Genomic characterization of peste des petits ruminants vaccine seed “45G37/35-k”, Russia

Kwiatek, Olivier; Libeau, Geneviève; Guendouz, Samia; Corbanini, Chloé; Gogin, Andrey; Lunitsin, A.V.; Sindryakova, Irina P.; Koblasov, Denis; Bataillé, Arnaud

doi:10.1186/s13567-022-01099-w

Cited by 3 publications

(6 citation statements)

References 13 publications

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“…The ARRIAH strain produced by FGBI ARRIAH belongs to lineage II, as the Nigeria 75-1 vaccine strain does, but is not directly related to the wild Nigeria strain at the origin of this vaccine [ 26 ]. Although it still lacks WOAH endorsement, this vaccine has been used in some central Asian countries to control PPRV spread [ 33 , 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…A recent study revealed that a PPRV vaccine strain, 45G37-k (Pokrov, Russia), differed from Nigeria75/1 by 248 nucleotides; however, the ARRIAH strain was related to 45G37-k, indicating the shared origin. These lineage II variants likely originated from a distinct lineage II field isolate that circulated alongside the predecessor of Nigeria 75/1 in the past [ 26 ]. Although Nigeria 75/1 was attenuated on 75 passages in Vero cells [ 20 ], the attenuating mutations accrued during this passage history differ from those of the ARRIAH and 45G37-k strains (35 passages in lamb kidney cells for ARRIAH and serial passages in lamb kidneys, lamb testes, and Saiga kidney cells for 45G37-k) [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…These lineage II variants likely originated from a distinct lineage II field isolate that circulated alongside the predecessor of Nigeria 75/1 in the past [ 26 ]. Although Nigeria 75/1 was attenuated on 75 passages in Vero cells [ 20 ], the attenuating mutations accrued during this passage history differ from those of the ARRIAH and 45G37-k strains (35 passages in lamb kidney cells for ARRIAH and serial passages in lamb kidneys, lamb testes, and Saiga kidney cells for 45G37-k) [ 26 ]. Unfortunately, the complete passage history or the exact date and place of collection of the field isolate is not available.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, we assessed the efficacy of the ARRIAH vaccine strain (designated as V1, FGBI ARRIAH, Vladimir, Russia), which was previously identified to be related to 45G37-k (Federal Research Center for Virology and Microbiology, Pokrov, Russia) and to share the same origin (lineage II) [ 26 ]. The efficacy of the ARRIAH vaccine strain was evaluated against two commercially available batches, each from a different manufacturer, containing the Nigeria75/1 vaccine strain.…”

Section: Methodsmentioning

confidence: 99%

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The Live Attenuated Vaccine Strain “ARRIAH” Completely Protects Goats from a Virulent Lineage IV Field Strain of Peste Des Petits Ruminants Virus

Byadovskaya,

Shalina,

Prutnikov

et al. 2024

Vaccines

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Peste des petits ruminants (PPR) is a transboundary viral disease that affects small ruminants, such as goats and sheep, in Africa, the Middle East, and Asia, causing substantial damage to livelihoods and disrupting livestock trade. Although Russia is PPR virus (PPRV)-free, controlling PPRV in neighboring countries is the top national priority. Recent PPR outbreaks in Mongolia and other countries in the Middle East caused by a lineage IV virus represent a risk of transboundary emergence in neighboring countries, including China, Kazakhstan, and Russia. In the present study, we assessed the potency and safety of the ARRIAH live attenuated PPRV vaccine (lineage II) in Zaannen and Nubian goat breeds by challenging them with a virulent lineage IV Mongolia/2021 isolate. For comparison, two commercial vaccines of Nigeria75/1 strain were used. The ARRIAH-vaccinated animals showed an increase in body temperature of 1–1.5 °C above the physiological norm, similar to the animals vaccinated with Nigeria75/1 vaccines. In all vaccinated groups, the average rectal temperature never exceeded 39.4–39.7 °C throughout the infection period, and no clinical signs of the disease were observed, demonstrating vaccine efficacy and safety in the current experimental setting. However, the control group (mock vaccinated) challenged with Mongolia/2021 PPRV exhibited moderate-to-severe clinical signs. Overall, the findings of the present study demonstrate that the ARRIAH vaccine strain has a promising protective phenotype compared with Nigeria75/1 vaccines, suggesting its potential as an effective alternative for curbing and controlling PPR in affected countries. Although the ARRIAH vaccine against PPR is not currently endorsed by the World Organization for Animal Health due to its incomplete safety and potency profile, this study is the first step to provide experimentally validated data on the ARRIAH vaccine.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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The Live Attenuated Vaccine Strain “ARRIAH” Completely Protects Goats from a Virulent Lineage IV Field Strain of Peste Des Petits Ruminants Virus

Byadovskaya,

Shalina,

Prutnikov

et al. 2024

Vaccines

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“…PPRV genome analyses have also been important in exploring the origin and the attenuation process of PPR vaccine strains ( Eloiflin et al. 2019 ; Kwiatek et al. 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Comparative evolutionary analyses of peste des petits ruminants virus genetic lineages

Courcelle,

Salami,

Tounkara

et al. 2024

Virus Evolution

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Peste des petits ruminants virus (PPRV) causes a highly infectious disease affecting mainly goats and sheep in large parts of Africa, Asia, and the Middle East and has an important impact on the global economy and food security. Full genome sequencing of PPRV strains has proved to be critical to increasing our understanding of PPR epidemiology and to inform the ongoing global efforts for its eradication. However, the number of full PPRV genomes published is still limited and with a heavy bias towards recent samples and genetic Lineage IV (LIV), which is only one of the four existing PPRV lineages. Here, we generated genome sequences for twenty-five recent (2010–6) and seven historical (1972–99) PPRV samples, focusing mainly on Lineage II (LII) in West Africa. This provided the first opportunity to compare the evolutionary pressures and history between the globally dominant PPRV genetic LIV and LII, which is endemic in West Africa. Phylogenomic analysis showed that the relationship between PPRV LII strains was complex and supported the extensive transboundary circulation of the virus within West Africa. In contrast, LIV sequences were clearly separated per region, with strains from West and Central Africa branched as a sister clade to all other LIV sequences, suggesting that this lineage also has an African origin. Estimates of the time to the most recent common ancestor place the divergence of modern LII and LIV strains in the 1960s–80s, suggesting that this period was particularly important for the diversification and spread of PPRV globally. Phylogenetic relationships among historical samples from LI, LII, and LIII and with more recent samples point towards a high genetic diversity for all these lineages in Africa until the 1970s–80s and possible bottleneck events shaping PPRV’s evolution during this period. Molecular evolution analyses show that strains belonging to LII and LIV have evolved under different selection pressures. Differences in codon usage and adaptative selection pressures were observed in all viral genes between the two lineages. Our results confirm that comparative genomic analyses can provide new insights into PPRV’s evolutionary history and molecular epidemiology. However, PPRV genome sequencing efforts must be ramped up to increase the resolution of such studies for their use in the development of efficient PPR control and surveillance strategies.

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Structure, Attachment and Transmembrane Internalisation of Peste Des Petits Ruminants Virus

Zou,

Niu,

Cheng

et al. 2024

Veterinary Medicine & Sci

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Peste des petits ruminants virus (PPRV), a single‐stranded negative‐sense RNA virus with an envelope, belongs to the Morbillivirus in the Paramyxoviridae family and is prevalent worldwide. PPRV infection causes fever, stomatitis, diarrhoea, pneumonia, abortion and other symptoms in small ruminants, with a high mortality rate that poses a significant threat to the sustainability and productivity of the small ruminant livestock sector. The PPRV virus particles have a diameter of approximately 400–500 nm and are composed of six structural proteins: nucleocapsid protein (N), phosphoprotein (P), envelope matrix protein (M), fusion protein (F), haemagglutinin protein (H) and large protein (L). Each protein has a distinct role in the virus's life cycle. Although the life cycle activities of PPRV have been widely reported, they are still limited. Research has demonstrated that PPRV has distinct adhesion factors on various cell surfaces, such as the epithelial cell adhesion factor nectin‐4 or the lymphocyte adhesion factor SLAM. After attaching to the cell, the F and H proteins on the PPRV membrane interact with each other, resulting in a conformational change in the F protein. This change allows the F protein to enter the cell through direct fusion with the host cell membrane. The virus enters the host cell via the outer vesicle endocytosis strategy and replicates and proliferates through the role of caveolin, actin, dynein and cholesterol on the host cell membrane. This review summarises the viral structure, attachment mechanism and transmembrane internalisation mechanism of PPRV. The aim of this review is to provide theoretical support for the development of PPRV inhibitors and the prevention and control of PPR.

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Genomic characterization of peste des petits ruminants vaccine seed “45G37/35-k”, Russia

Cited by 3 publications

References 13 publications

The Live Attenuated Vaccine Strain “ARRIAH” Completely Protects Goats from a Virulent Lineage IV Field Strain of Peste Des Petits Ruminants Virus

The Live Attenuated Vaccine Strain “ARRIAH” Completely Protects Goats from a Virulent Lineage IV Field Strain of Peste Des Petits Ruminants Virus

Comparative evolutionary analyses of peste des petits ruminants virus genetic lineages

Structure, Attachment and Transmembrane Internalisation of Peste Des Petits Ruminants Virus

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