Genomic heterogeneity within B/T mixed phenotype acute leukemia in a context of an immunophenotype

Zheng, Ruifang; Fuda, Franklin; Gagan, Jeffrey R.; Weinberg, Olga K.; Koduru, Prasad; Cantu, Miguel; Ludwig, Kathleen; Truscott, Jamie M.; Collins, Robert; Chung, Stephen; Madanat, Yazan F.; Chen, Weina

doi:10.1016/j.lrr.2023.100410

Leukemia Research Reports

2024

DOI: 10.1016/j.lrr.2023.100410

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Genomic heterogeneity within B/T mixed phenotype acute leukemia in a context of an immunophenotype

Ruifang Zheng,

Franklin Fuda,

Jeffrey R. Gagan

et al.

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2024

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Cited by 1 publication

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RUNX1::CBFA2T2 rearranged acute myeloid leukemia transformed from JAK2 V617F mutated primary myelofibrosis

Han,

Koduru,

Cantu

et al. 2024

eJHaem

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Acute myeloid leukemia (AML) with RUNX1::CBFA2T2 fusion is rare with largely unknown clinicopathological features and genomic characterization. We present one such case of AML transformed from JAK2 V617F mutated primary myelofibrosis and review the literature on this topic. The immunophenotype and the landscape of cooperative gene alterations in AML with RUNX1::CBFA2T2 resemble those of AML with RUNX1::RUNX1T1, including expression of CD19, cooperative gene alterations in signaling pathway (JAK2), epigenetic/chromatin and cell cycle regulation (TET2, SMC3, and CDKN2A/B), and additional chromosomal abnormalities (trisomies 8 and 15). This case study provides insights into the pathogenesis of this rare subtype of AML.

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RUNX1::CBFA2T2 rearranged acute myeloid leukemia transformed from JAK2 V617F mutated primary myelofibrosis

Han,

Koduru,

Cantu

et al. 2024

eJHaem

View full text Add to dashboard Cite

show abstract

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Genomic heterogeneity within B/T mixed phenotype acute leukemia in a context of an immunophenotype

Cited by 1 publication

References 30 publications

RUNX1::CBFA2T2 rearranged acute myeloid leukemia transformed from JAK2 V617F mutated primary myelofibrosis

RUNX1::CBFA2T2 rearranged acute myeloid leukemia transformed from JAK2 V617F mutated primary myelofibrosis

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