Genomic Markers for Ovarian Cancer at Chromosomes 1, 8 and 17 Revealed by Array CGH Analysis

Dimova, Ivanka; Orsetti, Béatrice; Nègre, Vincent; Rougé, Carole; Ursule, Liza; Lasorsa, Laurence; Dimitrov, Rumen; Doganov, N; Тончева, Драга; Theillet, Charles

doi:10.1177/030089160909500315

Cited by 60 publications

(37 citation statements)

References 23 publications

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“…In addition, TBX2 was amplified in pancreatic cancer cell lines [10]. It has been reported that TBX2 is a specific genomic marker for late-stage ovarian cancers [12]. Similarly, TBX2 has also been recognized as prognostic markers in bladder cancer [13].…”

Section: Discussionmentioning

confidence: 96%

High TBX2 expression predicts poor prognosis in non-small cell lung cancer

Zhang¹,

Guo²

2014

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Deregulated expression of T-box2 (TBX2) has been implicated in malignancies. However, the expression pattern and the role of TBX2 in non-small cell lung cancer (NSCLC) remain unclear. The aim of this study was to explore the clinical value of TBX2 in patients with NSCLC. We examined TBX2 expression in 40 NSCLC tissues and matched adjacent noncancerous tissues by quantitative RT-PCR (qRT-PCR) and Western blotting. Furthermore, the TBX2 protein expression was analyzed by immunohistochemistry in 416 NSCLC samples. Kaplan-Meier method and multivariate Cox regression model were used to evaluate the prognostic value of TBX2 expression in NSCLC for disease survival. The expression of TBX2 was significantly elevated in NSCLC tissues as compared with adjacent non-cancerous tissues (P<0.001). The high expression of TBX2 in NSCLC was significantly correlated with lymph node metastasis and tumor node metastasis (TNM) stage. Kaplan-Meier survival analysis revealed that high expression of TBX2 correlated with poor prognosis of NSCLC patients (P<0.01). Multivariate analysis showed that TBX2 expression was an independent prognostic marker for overall survival of NSCLC patients (HR=2.21, 95%CI=1.349-3.905, P=0.0015). Our results suggest that high TBX2 expression is associated with poor prognosis of NSCLC patients, and TBX2 may be a prognostic biomarker for NSCLC.

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Section: Discussionmentioning

confidence: 96%

High TBX2 expression predicts poor prognosis in non-small cell lung cancer

Zhang¹,

Guo²

2014

neo

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“…LIM and SH3 protein 1 mRNA is expressed ubiquitously at low basal levels in all normal human tissues, but is overexpressed in metastatic human breast cancer (Grunewald and Butt, 2008) and ovarian cancer (Grunewald et al, 2007b;Dimova et al, 2009). In a recent case -control study, LASP-1-expression correlated significantly with tumour size and nodal-positivity (Grunewald et al, 2007a).…”

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confidence: 98%

Nuclear localisation of LASP-1 correlates with poor long-term survival in female breast cancer

et al. 2010

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BACKGROUND: LIM and SH3 protein 1 (LASP-1) is a nucleo-cytoplasmatic signalling protein involved in cell proliferation and migration and is upregulated in breast cancer in vitro studies have shown that LASP-1 might be regulated by prostate-derived ETS factor (PDEF), p53 and/or LASP1 gene amplification. This current study analysed the prognostic significance of LASP-1 on overall survival (OS) in 177 breast cancer patients and addressed the suggested mechanisms of LASP-1-regulation. METHODS: Nucleo-cytoplasmatic LASP-1-positivity of breast carcinoma samples was correlated with long-term survival, clinicopathological parameters, Ki67-positivity and PDEF expression. Rate of LASP1 amplification was determined in micro-dissected primary breast cancer cells using quantitative RT -PCR. Cell-phase dependency of nuclear LASP-1-localisation was studied in synchronised cells. In addition, LASP-1, PDEF and p53 expression was compared in cell lines of different tumour entities to define principles for LASP-1-regulation. RESULTS: We showed that LASP-1 overexpression is not due to LASP1 gene amplification. Moreover, no correlation between p53-mutations or PDEF-expression and LASP-1-status was observed. However, nuclear LASP-1-localisation in breast carcinomas is increased during proliferation with peak in G2/M-phase and correlated significantly with Ki67-positivity and poor OS. CONCLUSION: Our results provide evidence that nuclear LASP-1-positivity may serve as a negative prognostic indicator for long-term survival of breast cancer patients.

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“…Both common and rare CNV regions may contribute to the development of cancer, and studies on CNV will be helpful for the treatment and chemoprevention of human ovarian cancer. To date, most investigations of CNV have been conducted using established cancer cell lines (Feuk et al, 2006;Grunewald et al, 2006;Dimova et al, 2009) because of difficulties in obtaining fresh human cancerous tissues. To allow in vivo studies, suitable animal models have been utilized.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, LASP1, whose gene is located between 3,962,872 and 3,987,989 on chicken chromosome 27, is an actinbinding protein involved in peripheral cell extensions of epithelial cancer cells (Schreiber et al, 1998), and its inhibition disturbs the proliferation and migration of breast cancer cells (Grunewald et al, 2006). Based on array CGH analysis of human ovarian cancer, LASP1 is a strong candidate for an inducer of ovarian tumorigenesis (Dimova et al, 2009). …”

Section: Discussionmentioning

confidence: 99%

Large-Scale Copy-Number Alterations in Chicken Ovarian Cancer

Seo¹,

Choi²,

Yun³

et al. 2010

Journal of Animal Science and Technology

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Copy-number variation (CNV) in particular genomic segments owing to deletions or duplications can induce changes in cellular gene expression patterns and may increase susceptibility to diseases such as cancer. The aim of this study was to examine CNVs related to the incidence of epithelial ovarian cancer in chickens. Genomic DNA was extracted from blood cells and cancerous ovaries collected from four 120-week-old White Leghorn chickens and were used for array-based comparative genome hybridization (CGH) analysis. As a result, 25 amplified and 10 deleted CNV regions were detected in chicken ovarian cancer. Of these, 10 amplified and two deleted CNV regions contained genes associated with human ovarian cancer. Our study using a chicken model may provide a better understanding of human epithelial ovarian cancer.

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Genomic Markers for Ovarian Cancer at Chromosomes 1, 8 and 17 Revealed by Array CGH Analysis

Abstract: Our study has identified potential genomic markers of interest on chromosomes 1, 8 and 17 in ovarian cancer. Tumors showed a wide variety in the patterns of alteration, suggesting that alternative mechanisms of genomic instability may play a role in this tumor type.

Cited by 60 publications

References 23 publications

High TBX2 expression predicts poor prognosis in non-small cell lung cancer

High TBX2 expression predicts poor prognosis in non-small cell lung cancer

Nuclear localisation of LASP-1 correlates with poor long-term survival in female breast cancer

Large-Scale Copy-Number Alterations in Chicken Ovarian Cancer

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