Genomic Instability and Cellular Senescence: Lessons From the Budding Yeast

Lee, Jee Whu; Ong, Eugene Boon Beng

doi:10.3389/fcell.2020.619126

Cited by 20 publications

(17 citation statements)

References 128 publications

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“…When SIRT7 is knocked out, the copy number of rDNA is reduced by 50%. [216][217][218] SIRT7 also promotes RNA polymerase binding to the rDNA promoter region and coding region by catalyzing the deacetylation of RNA pol I. 219 Moreover, SIRT7 maintains rDNA repeat stability and nucleolar integrity through the recruitment of DNA methyltransferase 1 and SIRT1.…”

Section: Ribosomes Aging and Neurodegenerative Diseasesmentioning

confidence: 99%

Ribosome biogenesis in disease: new players and therapeutic targets

Jiao

Liu

et al. 2023

Sig Transduct Target Ther

105

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The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome biogenesis is the process that generates ribosomes and plays an essential role in cell proliferation, differentiation, apoptosis, development, and transformation. The mTORC1, Myc, and noncoding RNA signaling pathways are the primary mediators that work jointly with RNA polymerases and ribosome proteins to control ribosome biogenesis and protein synthesis. Activation of mTORC1 is required for normal fetal growth and development and tissue regeneration after birth. Myc is implicated in cancer development by enhancing RNA Pol II activity, leading to uncontrolled cancer cell growth. The deregulation of noncoding RNAs such as microRNAs, long noncoding RNAs, and circular RNAs is involved in developing blood, neurodegenerative diseases, and atherosclerosis. We review the similarities and differences between eukaryotic and bacterial ribosomes and the molecular mechanism of ribosome-targeting antibiotics and bacterial resistance. We also review the most recent findings of ribosome dysfunction in COVID-19 and other conditions and discuss the consequences of ribosome frameshifting, ribosome-stalling, and ribosome-collision. We summarize the role of ribosome biogenesis in the development of various diseases. Furthermore, we review the current clinical trials, prospective vaccines for COVID-19, and therapies targeting ribosome biogenesis in cancer, cardiovascular disease, aging, and neurodegenerative disease.

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Section: Ribosomes Aging and Neurodegenerative Diseasesmentioning

confidence: 99%

Ribosome biogenesis in disease: new players and therapeutic targets

Jiao

Liu

et al. 2023

Sig Transduct Target Ther

105

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“…Model organisms have a relatively shorter generation time and life spans that range from weeks to months, and their smaller sizes are advantageous for laboratory high throughput ageing experiments. Additionally, unicellular organisms such as yeast allow us to study the molecular mechanisms of ageing and senescence at the cellular level [5].…”

Section: Introductionmentioning

confidence: 99%

Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span

Kwong

Lee

Samian

et al. 2021

Cells

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Certain plant extracts (PEs) contain bioactive compounds that have antioxidant and lifespan-extending activities on organisms. These PEs play different roles in cellular processes, such as enhancing stress resistance and modulating longevity-defined signaling pathways that contribute to longevity. Here, we report the discovery of PEs that extended chronological life span (CLS) in budding yeast from a screen of 222 PEs. We identified two PEs, the leaf extracts of Manihot esculenta and Wodyetia bifurcata that extended CLS in a dose-dependent manner. The CLS-extending PEs also conferred oxidative stress tolerance, suggesting that these PEs might extend yeast CLS through the upregulation of stress response pathways.

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“…Loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, altered intercellular communication, and stem cell exhaustion can all contribute to cellular senescence and inflammation. Cellular senescence can impact genomic instability and telomere attrition. − Epigenetic alterations can affect gene expression, including the expression of genes that regulate cell growth and senescence. , For example, certain epigenetic changes can lead to the upregulation of p16 and p21, two proteins that promote cellular senescence One of the consequences of loss of proteostasis is the accumulation of misfolded and damaged proteins.…”

Section: Mechanisms and Physiology Of Agingmentioning

confidence: 99%

Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement

Tenchov,

Sasso,

Wang

et al. 2023

ACS Chem. Neurosci.

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Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Many efforts have been put forth to understand and prevent the effects of aging. Thus, the major cellular and molecular hallmarks of aging have been identified, and their relationships to age-related diseases and malfunctions have been explored. Here, we use data from the CAS Content Collection to analyze the publication landscape of recent aging-related research. We review the advances in knowledge and delineate trends in research advancements on aging factors and attributes across time and geography. We also review the current concepts related to the major aging hallmarks on the molecular, cellular, and organismic level, ageassociated diseases, with attention to brain aging and brain health, as well as the major biochemical processes associated with aging. Major age-related diseases have been outlined, and their correlations with the major aging features and attributes are explored. We hope this review will be helpful for apprehending the current knowledge in the field of aging mechanisms and progression, in an effort to further solve the remaining challenges and fulfill its potential.

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Genomic Instability and Cellular Senescence: Lessons From the Budding Yeast

Cited by 20 publications

References 128 publications

Ribosome biogenesis in disease: new players and therapeutic targets

Ribosome biogenesis in disease: new players and therapeutic targets

Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span

Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement

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