Genomic erosion and horizontal gene transfer shape functional differences of the ExlA toxin in Pseudomonas spp.

Job, Viviana; Gómez-Valero, Laura; Renier, Adèle; Rusniok, Christophe; Bouillot, Stéphanie; Chenal-Francisque, Viviane; Gueguen, Erwan; Adrait, Annie; Robert-Genthon, Mylène; Jeannot, Katy; Panchev, Peter; Elsen, Sylvie; Fauvarque, Marie-Odile; Couté, Yohann; Buchrieser, Carmen; Attrée, Ina

doi:10.1016/j.isci.2022.104596

Cited by 5 publications

(2 citation statements)

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“…It was demonstrated that ErfA and Vfr bind to the exlBA promoter at two different locations, allowing independent binding of both regulators. However, while the activating signal of Vfr is known, the ex- system is also found in several other Pseudomonas species, including P. chlororaphis, P. protegens, P. putida, and P. entomophila, in which the toxin activity toward host cell membranes differs mainly due to differences in their C-terminal domains (Basso, Wallet, et al, 2017;Job et al, 2022). In-depth comparative genomic and phylogenetic analyses revealed the complex evolutionary history of the exlBA operon, which was acquired several times within the genus (Job et al, 2022).…”

Section: Signal Functionmentioning

confidence: 99%

“…Moreover, it was recently shown that as many as 13 response regulators were able to bind to the exlBA promoter in vitro (Trouillon et al, 2021), suggesting a much more complex regulatory mechanism for this TPS. The ExlAB secretion system is also found in several other Pseudomonas species, including P. chlororaphis , P. protegens , P. putida , and P. entomophila , in which the toxin activity toward host cell membranes differs mainly due to differences in their C‐terminal domains (Basso, Wallet, et al, 2017; Job et al, 2022). In‐depth comparative genomic and phylogenetic analyses revealed the complex evolutionary history of the exlBA operon, which was acquired several times within the genus (Job et al, 2022).…”

Section: The Regulation Of Cytolysinsmentioning

confidence: 99%

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The regulation of bacterial two‐partner secretion systems

Trouillon

Attrée

Elsen

2023

Molecular Microbiology

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Two‐partner secretion (TPS) systems, also known as Type Vb secretion systems, allow the translocation of effector proteins across the outer membrane of Gram‐negative bacteria. By secreting different classes of effectors, including cytolysins and adhesins, TPS systems play important roles in bacterial pathogenesis and host interactions. Here, we review the current knowledge on TPS systems regulation and highlight specific and common regulatory mechanisms across TPS functional classes. We discuss in detail the specific regulatory networks identified in various bacterial species and emphasize the importance of understanding the context‐dependent regulation of TPS systems. Several regulatory cues reflecting host environment during infection, such as temperature and iron availability, are common determinants of expression for TPS systems, even across relatively distant species. These common regulatory pathways often affect TPS systems across subfamilies with different effector functions, representing conserved global infection‐related regulatory mechanisms.

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Section: Signal Functionmentioning

confidence: 99%