Genomic epidemiological characteristics of dengue fever in Guangdong province, China from 2013 to 2017

Sun, Bo; Zhang, Xin; Zhang, Huan; Liu, Haizhou; Sun, Li; Tan, Qiqi; Liang, Mifang; Wu, De; Liu, Di

doi:10.1371/journal.pntd.0008049

Cited by 13 publications

(12 citation statements)

References 45 publications

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“…Meanwhile, DENV1-4 E gene sequences isolated in Guangzhou scattered in phylogenetic trees (Figs. 2 , 3 , 4 , 5 ), displayed no sign of succession, and showed close relationships with Southeast Asian strains; this was in line with the results of complete genome research in Guangdong 5 , supporting the idea that dengue in Guangzhou is more likely caused by imported cases rather than being endemic.…”

Section: Discussionsupporting

confidence: 77%

Epidemiological and genomic analysis of dengue cases in Guangzhou, China, from 2010 to 2019

Jiang

Liu

et al. 2023

Sci Rep

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With a long epidemic history and a large number of dengue cases, Guangzhou is a key city for controlling dengue in China. The demographic information regarding dengue cases, and the genomic characteristics of the envelope gene of dengue viruses, as well as the associations between these factors were investigated from 2010 to 2019, to improve the understanding of the epidemiology of dengue in Guangzhou. Demographic data on 44,385 dengue cases reported to the Notifiable Infectious Disease Report System were analyzed using IBM SPSS Statistics v. 20. Dengue virus isolates from patient sera were sequenced, and phylogenetic trees were constructed using PhyML 3.1. There was no statistical difference in the risk of dengue infection between males and females. Unlike other areas in which dengue is endemic, the infection risk in Guangzhou increased with age. Surveillance identified four serotypes responsible for dengue infections in Guangzhou. Serotype 1 remained prevalent for most of the study period, whereas serotypes 3 and 4 were prevalent in 2012 and 2010, respectively. Different serotypes underwent genotype and sublineage shifts. The epidemiological characteristics and phylogeny of dengue in Guangzhou suggested that although it has circulated in Guangzhou for decades, it has not been endemic in Guangzhou. Meanwhile, shifts in genotypes, rather than in serotypes, might have caused dengue epidemics in Guangzhou.

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Section: Discussionsupporting

confidence: 77%

Epidemiological and genomic analysis of dengue cases in Guangzhou, China, from 2010 to 2019

Jiang

Liu

et al. 2023

Sci Rep

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“…In recent years, the global incidence of dengue fever has been increasing, with approximately 390 million infections per year, including nearly 20,000 deaths ( Guzman et al, 2010 ; Guo et al, 2017 ). In 2013, the local outbreaks of dengue fever occurred in Guangdong and Yunnan provinces of China, resulting in thousands of infections ( Luo et al, 2017 ; Sun et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Metagenome Sequencing Reveals the Microbiome of Aedes albopictus and Its Possible Relationship With Dengue Virus Susceptibility

Zhao

Gao

et al. 2022

Front. Microbiol.

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Dengue fever virus (DENV) is a mosquito-borne flavivirus that poses a serious risk to human health. Aedes albopictus is a widely distributed vector of dengue fever in China. Based on the impact of physiological activity, the microbiome in A. albopictus will provide a novel environment-friendly approach to control DENV transmission. We performed metagenomic sequencing on A. albopictus before and after exposure to DENV blood meal to detect microbiome variation of A. albopictus with different susceptibilities to DENV. The dominant phyla in A. albopictus microbiome were Proteobacteria and Ascomycota, and the dominant genera were Aspergillus and Metarhizium. Gammaproteobacteria bacterium, Lactobacillus harbinensis, and Neurospora crassa differed significantly after DENV infection. There were 15 different microorganisms found to be involved in mosquito immunity and metabolism, such as Alphaproteobacteria bacterium, Methyloglobulus morosus, and Shigella sonnei, which might have an impact on the DENV susceptibility of A. albopictus. It was hypothesized that the lack of specific bacteria may lead to increased susceptibility of A. albopictus to DENV. Interventions in the microbiome composition or specific bacteria of A. albopictus may affect the susceptibility to DENV and control the mosquito-borne diseases efficiently.

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“…There are several reasons for the high proportion of SD in the study. Firstly, recent dengue virus serotype infection prevalent in Guangdong Province was easy to cause severe cases [14,15]. Secondly, our hospital is the designated unit for the management of SD.…”

Section: Discussionmentioning

confidence: 99%

The value of lung involvement in recognizing severe dengue-A retrospective study

Shi

et al. 2020

Preprint

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Background Dengue fever is a vector-borne disease transmitted by infected female Aedes mosquitoes. It has become the major threat to human beings especially in tropical and subtropical areas. It's important to find early parameters to identify severe dengue due to its poor prognosis. This study aimed to explore the value of lung involvement in identifying severe dengue (SD) from ordinary dengue.Methods 592 dengue patients admitted in the Third Affiliated Hospital of Sun Yat-sen University from July 2014 to January 2020 were enrolled. Patients were divided into two groups, dengue with lung involvement group (DWLI) and dengue without lung involvement group (DWOLI). According to the severity of dengue fever, patients in DWLI group were further divided into dengue subgroup and SD subgroup. The clinical characteristics, treatment and outcome of the patients were analyzed between groups and subgroups respectively.Results The rate of SD patients was higher in DWLI group than that in DWOLI group. The ratios of old age, smoking, hepatobiliary disease, hypertension, diabetes, coronary heart disease and cerebrovascular disease were higher in DWLI group than those in DWOLI group (all p<0.05). Other organs such as liver, kidney, digestive tract were affected more in DWLI group (all p<0.05). Respiratory symptoms such as cough and breathlessness were more common in DWLI group (both p<0.05). Subgroup analyses showed that SD subgroup patients had more respiratory symptoms as well (p<0.05). Inflammatory markers including C-reactive protein (CRP) and pro-calcitonin (PCT) were increased in DWLI group (both p<0.05). The ratios of pleural effusion and bilateral lung infiltration were correlated with SD (both p<0.05). The ratios of anti-virus，anti-bacteria and combined therapy were higher in DWLI group. There were 10 cases in DWLI group complicated with multiple organ dysfunction syndrome (MODS) while no MODS occurred in DWOLI group. Except for 2 patients with MODS died, all the other patients were cured.Conclusions Among dengue fever patients, the elderly, smoking population, those accompanied by underlying diseases were prone to have lung involvement. Dengue fever patients who develop clinical manifestations such as cough, breathlessness, pleural effusion and bilateral pneumonic exudation should be warned of SD.

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Genomic epidemiological characteristics of dengue fever in Guangdong province, China from 2013 to 2017

Cited by 13 publications

References 45 publications

Epidemiological and genomic analysis of dengue cases in Guangzhou, China, from 2010 to 2019

Epidemiological and genomic analysis of dengue cases in Guangzhou, China, from 2010 to 2019

Metagenome Sequencing Reveals the Microbiome of Aedes albopictus and Its Possible Relationship With Dengue Virus Susceptibility

The value of lung involvement in recognizing severe dengue-A retrospective study

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