Genomic Influence in the Prevention of Cardiovascular Diseases with a Sterol-Based Treatment

Martín, Ismael San Mauro; Olivares, Javier Andrés Blumenfeld; Arruche, Eva Pérez; Delgado, Esperanza Arce; Cabañas, María José Ciudad; Vilar, Elena Garicano; Yurrita, Luis Rodolfo Collado

doi:10.3390/diseases6020024

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…is discrepancy could be explained by the differences between ethnic populations that can contribute to the variation of prevalence rates of CAD. Furthermore, new studies are continuously being performed to identify whether APOA5 polymorphisms are associated with cardiovascular diseases occurrence [20][21][22][23]. In addition, accumulated data make it possible to conduct cumulative meta-analysis and assess the effects of APOA5 polymorphisms.…”

Section: Introductionmentioning

confidence: 99%

Association of c.56C > G (rs3135506) Apolipoprotein A5 Gene Polymorphism with Coronary Artery Disease in Moroccan Subjects: A Case-Control Study and an Updated Meta-Analysis

Morjane

Charoute

Ouatou

et al. 2020

Cardiology Research and Practice

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Purpose. Coronary artery diseases (CAD) are clinical cardiovascular events associated with dyslipidemia in common. The interaction between environmental and genetic factors can be responsible for CAD. The present paper aimed to examine the association between c.56C > G (rs3135506) APOA5 gene polymorphism and CAD in Moroccan individuals and to perform an association update meta-analysis. Materials and Methods. The c.56C > G variant was genotyped in 122 patients with CAD and 134 unrelated controls. Genetic association analysis and comparison of biochemical parameters were performed using R statistical language. In addition, a comprehensive meta-analysis including eleven published studies in addition to our case-control study results was conducted using Review Manager 5.3. Publication bias was examined by Egger’s test and funnel plot. Results. The case-control study data showed that the c.56C > G polymorphism was associated with CAD susceptibility under codominant (P-value = 0.001), recessive (P-value <0.001) and log-additive (P-value = 0.008) inheritance models. In addition, this polymorphism was significantly associated with increased levels of systolic and diastolic blood pressures, triglycerides, glycemia, and total cholesterol. Furthermore, meta-analysis showed a significant association between the c.56C > G gene polymorphism and increased risk of CAD under recessive (OR = 3.39[1.77–6.50], P value <0.001) and homozygote codominant (OR = 3.96[2.44–6.45], P value <0.001) models. Conclusion. Our case-control study revealed a significant association between c.56C > G polymorphism and CAD in the Moroccan population. In addition, meta-analysis data supported the implication of this polymorphism in CAD susceptibility.

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Section: Introductionmentioning

confidence: 99%

Association of c.56C > G (rs3135506) Apolipoprotein A5 Gene Polymorphism with Coronary Artery Disease in Moroccan Subjects: A Case-Control Study and an Updated Meta-Analysis

Morjane

Charoute

Ouatou

et al. 2020

Cardiology Research and Practice

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“…[212223] Daily consumption of phytosterol-enriched foods is widely used as a therapeutic option to improve lipid levels in plasma. [24] This has already been observed in studies that studied other lipids, such as LDL-c.[25]…”

Section: Introductionmentioning

confidence: 59%

Modulation of plasma triglycerides concentration by sterol-based treatment in children carrying different genes

Martín¹,

Rojo²,

Vilar³

et al. 2019

Ann Pediatr Card

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Background: Dyslipidemias have increased during the last decades in children. Aim: The objective of this study was to analyze the influence of different polymorphisms in plasma triglyceride levels of children following a dietary treatment with plant sterols. Design: A randomized, double-blind, crossover, controlled clinical trial was carried out in 26 children (16 women). Materials and Methods: Commercial milk, with 2.24 g sterols, was ingested daily during 3 weeks , and the same amount of kimmed milk without sterols, during the 3 week placebo phase. Both phases were separated by a washout period of 2 weeks. At the beginning and end of each phase, blood draws were performed. Results: Apolipoprotein A5 Ser19Trp ( P = 0.002), peroxisome proliferator-activated receptor-alpha L162V ( P = 0.003), APOE APOE2/3/4 ( P = 0.012), and APOE APOE2,3,4 ( P = 0.025) show statistically significant differences between their haplotypes in plasma triglyceride levels. Other genes did not show statistically significant differences. Conclusions: Further studies are needed to establish which genotype combinations would be the most protective against hypertriglyceridemia.

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Transmembrane transport of multicomponent liposome-nanoparticles into giant vesicles

Wang¹,

Li²,

Sun³

et al. 2022

Chinese Phys. B

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With the emergence and rapid development of nanotechnology, the nanoparticles hybridized with multicomponent lipids are more and more used in gene delivery. These vectors interact with the cell membrane before entering into the cell. Therefore, the nature of this interaction is important in investigating multicomponent liposome-nanoparticle (MLP) transport across the cell membrane. In this paper the transport of MLPs across the membranes of giant vesicles (GVs) in solvents is studied by using the self-consistent field theory (SCFT). Based on the analysis of the MLP permeating the GV membranes, a simple transport model is proposed. The effects of the difference in membrane morphology and the size of the nanoparticle on the endocytosis are discussed systematically. The role of energy barriers in quasi-equilibrium is also examined. The results indicate that the interaction between MLP and GV is a spontaneous process and the energy barrier needs overcoming to form metastable intermediates. The results provide theoretical reference for better understanding the transmembrane transport process of nanoparticles, and guidance for relevant experimental studies as well.

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Genomic Influence in the Prevention of Cardiovascular Diseases with a Sterol-Based Treatment

Cited by 4 publications

References 38 publications

Association of c.56C > G (rs3135506) Apolipoprotein A5 Gene Polymorphism with Coronary Artery Disease in Moroccan Subjects: A Case-Control Study and an Updated Meta-Analysis

Association of c.56C > G (rs3135506) Apolipoprotein A5 Gene Polymorphism with Coronary Artery Disease in Moroccan Subjects: A Case-Control Study and an Updated Meta-Analysis

Modulation of plasma triglycerides concentration by sterol-based treatment in children carrying different genes

Transmembrane transport of multicomponent liposome-nanoparticles into giant vesicles

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