Genomic Medicine: New Frontiers and New Challenges

Abstract

BACKGROUND:The practice of personalized medicine has made large strides since the introduction of highthroughput technologies and the vast improvements in computational biotechnology. The personalizedmedicine approach to cancer management holds promise for earlier disease detection, accurate prediction of prognosis, and better treatment options; however, the early experience with personalized medicine has revealed important concerns that need to be addressed before research findings can be translated to the bedside.CONTENT: We discuss several emerging "practical" or "focused" applications of personalized medicine. Molecular testing can have an important positive impact on health and disease management in a number of ways, and the list of specific applications is evolving. This list includes improvements in risk assessment, disease prevention, identification of new diseaserelated mutations, accurate disease classification based on molecular signatures, selection of patients for enrollment in clinical trials, and development of new targeted therapies, especially for metastatic tumors that are refractory to treatment. Several challenges remain to be addressed before genomics information can be applied successfully in the routine clinical management of cancers. Further improvements and investigations are needed in data interpretation, extraction of actionable items, costeffectiveness, how to account for patient heterogeneity and ethnic variation, and how to handle the risk of "incidental findings" in genetic testing.

Serious Games for Improving Genetic Literacy and Genetic Risk Awareness in the General Public: Protocol for a Randomized Controlled Trial (Preprint)

“…Unfortunately, even well-educated people lack understanding of these concepts [38]. As described in the introduction the current matter is that genetic testing and genetic risk information have become the new frontier of personalized medicine and disease prevention [39]. Moreover, with the introduction of DTC-GT, people evaluate the credibility and utility of genetic information, which has implications for personal and public health, as they do this autonomously without having acquired this skill [40].…”

Secuenciación De Próxima Generación Y Su Contexto Eugenésico en El Embrión Humano

“…El análisis de genomas personales instauró y consolidó un nuevo campo de la medicina contemporánea, el cual utiliza la información genómica, individual y específica de una persona en particular como base para, primero, detectar las alteraciones genómicas que pueden estar asociadas con el desarrollo o progreso de enfermedades específicas y, posteriormente, delinear estrategias, tratamientos y drogas diseñadas a la medida de las necesidades de dicho paciente en particular. De esta manera, la medicina deja de ser un oficio de soluciones masivas, para evolucionar a una ciencia que se ajusta a su paciente como un traje diseñado a la medida (7,(29)(30)(31)(32)(33).…”

Exosomes in semen: opportunities as a new tool in prostate cancer diagnosis

“…Liquid biopsy and in particular seminal exosomes (SE) recovered by seminal fluid (SF) could represent an important innovation in the field of precision medicine. Precision medicine can be applied in screening, diagnosis, prognosis, prediction of treatment response and resistance, early detection of metastasis and biologic cancer stratification (2).…”