Genomic glucocorticoid action in embryonic mouse neural stem cells

Nlrp6 protects from corticosterone-induced NSPC ferroptosis by modulating RIG-1/MAVS-mediated mitophagy

“…However, accumulating evidence points to a role for stress-induced mitochondrial dysfunction in the decrease of NSPC proliferative capacity, which leads to the decline of hippocampal neurogenesis and the development of cognitive deficits [ [9] , [10] , [11] ]. It is well elucidated prolonged stress or glucocorticoid has a negative impact on mitochondrial genome and function, ultimately contributing to cell senescence and death [ [12] , [13] , [14] ], but little is known about how this happens.…”