Genomic heterogeneity of hepatitis B virus (HBV) and outcome of perinatal HBV infection

Cacciola, Irene; Cerenzia, G; Pollicino, Teresa; Squadrito, Giovanni; Castellaneta, Stefania; Zanetti, Â.R.; Mieli‐Vergani, Giorgina; Raimondo, Giovanni

doi:10.1016/s0168-8278(01)00295-1

Cited by 47 publications

(43 citation statements)

References 37 publications

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“…outcome of the infection does not appear to be determined by variations in virulence of the viral strains (Thursz et al, 1995;Cacciola et al, 2002), but that host factors are likely to influence disease outcome (Lin et al, 1989;Chisari and Ferrari 1995). Thus, it is conceivable that genetic differences play an additional role.…”

Section: Association Of Common Promoter Polymorphisms Of Mcp1 With Hementioning

confidence: 99%

Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance

Park

Kim²,

Cheong³

et al. 2006

Exp Mol Med

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Hepatocellular carcinoma (HCC) is one of the most common malignant cancers closely associated with chronic infection by the hepatitis B virus (HBV) or the hepatitis C virus (HCV) throughout the world. In this study, the genetic associations of 20 known polymorphisms in eight candidate genes, including angiotensinogen (AGT), cadherin 1 (CDH1), cyclooxygenase 2 (COX2), monocyte chemotactic protein-1 (MCP1), multidrug resistance 1 (MDR1), chemokine ligand 5 (RANTES), thrombospondin 2 (THBS2), and thrombospondin 4 (THBS4), were analyzed in a large chronic hepatitis B cohort (n = 1,095) recruited from the Korean population. In addition, three polymorphisms in chemokine receptor 4 (CXCR4) and vimentin (VIM) identified in this study were also genotyped. Using logistic regression analysis controlling possible confounding factors, one common (freq.=0.367) promoter polymorphism of MCP1 (MCP1-2518G>A) among analyzed polymorphisms was significantly associated with clearance of HBV infection. The frequency of homozygotes for the MCP1-2518A allele (MCP1-2518A/A) among chronic hepatitis B virus (HBV) carrier patients was significantly higher than that among spontaneously recovered (SR) subjects (17.7% vs. 10.4%)(OR=1.78, P = 0.004). Our findings imply a plausible explanation for the contribution of host genetic determinants to the variable outcome of HBV infection, which might provide valuable information for future genetic study in this area.

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Section: Association Of Common Promoter Polymorphisms Of Mcp1 With Hementioning

confidence: 99%

Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance

Park

Kim²,

Cheong³

et al. 2006

Exp Mol Med

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“…The outcomes of HBV infection do not appear to be determined by the viral strains in themselves (Cacciola et al, 2002). However, the factors involved in the progression of chronic HBV infection to LC and to HCC among chronic HBV carriers require investigation.…”

Section: Introductionmentioning

confidence: 99%

Association between interleukin 6 promoter variants and chronic hepatitis B progression

Park

Lee²,

Kim³

et al. 2003

Exp Mol Med

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Interleukin 6 (IL6) plays an essential role in the regulation of immune response to chronic disease. In this study, the three known single nucleotide polymorphisms (SNPs) in the IL6 promoter region were genotyped in a large chronic hepatitis B cohort to evaluate the effects of IL6 promoter variants. The single base extension method was used for this genotyping. Haplotypes were constructed by the three SNPs in IL6. Allele frequencies were compared for; i) patients with chronic hepatitis (CH) and chronic carriers vs. chronic hepatis patients with clinical evidence of liver cirrhosis (LC) (i.e., portal hypertension), ii) cirrhotic patients with hepatocellular carcinoma (HCC) vs. without HCC by logistic regression, and iii) with respect to the time intervals from the onset of infection to HCC. Results were analyzed by Cox relative hazard analysis on the assumption that all the patients were infected during early infancy. The frequencies of each SNP were 0.002 (IL6-597 G A), 0.25 (IL6-572 C G) and 0.002 (IL6-174 G C), respectively, in the Korean population (n = 1,046). No significant associations were detected between IL6-572 C G and chronic hepatitis B outcome in this study; i.e., LC occurrence on CH (OR = 0.16-1.27, P = 0.13-0.71) and HCC occurrence on LC (OR = 1.04-1.23, P = 0.89-0.60) of heterozygotes and homozygotes for G allele in referent comparison to homozygotes for common allele (C/C genotype), and time interval to HCC (RH = 0.67-1.00; P = 0.14-0.99). In conclusion, there appeared to be no significant associations between IL6 promoter variants and disease outcome in chronic hepatitis B.

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“…[48][49][50] Based on some studies, genotype C might be a risk factor for HBV mother to child transmission. 51 It should be recommended that pregnant women who are HBeAg positive and have a high viral load be tested for HBV genotypes.…”

Section: Discussionmentioning

confidence: 99%

24 year outcomes of hepatitis B vaccination in Hangzhou, China

Xu²,

Wang³

et al. 2015

Human Vaccines & Immunotherapeutics

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To evaluate the impact of the universal infant HepB vaccination program on hepatitis B virus infection in Hangzhou, China. Hepatitis B incidences and HepB vaccination rates of Hangzhou from 1990 to 2003 were acquired from the historical paper-documents, while which were derived from China Information System for Diseases Control and , P < 0.001). Significant association was found between incidence of hepatitis B and HepB vaccination rate (r D 0 .946, x 2 D 11.813, P for trend D 0.001). A total of 5605 participants aged 0-59 y included in this serological survey. The prevalence of HBsAg, anti-HBs, anti-HBc, HBeAg and anti-HBe were 6.19%, 45.83%, 57.25%, 0.62%, and 4.37%, respectively. Hangzhou has successfully integrated the HepB into routine immunization programs and this has had a significant impact on decreasing the incidence of hepatitis B infection.

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Genomic heterogeneity of hepatitis B virus (HBV) and outcome of perinatal HBV infection

Cited by 47 publications

References 37 publications

Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance

Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance

Association between interleukin 6 promoter variants and chronic hepatitis B progression

24 year outcomes of hepatitis B vaccination in Hangzhou, China

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