Genomic Regions and Candidate Genes Linked to Capped Hock in Pig

Getmantseva, Lyubov; Kolosova, Maria; Bakoev, Faridun; Zimina, Anna; Bakoev, Siroj

doi:10.3390/life11060510

Cited by 7 publications

(6 citation statements)

References 35 publications

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“…Dysregulation of adhesion molecules often causes various diseases, including inflammation and tumors [ 31 , 32 , 33 ]. Earlier, we also suggested a hypothesis about the connection of cadregins with Capped Hock in Pig [ 34 ]. In the future, it is vital to study cadregins in more detail in terms of limb tumors since this is a source of significant economic losses in pig production [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 92%

Investigation of the Genetic Architecture of Pigs Subjected to Breeding Intensification

Kolosov

Getmantseva

Kolosova

et al. 2022

Genes

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Pigs are strategically important animals for the agricultural industry. An assessment of genetic differentiation between pigs, undergone and not undergone to selection intensification, is of particular interest. Our research was conducted on two groups of Large White pigs grown on the same farm but in different years. A total of 165 samples were selected with 78 LW_А (n = 78, the Russian selection) and LW_B (n = 87, a commercial livestock). For genotyping, we used GeneSeek® GGP Porcine HD Genomic Profiler v1 (Illumina Inc, San Diego, CA, USA). To define breeding characteristics of selection, we used smoothing FST and segment identification of HBD (Homozygous-by-Descent). The results of smoothing FST showed 20 areas of a genome with strong ejection regions of the genome located on all chromosomes except SSC2, SSC3, and SSC8. The average realized autozygosity in Large White pigs of native selection was in (LW_A)—0.21, in LW_В—0.29. LW_А showed 13,338 HBD segments, 171 per one animal, and LW_B—15,747 HBD segments, 181 per one animal. The ejections found by the smoothing FST method were partially localized in the HBD regions. In these areas, the genes ((NCBP1, PLPPR1, GRIN3A, NBEA, TRPC4, HS6ST3, NALCN, SMG6, TTC3, KCNJ6, IKZF2, OBSL1, CARD10, ETV6, VWF, CCND2, TSPAN9, CDH13, CEP128, SERPINA11, PIK3CG, COG5, BCAP29, SLC26A4) were defined. The revealed genes can be of special interest for further studying their influence on an organism of an animal since they can act as candidate genes for selection-significant traits.

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Section: Discussionmentioning

confidence: 92%

Investigation of the Genetic Architecture of Pigs Subjected to Breeding Intensification

Kolosov

Getmantseva

Kolosova

et al. 2022

Genes

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“…By targeted selection at the end of the 19th century, the Landrace breed was created in Denmark. In recent decades, the commercial pig breeding industry has triggered significant changes in selection programs with a focus on the cost effectiveness of production [ 23 , 24 , 25 , 26 , 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Homozygous-by-Descent (HBD) Segments for Purebred and Crossbred Pigs in Russia

Bakoev

Kolosov

Bakoev

et al. 2021

Life

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Intensive selection raises the efficiency of pig farming considerably, but it also promotes the accumulation of homozygosity, which can lead to an increase in inbreeding and the accumulation of deleterious variation. The analysis of segments homozygous-by-descent (HBD) and non-HBD segments in purebred and crossbred pigs is of great interest. Research was carried out on 657 pigs, of which there were Large White (LW, n = 280), Landrace (LR, n = 218) and F1 female (♂LR × ♀LW) (F1, n = 159). Genotyping was performed using the GeneSeek® GGP Porcine HD Genomic Profiler v1 (Illumina Inc., USA). To identify HBD segments and estimate autozygosity (inbreeding coefficient), we used the multiple HBD classes model. LW pigs exhibited 50,420 HBD segments, an average of 180 per animal; LR pigs exhibited 33,586 HBD segments, an average of 154 per animal; F1 pigs exhibited 21,068 HBD segments, an average of 132 per animal. The longest HBD segments in LW were presented in SSC1, SSC13 and SSC15; in LR, in SSC1; and in F1, in SSC15. In these segments, 3898 SNPs localized in 1252 genes were identified. These areas overlap with 441 QTLs (SSC1—238 QTLs; SSC13—101 QTLs; and SSC15—102 QTLs), including 174 QTLs for meat and carcass traits (84 QTLs—fatness), 127 QTLs for reproduction traits (100 QTLs—litter traits), 101 for production traits (69 QTLs—growth and 30 QTLs—feed intake), 21 QTLs for exterior traits (9 QTLs—conformation) and 18 QTLs for health traits (13 QTLs—blood parameters). Thirty SNPs were missense variants. Whilst estimating the potential for deleterious variation, six SNPs localized in the NEDD4, SEC11C, DCP1A, CCT8, PKP4 and TENM3 genes were identified, which may show deleterious variation. A high frequency of potential deleterious variation was noted for LR in DCP1A, and for LW in TENM3 and PKP4. In all cases, the genotype frequencies in F1 were intermediate between LR and LW. The findings presented in our work show the promise of genome scanning for HBD as a strategy for studying population history, identifying genomic regions and genes associated with important economic traits, as well as deleterious variation.

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“…With adopting genomic selection most of the purebred elite lines of farm animals are genotyped using biochips with high and medium density [2]. As a rule, such methods as the genomewide association study (GWAS) and/or the Selection Signature Analysis [3] are used to evaluate the effects of selection based on the analysis of genomic data. These methods are successfully applied to identify genomic regions in rigorously selected farm animals.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of genetic differentiation and search for candidate genes for reproductive traits in pigs

Romanets,

Bakoev,

Romanets

et al. 2024

Anim Biosci

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Objective: The use of molecular genetic methods in pig breeding can significantly increase the efficiency of breeding and breeding work. We applied the Fst (fixsacion index) method, the main focus of the work was on the search for common options related to the number of born piglets and the weight of born piglets, since today the urgent task is to prevent a decrease in the weight of piglets at birth while maintaining high fertility of sows.Methods: One approach is to scan the genome, followed by an assessment of Fst and identification of selectively selected regions. We chose Large White sows (n = 237) with the same conditions of keeping and feeding. The data were collected from the sows across three farrowing. For genotyping, we used GeneSeek GGP Porcine HD Genomic Profiler v1, which included 68,516 single nucleotide polymorphisms evenly distributed with an average spacing of 25 kb (Illumina Inc, San Diego, CA, USA).Results: Based on the results of the Fst analysis, 724 variants representing selection signals for the signs BALWT, BALWT1, NBA, and TNB (weight of piglets born alive, average weight of the 1st piglets born alive, total number born alive, total number born). At the same time, 18 common variants have been identified that are potential markers for both the number of piglets at birth and the weight of piglets at birth, which is extremely important for breeding work to improve reproductive characteristics in sows.Conclusion: Оur work resulted in identification of variants associated with the reproductive characteristics of pigs. Moreover, we identified, variants which are potential markers for both the number of piglets at birth and the weight of piglets at birth, which is extremely important for breeding work to improve reproductive performance in sows.

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Genomic Regions and Candidate Genes Linked to Capped Hock in Pig

Cited by 7 publications

References 35 publications

Investigation of the Genetic Architecture of Pigs Subjected to Breeding Intensification

Investigation of the Genetic Architecture of Pigs Subjected to Breeding Intensification

Analysis of Homozygous-by-Descent (HBD) Segments for Purebred and Crossbred Pigs in Russia

Evaluation of genetic differentiation and search for candidate genes for reproductive traits in pigs

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