Genomic Landscape and Risk Stratification of Acute Myeloid Leukemia

Hou, Hsin-An

doi:10.1007/978-981-99-3810-0_5

Cited by 1 publication

(2 citation statements)

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“…The incidence of AML is approximately 5.06 per 100,000, and AML in children accounts for about 20% of childhood leukemia cases. 1 It is estimated that 20,240 new cases of AML will be diagnosed in the United States in 2021, and 11,400 people will die of AML. 2 Accordingly, the survival rate is still low.…”

Section: Introductionmentioning

confidence: 99%

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High Expression of VAV Gene Family Predicts Poor Prognosis of Acute Myeloid Leukemia

Long

Guo

et al. 2021

Technol Cancer Res Treat

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Objectives: VAV family genes ( VAV1, VAV2, and VAV3) are associated with prognosis in various cancers; however, they have not been evaluated in acute myeloid leukemia (AML). In this study, the prognostic value of VAV expression in AML was evaluated by a single-center study in combination with bioinformatics analyses. Methods: The expression and prognostic value of VAVs in patients with AML were investigated using various databases, including GEPIA, CCLE, EMBL-EBI, UALCAN, cBioPortal, STRING, and DAVID. Blood samples from 35 patients with AML (non-M3 subtype) and 13 benigh individuals were collected at our center. VAV expression levels were detected by real-time quantitative PCR (RT-qPCR) and western blotting. Clinical data were derived from medical records. Results: Based on data from multiple databases, the expression levels of VAV1, VAV2, and VAV3 were significantly higher in AML than in control tissues ( P < 0.05). RT-qPCR and western blotting results showed that VAV expression in mRNA and protein levels were higher in patients with AML that in the control group ( P < 0.05). Complete remission rates were lower and risks were higher in patients with AML with high VAV1 expression than with low VAV1 expression ( P < 0.05). High levels of VAV2, VAV3, and VAV1 were related to a poor overall survival, and this relationship was significant for VAV1 ( P < 0.05). High expression levels of genes correlated with VAV1, such as SIPA1, SH2D3C, and HMHA1 were also related to a poor prognosis in AML. Functional and pathways enrichment analyses indicated that the contribution of the VAV family to AML may be mediated by the NF-κB, cAMP, and other pathways. Conclusion: VAVs were highly expressed in AML. In particular, VAV1 has prognostic value and is a promising therapeutic target for AML.

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Section: Introductionmentioning

confidence: 99%

“…Therefore, the aim of this study was to explore the expression and prognostic value of VAVs in AML by in vitro and bioinformatics approaches. In particular, we analyzed (1) VAV expression in AML, (2) the relationship between VAV expression and prognosis, and (3) functional enrichment of genes correlated with VAVs.…”

Section: Introductionmentioning

confidence: 99%

High Expression of VAV Gene Family Predicts Poor Prognosis of Acute Myeloid Leukemia

Long

Guo

et al. 2021

Technol Cancer Res Treat

View full text Add to dashboard Cite

show abstract

Genomic Landscape and Risk Stratification of Acute Myeloid Leukemia

Cited by 1 publication

References 416 publications

High Expression of VAV Gene Family Predicts Poor Prognosis of Acute Myeloid Leukemia

High Expression of VAV Gene Family Predicts Poor Prognosis of Acute Myeloid Leukemia

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