1997
DOI: 10.1007/s007050050147
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Genomic heterogeneity of small ruminant lentiviruses: existenceof heterogeneous populations in sheep and of the samelentiviral genotypes in sheep and goats

Abstract: We have recently shown that French small ruminant lentiviruses (SRLV) from sheep are more similar to Caprine Arthritis Encephalitis Virus (CAEV) than to visna maedi virus (VMV) in a conserved region of the pol gene. To extend these results, we have examined sequences from a variable region of the env gene in French SRLV. We found that they were nearly equally distant from both CAEV and VMV strains, suggesting a considerable divergence since the initial introduction of the virus. Analysis of separate clones fro… Show more

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Cited by 90 publications
(69 citation statements)
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“…We demonstrate a much closer genetic relationship among these epidemiologically linked sequences, which differ by less than 1% from each other, than that found among viruses from epidemiologically unlinked animals, which differ by 4 to 8%, as is evident from Fig. 3 and has been reported previously (12,26,32). We thus present the first direct evidence that the recently identified SRLV subtype A4 is transmitted across the species barrier in both directions by the natural horizontal infection of adult animals.…”
Section: Discussionsupporting
confidence: 81%
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“…We demonstrate a much closer genetic relationship among these epidemiologically linked sequences, which differ by less than 1% from each other, than that found among viruses from epidemiologically unlinked animals, which differ by 4 to 8%, as is evident from Fig. 3 and has been reported previously (12,26,32). We thus present the first direct evidence that the recently identified SRLV subtype A4 is transmitted across the species barrier in both directions by the natural horizontal infection of adult animals.…”
Section: Discussionsupporting
confidence: 81%
“…Although some subtypes of the large and diverse SRLV group are found among both goats and sheep, thus presenting evidence for more than one event of interspecies transmission in the past (12,26,32), and although interspecies transmission has been achieved experimentally (1), the natural transmission of these viruses across the species barrier has never been documented directly. Here we have phylogenetically analyzed viruses isolated from goats or sheep that seroconverted after they were newly exposed to SRLV-infected animals of the other species.…”
Section: Discussionmentioning
confidence: 99%
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