Genomic profile of TdT^positiveMYC/BCL2 rearranged high‐grade B‐cell lymphoma supporting its diagnosis as mature aggressive lymphoma

Clinicopathologic features of relapsed CD19(−) B‐ALL in CD19‐targeted immunotherapy: Biological insights into relapse and LILRB1 as a novel B‐cell marker for CD19(−) B lymphoblasts

“…Next generation sequencing (NGS) study was performed on bone marrow aspirate from 2 cases, patient 1 in CD19(+) B-ALL prior to anti-CD19 therapy using the FoundationOne panel and patient 5 in CD19(À) B-ALL following anti-CD19 therapy using our institutional panel that covers all exons of 1505 genes. 27 3 | RESULTS loss of CD19. Importantly, LILRB1 was variably expressed on B lymphoblasts in all CD19(À) post-B-ALL but with an aberrant expression pattern, that is, loss of the dynamic V-shaped pattern in contrast to hematogones.…”

“…Next generation sequencing (NGS) study was performed on bone marrow aspirate from 2 cases, patient 1 in CD19(+) B‐ALL prior to anti‐CD19 therapy using the FoundationOne panel and patient 5 in CD19(−) B‐ALL following anti‐CD19 therapy using our institutional panel that covers all exons of 1505 genes 27 …”

Dual Self-Amplification Homogeneous Electrochemiluminescence Biosensor for Terminal Deoxynucleotidyl Transferase Activity Based on Controlling the Surface Morphology and Charge of Reporter Nanoparticles

“…Terminal deoxynucleotidyl transferase (TdT) is a template-independent DNA polymerase that has a special function that can catalyze the random polymerization of nucleotides at the 3′-hydroxyl (OH) termini of single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) chains. , Existing studies demonstrated that TdT is expressed at low levels in normal human cells while exhibiting high activity in various leukemia cells, particularly in acute lymphoblastic leukemia (ALL) cells. − Furthermore, TdT expression levels vary among different types and stages of leukemia cells . Consequently, TdT can serve as a diagnostic biomarker and potential therapeutic target for ALL, , facilitating precise classification and risk stratification of leukemia in conjunction with other clinical diagnostic methods.…”