Genomic insights into the genetic structure and population history of Mongolians in Liaoning Province

Hou, Xin; Zhang, Xianpeng; Li, Xin; Huang, Ting; Li, Wenhui; Zhang, Hailong; Huang, He; Yue, Wen

doi:10.3389/fgene.2022.947758

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…In addition, we merged these two datasets with our previous Liaoning Manchu and Mongolian datasets (Zhang X. et al, 2021;Hou et al, 2022). Finally, we obtained the "Merged-HO" dataset containing 41,585 SNPs and the "Merged-1240K" dataset containing 113,144 SNPs to perform the population genetic analysis.…”

Section: Data Mergingmentioning

confidence: 99%

Genetic structure and demographic history of Northern Han people in Liaoning Province inferred from genome-wide array data

Zhou¹,

Zhang²,

Li³

et al. 2022

Front. Ecol. Evol.

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In this study, we used typical and advanced population genetic analysis methods [principal component analysis (PCA), ADMIXTURE, FST, f3-statistics, f4-statistics, qpAdm/qpWave, qpGraph, ALDER (Admixture-induced Linkage Disequilibrium for Evolutionary Relationships) and TreeMix] to explore the genetic structure of 80 Han individuals from four different cities in Liaoning Province and reconstruct their demographic history based on the newly generated genome-wide data. We found that Liaoning Han people have genetic similarities with other northern Han people (Shandong, Henan, and Shanxi) and Liaoning Manchu people. Millet farmers in the Yellow River Basin (YRB) and the West Liao River Basin (WLRB) (57–98%) and hunter-gatherers in the Mongolian Plateau (MP) and the Amur River Basin (ARB) (40–43%) are the main ancestral sources of the Liaoning Han people. Our study further supports the “northern origin hypothesis”; YRB-related ancestry accounts for 83–98% of the genetic makeup of the Liaoning Han population. There are clear genetic influences of northern East Asian populations in the Liaoning Han people, ancient Northeast Asian-related ancestry is another dominant ancestral component, and large-scale population admixture has happened between Tungusic Manchu people and Han people. There are genetic differences among the Liaoning Han people, and we found that these differences are associated with different migration routes of Hans during the “Chuang Guandong” period in historical records.

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Section: Data Mergingmentioning

confidence: 99%

Genetic structure and demographic history of Northern Han people in Liaoning Province inferred from genome-wide array data

Zhou¹,

Zhang²,

Li³

et al. 2022

Front. Ecol. Evol.

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Population genomics advances in frontier ethnic minorities in China

Chen,

2024

Sci. China Life Sci.

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Dissecting the genetic admixture and forensic signatures of ethnolinguistically diverse Chinese populations via a 114-plex NGS InDel panel

Yang,

Liu,

Lun

et al. 2024

BMC Genomics

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Comprehensive characterizations of genetic diversity and demographic models of ethnolinguistically diverse Chinese populations are essential for elucidating their forensic characteristics and evolutionary past. We developed a 114-plex NGS InDel panel to genotype 114 genome-wide markers and investigated the genetic structures of Zhuang, Hui, Miao, Li, Tibetan, Yi, and Mongolian populations, encompassing five language families. This panel demonstrated robust performance, with exceptional potential for forensic individual identification and paternity testing, evidenced by the combined power of discrimination for 77 autosomal InDels (ranged from 1-3.6400 × 10 –30 to 1-3.5713 × 10 –32 ) and the combined power of exclusion (ranged from 1-2.1863 × 10 –6 to 1-2.1261 × 10 –7 ). The cumulative mean exclusion chance for 32 X-chromosomal InDels varied between 0.99996 and 0.99999 for trios and 0.99760 to 0.99898 for duos. We also analyzed genetic similarities and differences between these populations and 27 global populations, revealing distinct clusters among African, South Asian, East Asian, and European groups, with a close genetic affinity to East Asians. Notably, we identified geography-related genetic substructures: Inner Mongolia Mongolians and Gansu Huis formed a northern branch, Tibetans and Yis from Sichuan constituted a highland branch, and Guangxi Zhuangs exhibited close ties with Hainan Lis and Guangxi Miaos in the southern branch. Additionally, many InDels proved to be ancestry-informative markers for biogeographic ancestry inference. Collectively, these findings underscore the utility of the 114-plex NGS InDel panel as a complementary tool for forensic investigations and as a source of insights into the genetic architecture of ethnolinguistically distinct Chinese populations. Supplementary Information The online version contains supplementary material available at 10.1186/s12864-024-10894-y.

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Genomic insights into the genetic structure and population history of Mongolians in Liaoning Province

Cited by 3 publications

References 39 publications

Genetic structure and demographic history of Northern Han people in Liaoning Province inferred from genome-wide array data

Genetic structure and demographic history of Northern Han people in Liaoning Province inferred from genome-wide array data

Population genomics advances in frontier ethnic minorities in China

Dissecting the genetic admixture and forensic signatures of ethnolinguistically diverse Chinese populations via a 114-plex NGS InDel panel

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