Genomic identification in the historical case of the Nicholas II royal family

Rogaev, Evgeny I.; Grigorenko, Anastasia P.; Moliaka, Yuri K.; Фасхутдинова, Г.; Goltsov, Alexei A.; Lahti, Arlene; Hildebrandt, Curtis J. B.; Kittler, Ellen L. W.; Морозова, Ирина

doi:10.1073/pnas.0811190106

Cited by 56 publications

(49 citation statements)

References 17 publications

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“…The usefulness of genetic genealogy and the many examples of successful retracements of famous family histories thanks to genetics as those of the third US president Thomas Jefferson (Foster et al, 1998;King et al, 2007a); Louis XVII and Marie-Antoinette of France (Jehaes et al, 1998;Jehaes et al, 2001), and the Romanov family (Gill et al, 1994;Rogaev et al, 2009) resulted in an enormous success of genetic genealogical research which is still growing exponentially. Moreover, (commercial) DNA tests have become commonly accessible and many genealogical associations organize genetic projects to accommodate the needs of their members.…”

Section: Recreational Genetic Genealogy As a Scientific Data Sourcementioning

confidence: 97%

“…Such sampling strategy is certainly not suited to survey population genetic structure on a small geographical scale because this approach cannot account for migrations in the recent past, which occur at a high frequency in a globalized world (Rogaev et al, 2009). Therefore, additional criteria are required in regional population studies to select DNA donors which are more associated to the particular region of interest.…”

mentioning

confidence: 99%

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Genetic genealogy comes of age: Perspectives on the use of deep‐rooted pedigrees in human population genetics

Larmuseau

Geystelen

Oven

et al. 2013

American J Phys Anthropol

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In this article, we promote the implementation of extensive genealogical data in population genetic studies. Genealogical records can provide valuable information on the origin of DNA donors in a population genetic study, going beyond the commonly collected data such as residence, birthplace, language, and self-reported ethnicity. Recent studies demonstrated that extended genealogical data added to surname analysis can be crucial to detect signals of (past) population stratification and to interpret the population structure in a more objective manner. Moreover, when in-depth pedigree data are combined with haploid markers, it is even possible to disentangle signals of temporal differentiation within a population genetic structure during the last centuries. Obtaining genealogical data for all DNA donors in a population genetic study is a labor-intensive task but the vastly growing (genetic) genealogical databases, due to the broad interest of the public, are making this job more time-efficient if there is a guarantee for sufficient data quality. At the end, we discuss the advantages and pitfalls of using genealogy within sampling campaigns and we provide guidelines for future population genetic studies.

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Section: Recreational Genetic Genealogy As a Scientific Data Sourcementioning

confidence: 97%

mentioning

confidence: 99%

Genetic genealogy comes of age: Perspectives on the use of deep‐rooted pedigrees in human population genetics

Larmuseau

Geystelen

Oven

et al. 2013

American J Phys Anthropol

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show abstract

“…The results of mtDNA, nucleic DNA and Y chromosome markers taken from minimal amounts of bone fragments carried out by a large research group under the direction of Professor Evgeny Rogaev in independent laboratories specialized in the study of old DNA (Russian Academy of Sciences, University of Massachusetts, Armed Forces DNA Identification Laboratory, Gregor Mendel Institute in Austria), allowing Edouard Rossel, governor of the Sverdlovsk region, to proclaim, on 30 April 2008, ‘The United States’ largest genetic laboratory has confirmed the identity of the remains recovered in August 2007; they are indeed the bodies of the children of Alexandra and Czar Nicolas II, more precisely the Grand Duchess Maria and the Czarevitch Alexis […] We have now recovered the entire family’ [3,4].…”

Section: The Discovery Of a Second Tomb In 2007mentioning

confidence: 99%

The ‘royal disease’– haemophilia A or B? A haematological mystery is finally solved

Lannoy¹,

Hermans

2010

Haemophilia

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'History can change blood. And blood can change the course of history'. Haemophilia is an illustration of this, as this congenital hereditary coagulation disorder, passed through the majority of royal European families at the beginning of the 20th century by Queen Victoria of England and Empress of the Indies, had indisputable political consequences, which led to one of the most defining moments of contemporary history: the Bolshevik Revolution. Today, none of Queen Victoria's living descendents carry haemophilia. Because of this, the characterization of haemophilia (deficit of either factor VIII or XI) and the identification of the causal mutation are rendered impossible. In 1991, a tomb containing the remains of Czar Nicolas II's entire family was discovered. A second tomb was discovered in 2007, allowing Russian and American scientists to fill in this gap in medical history. Following a scientific approach combining current genetic experimentation tools and the development of biological information technology, researchers were able to identify each body, allowing them to obtain precious genetic material from the young Czar Alexis, who was stricken by the disease, which revealed a causal substitution in the splice acceptor site of exon 4 in the F9 gene. This mutation that is responsible for haemophilia B had traumatized European royal families throughout the 20th century!

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“…Les résultats viennent d'être publiés récemment et confirment définitivement que les ossements retrouvés dans les deux fosses appartiennent bien aux sept membres de la famille impériale [3].…”

Section: éPilogueunclassified

Le massacre des Romanov : épilogue génomique

Gilgenkrantz¹

2009

Med Sci (Paris)

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Genomic identification in the historical case of the Nicholas II royal family

Cited by 56 publications

References 17 publications

Genetic genealogy comes of age: Perspectives on the use of deep‐rooted pedigrees in human population genetics

Genetic genealogy comes of age: Perspectives on the use of deep‐rooted pedigrees in human population genetics

The ‘royal disease’– haemophilia A or B? A haematological mystery is finally solved

Le massacre des Romanov : épilogue génomique

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