Genomic regions responsible for manganese superoxide dismutase regulation in <i>Drosophila melanogaster</i>

Paul, Anirban; Duttaroy, Atanu

doi:10.1046/j.1474-9728.2003.00056.x

Cited by 5 publications

(2 citation statements)

References 40 publications

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“…KG06854R shares the same genetic background as Sod2 n283 . 47 Chi-square independence test was performed at 95% confidence interval by feeding the data into the University of Kansas web site http:// www.people.ku.edu/~preacher/chisq/chisq.html.…”

Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

SOD2, the principal scavenger of mitochondrial superoxide, is dispensable for embryogenesis and imaginal tissue development but essential for adult survival

Mukherjee

Forde

Belton

et al. 2011

Fly

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Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

SOD2, the principal scavenger of mitochondrial superoxide, is dispensable for embryogenesis and imaginal tissue development but essential for adult survival

Mukherjee

Forde

Belton

et al. 2011

Fly

Self Cite

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“…Shen, Li, et al ( 2013 ) and Shen, Xiao, et al ( 2013 ) reported that D. melanogaster has a region that encodes enhancement of SOD activity and four regions that encode suppression of SOD activity. Disruption of gene encoding SOD in D. melanogaster has been shown to reduce SOD activity (Paul & Duttaroy, 2003 ; Woodruff‐Pak et al, 2001 ). Overexpression of this gene, however, resulted in increased SOD activity in D. melanogaster (Aigaki et al, 2002 ; Sun et al, 2004 ).…”

Section: Discussionmentioning

confidence: 99%

African Jointfir (Gnetum africanum) and Editan (Lasianthera africana) leaf alkaloid extracts exert antioxidant and anticholinesterase activities in fruit fly (Drosophila melanogaster)

Oboh

Atoki

Ademiluyi

et al. 2023

Food Science & Nutrition

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African Jointfir (Gnetum africanum) and Editan (Lasianthera africana) leaves are two leafy green veggies with several nutritional and medicinal properties. Alzheimer's disease (AD) is a form of neurodegeneration that is believed to cause dementia in affected individuals. The quest for alternative treatments has necessitated the exploitation of plants' secondary metabolites. Plant alkaloids have recently demonstrated relevance in the management of a variety of neurodegenerative disorders; although there is limited information on the neuroprotective properties of alkaloids from various tropical green leafy vegetables with neuroprotective potentials. As a result, this study examined the cholinesterase inhibitory activity and antioxidant potential of alkaloid extracts from the leaves of African Jointfir (G. africanum) and Editan (L. africana). Standard solvent extraction techniques were used to prepare alkaloid extracts. After that, these extracts were characterized using high‐performance liquid chromatography. In vitro acetylcholinesterase inhibition assay for the extracts was also carried out. Subsequently, the alkaloid extracts were included in the diets of these flies (2 and 10 μg/g) for 7 days. Thereafter, treated fly homogenates were assayed for cholinesterase, monoamine oxidase, and antioxidant enzymes (specifically, glutathione‐S‐transferase catalase, and superoxide dismutase) activities, in addition, thiobarbituric acid reactive substance, reactive oxygen species, and total thiol contents. The extracts showed considerable anticholinesterase, antioxidant, and antimonoamine oxidase capabilities, according to the study's findings. Also, HPLC characterization revealed that desulphosinigrin (597,000 ng/100 g) and atropine (44,200 ng/100 g) are the predominating phytochemicals in Editan and African Jointfir respectively. These extracts could serve as potential sources of nutraceuticals with neuroprotective properties which can be used in the treatment/management of Alzheimer's disease.

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Molecular and biochemical characterization of manganese-containing superoxide dismutase from the silkworm, Bombyx mori

Yamamoto

Zhang

et al. 2005

Comparative Biochemistry and Physiology Part B: Biochemistry an

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Genomic regions responsible for manganese superoxide dismutase regulation in Drosophila melanogaster

Abstract: SummaryThe transcription of manganese superoxide dismutase ( MnSOD ), expression of which is essential for detoxification of superoxide radicals from mitochondria, has been shown to be regulated in vitro by many factors and conditions including oxidative stress, cytokines, lipopolysac-

Cited by 5 publications

References 40 publications

SOD2, the principal scavenger of mitochondrial superoxide, is dispensable for embryogenesis and imaginal tissue development but essential for adult survival

SOD2, the principal scavenger of mitochondrial superoxide, is dispensable for embryogenesis and imaginal tissue development but essential for adult survival

African Jointfir (Gnetum africanum) and Editan (Lasianthera africana) leaf alkaloid extracts exert antioxidant and anticholinesterase activities in fruit fly (Drosophila melanogaster)

Molecular and biochemical characterization of manganese-containing superoxide dismutase from the silkworm, Bombyx mori

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