 Protein Family: The Apoptotic and Anti-Apoptotic Context

Functions and clinical significance of circular RNAs in acute myeloid leukemia

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