Genomic impact of cigarette smoke, with application to three smoking-related diseases

Talikka, Marja; Sierro, Nicolas; Ivanov, Nikolai V.; Chaudhary, Nveed; Peck, Michael J.; Hoeng, Julia; Coggins, Christopher R. E.; Peitsch, Manuel C.

doi:10.3109/10408444.2012.725244

Cited by 66 publications

(51 citation statements)

References 125 publications

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“…Tobacco is not only associated with malignancies, but also with serious non-cancerous illnesses which are life-threatening and life-limiting in their own rights. The causal and contributory association of tobacco towards serious conditions such as coronary heart disease, atherosclerosis, peripheral vascular diseases, chronic bronchitis, emphysema, etc is established beyond doubt (Apslund, 2003;Henley et al, 2004;Sharma et al, 2011;Talikka et al, 2012;Al-Attas et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Knowledge and Perceptions with Regards to Pictorial Health Warnings on Tobacco Products among Tobacco Users Diagnosed with Head and Neck Carcinoma: a Study from the Kumaon Hills of India

Pant¹,

Pandey²,

Madabhavi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Tobacco products continue to be used in large quantities in India despite the mandatory inclusion of pictorial health warnings (PHWs) on all tobacco packaging. The circumstances as to how people could continue the use of tobacco to the point of developing head and neck cancer despite enhanced awareness about the ill effects of tobacco is the main focus of this study. Materials and Methods: This study concerned patients with least 5-years history of tobacco use, having been diagnosed with histopathologically proven malignancies of the hypopharynx, larynx, oropharynx and oral cavity presenting at the Government Medical College-Haldwani, Nainital, India. A total of 183 patients were eligible for inclusion during July 1 2013-June 30 2014. Of these, 59 patients used smoked tobacco exclusively, 22 patients used smokeless tobacco exclusively, and 102 patients used both forms of tobacco. Among users of smoked forms, 75.2% (n=121) were beedi users, and 24.8% (n=40) were cigarette users. Patients were asked direct questions as to whether they had noticed the presence of PHWs upon tobacco products. The reasons as to why PHWs were not effective in stopping the patients from tobacco use were investigated. Results: Of the 183 patients, 146 reported being aware about the presence of PHWs, and when they were asked reasons as to why they continued tobacco despite being aware of ill-effects, the commonest reason chosen (by 53.4%) was that patients had not regarded themselves as using tobacco heavy enough to cause cancer. Among the 36 patients who reported as being oblivious to the presence of PHWs on tobacco products, 63.9% reported that the products they used never displayed any PHWs, and 36.1% reported never having paid attention to the packaging. The awareness about PHWs was higher among cigarette smokers in comparison to beedi smokers (100% vs 76.1%, p=0.0002). Conclusions: Locally produced and marketed tobacco products such as beedis and oral tobacco often fail to display PHWs. The presence of PHWs without doubt enhances awareness about the carcinogenic risks of tobacco. However, enhanced awareness alone may not be enough, and as elucidated by this study, some persons continue to use tobacco to the point of developing malignancies. The need of the hour is the implementation of legal and economic sanctions discouraging the use of tobacco products.Keywords: Pictorial health warnings -health warning labels -smoking health warning -head and neck cancer

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Knowledge and Perceptions with Regards to Pictorial Health Warnings on Tobacco Products among Tobacco Users Diagnosed with Head and Neck Carcinoma: a Study from the Kumaon Hills of India

Pant¹,

Pandey²,

Madabhavi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…It has been detected that smokers display increased levels of promoter hypermethylation, and higher levels of DNA methyltransferase 1, resulting in decreased expression of several genes, mainly associated with the cell cycle [32]. Histone H4 acetylation, in parallel with reduced function of histone deacetylase-2, is also induced by smoking [33][34][35].…”

Section: Smoking-related Epigenetic Alterationsmentioning

confidence: 99%

Smoking and interstitial lung diseases

et al. 2015

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For many years has been well known that smoking could cause lung damage. Chronic obstructive pulmonary disease and lung cancer have been the two most common smoking-related lung diseases. In the recent years, attention has also focused on the role of smoking in the development of interstitial lung diseases (ILDs). Indeed, there are three diseases, namely respiratory bronchiolitisassociated ILD, desquamative interstitial pneumonia and pulmonary Langerhans cell histiocytosis, that are currently considered aetiologically linked to smoking and a few others which are more likely to develop in smokers. Here, we aim to focus on the most recent findings regarding the role of smoking in the pathogenesis and clinical behaviour of ILDs. @ERSpublications Smoking is implicated in the pathogenesis and clinical behaviour of interstitial lung disease

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“…46 This could be used (or abused) in the contentious area of tobacco product harm reduction, for example, by designing and promoting "healthier" tobacco products that do not affect F2RL3 methylation (but possibly maintain carcinogenic and other pathogenic potential). More or less on the other end of the spectrum of possible applications, information on tobaccosmoking-associated long-lasting modifications of the genetic material could be evaluated in the context of motivational interventions for smoking cessation.…”

Section: Challenges and Potentials Of Epigenetics Of Smoking-related mentioning

confidence: 99%

Current Genetics and Epigenetics of Smoking/Tobacco-Related Cardiovascular Disease

Breitling¹

2013

ATVB

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Abstract-Genetic and epigenetic factors are of great importance in cardiovascular biology and disease. Tobacco-smoking, one of the most important cardiovascular risk factors, is itself partially determined by genetic background and is associated with altered epigenetic patterns. This could render the genetics and epigenetics of smoking-related cardiovascular disease a textbook example of environmental epigenetics and modern approaches to multimodal data analysis. A pronounced association of smoking-related methylation patterns in the F2RL3 gene with prognosis in patients with stable coronary heart disease has recently been described. Nonetheless, surprisingly little concrete knowledge on the role of specific genetic variants and epigenetic modifications in the development of cardiovascular diseases in people who smoke has been accumulated. Beyond the current knowledge, the present review briefly outlines some chief challenges and priorities for moving forward in this field. variation in antioxidative resilience seems to have no clinical cardiovascular consequences by itself, but-in interaction with the excessive oxidative stress caused by smoking-it means that smoking-associated cardiovascular risks are much greater in ε4 carriers than in other subjects. 10 It has been realized that such gene-environment interactions could also interfere with the performance of lipid-lowering drugs, but the extent of this potentially far-reaching problem still needs to be clarified. 11Given the multitude of physiological phenomena involved in tobacco-smoking-related cardiovascular disease (ref. 12 for an informative overview), it is hardly surprising that similar interactions with smoking have been reported for sequence variants in candidate genes coding for proteins as diverse as lipoprotein lipase and interleukin-6, 10 prothrombotic mutations like factor II G20210A, 13 or transforming growth factor-β1.14 One study investigating an interaction of interleukin-18 polymorphisms with smoking regarding cardiovascular disease risk was exceptional for its laudable collaborative design emphasizing statistical power.15 Nonetheless, the level of evidence for the vast majority of currently suggested gene-smoking interactions ultimately remains very limited. The evolution of findings concerning an interaction between tobacco-smoking and variants in glutathione S-transferase genes with respect to cardiovascular disease risk-which started out as a seemingly plausible effect modification supported by multiple lines of evidence 8 and was further sugested later meta-analysis, 16 only to vanish with subsequent sample size escalation 17 -should be taken as a reminder of the danger of prematurely overinterpreting gene-smoking interactions or even higher order interactions (eg, gene-age-smoking). 18Thorough replication and follow-up studies need to become more of a norm in this statistically challenging field. A New Era of EpigeneticsStudies on epigenetic aspects of health and disease have exploded in recent years, mainly because of technological a...

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Genomic impact of cigarette smoke, with application to three smoking-related diseases

Cited by 66 publications

References 125 publications

Evaluation of the Knowledge and Perceptions with Regards to Pictorial Health Warnings on Tobacco Products among Tobacco Users Diagnosed with Head and Neck Carcinoma: a Study from the Kumaon Hills of India

Evaluation of the Knowledge and Perceptions with Regards to Pictorial Health Warnings on Tobacco Products among Tobacco Users Diagnosed with Head and Neck Carcinoma: a Study from the Kumaon Hills of India

Smoking and interstitial lung diseases

Current Genetics and Epigenetics of Smoking/Tobacco-Related Cardiovascular Disease

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