2021
DOI: 10.1016/j.cbpc.2021.109095
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Genomic analysis of the carboxylesterase family in the salmon louse (Lepeophtheirus salmonis)

Abstract: The pyrethroid deltamethrin and the macrocyclic lactone emamectin benzoate (EMB) are used to treat infestations of farmed salmon by parasitic salmon lice, Lepeophtheirus salmonis . While the efficacy of both compounds against Atlantic populations of the parasite has decreased as a result of the evolution of resistance, the molecular mechanisms of drug resistance in L. salmonis are currently not fully understood. The functionally diverse carboxylesterases (CaE) fami… Show more

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“…However, while DTM resistance of L. salmonis field populations determined in acute bioassays was associated with genotypes at two mtDNA SNP loci, the SNP in LsNa v 1.3 showed no such association and did not explain mt-DNA independent DTM resistance observed in a crossing experiment 25 . Similarly, genome-wide characterisation and transcript expression studies of L. salmonis CYP and CaE genes failed to provide evidence for an upregulation of CYPs or CaEs in DTM resistant parasites 26 , 27 .…”
Section: Introductionmentioning
confidence: 99%
“…However, while DTM resistance of L. salmonis field populations determined in acute bioassays was associated with genotypes at two mtDNA SNP loci, the SNP in LsNa v 1.3 showed no such association and did not explain mt-DNA independent DTM resistance observed in a crossing experiment 25 . Similarly, genome-wide characterisation and transcript expression studies of L. salmonis CYP and CaE genes failed to provide evidence for an upregulation of CYPs or CaEs in DTM resistant parasites 26 , 27 .…”
Section: Introductionmentioning
confidence: 99%