Genomic Epidemiology of Corynebacterium diphtheriae in New Caledonia

Tessier, Eve; Hennart, Mélanie; Badell, Edgar; Passet, Virginie; Toubiana, Julie; Biron, Antoine; Gourinat, Ann-Claire; Merlet, A.; Colot, Julien; Brisse, Sylvain

doi:10.1128/spectrum.04616-22

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…Contributed to epidemiological studies of diphtheria in different regions of the world, from animal and human sources [85–88].…”

Section: Joint Research Projects and Phdsmentioning

confidence: 99%

Communicating and disseminating One Health: successes of the One Health European Joint Programme

Taylor,

Artursson,

Busani

et al. 2024

Journal of Medical Microbiology

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The application of a One Health approach recognizes that human health, animal health, plant health and ecosystem health are intrinsically connected. Tackling complex challenges associated with foodborne zoonoses, antimicrobial resistance, and emerging threats is imperative. Therefore, the One Health European Joint Programme was established within the European Union research programme Horizon 2020. The One Health European Joint Programme activities were based on the development and harmonization of a One Health science-based framework in the European Union (EU) and involved public health, animal health and food safety institutes from almost all EU Member States, the UK and Norway, thus strengthening the cooperation between public, medical and veterinary organizations in Europe. Activities including 24 joint research projects, 6 joint integrative projects and 17 PhD projects, and a multicountry simulation exercise facilitated harmonization of laboratory methods and surveillance, and improved tools for risk assessment. The provision of sustainable solutions is integral to a One Health approach. To ensure the legacy of the work of the One Health European Joint Programme, focus was on strategic communication and dissemination of the outputs and engagement of stakeholders at the national, European and international levels.

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“…Contributed to epidemiological studies of diphtheria in different regions of the world, from animal and human sources [85–88].…”

Section: Joint Research Projects and Phdsmentioning

confidence: 99%

Communicating and disseminating One Health: successes of the One Health European Joint Programme

Taylor,

Artursson,

Busani

et al. 2024

Journal of Medical Microbiology

View full text Add to dashboard Cite

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Decade of Carbapenemase-Producing Enterobacterales in New Caledonia: Integrative Surveillance Though Genomic, Phenotypic and Clinical approaches

Colot,

Bourles,

Cousin

et al. 2024

Preprint

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Carbapenemase-producing Enterobacterales (CPE) have been identified by the World Health Organization as global priority pathogens. The dissemination of these bacteria and outbreaks within healthcare facilities are of serious concern. This study investigated the transmission patterns and genetic characteristics of CPE isolated in New Caledonia from 2013 to 2022. The isolates were identified and characterized both phenotypically and whole-genome sequencing (WGS). In total 214 CPE were isolated: 199 non duplicate clinical isolates from 164 patients and 15 from hospital environmental surface. The most common genera in clinical samples were Enterobacter (34%) and Klebsiella (25%), with 194 isolates (98%) carrying IMP-type carbapenemase. WGS of 89 isolates revealed the dominance of the blaIMP-4 carbapenemase gene, found in 82 isolates. The blaIMP-4 was primarily predicted to be carried by IncL/M-type plasmid, found in 69% of the sequenced isolates. Our work revealed the circulation of 12 bacterial clusters with 61 strains involved in outbreaks or persistent over time. Genomic, phenotypic and clinical approaches identified 12 distinct outbreaks involving IMP producers. These results highlight the importance of studying plasmid transmission to better prevent silent spread of CPE. Ultimately, this study provides new guidelines for limiting the clinical spread of CPE in New Caledonia.

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Genomic Epidemiology of Corynebacterium diphtheriae in New Caledonia

Cited by 2 publications

References 40 publications

Communicating and disseminating One Health: successes of the One Health European Joint Programme

Communicating and disseminating One Health: successes of the One Health European Joint Programme

Decade of Carbapenemase-Producing Enterobacterales in New Caledonia: Integrative Surveillance Though Genomic, Phenotypic and Clinical approaches

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