2013
DOI: 10.2741/s379
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Genomic stability disorders from budding yeast to humans

Abstract: Fundamental aspects of eukaryotic molecular and cellular biology are extensively studied in the budding yeast Saccharomyces cerevisiae. Genome maintenance pathways are highly conserved and research into a number of human genetic disorders with increased genome instability and cancer predisposition have benefited greatly from studies in budding yeast. Here, we present some of the examples where yeast research into DNA damage responses and telomere maintenance pathways paved the way to understanding these proces… Show more

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Cited by 2 publications
(2 citation statements)
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“…Telomeres are involved in maintaining genomic stability [ 30 ]. In the current study, we investigated the impact of hTERT variants on BC risk in a sample of the Iranian population in southeast Iran.…”
Section: Resultsmentioning
confidence: 99%
“…Telomeres are involved in maintaining genomic stability [ 30 ]. In the current study, we investigated the impact of hTERT variants on BC risk in a sample of the Iranian population in southeast Iran.…”
Section: Resultsmentioning
confidence: 99%
“…Due to the linear nature of eukaryotic chromosomes, their ends must be protected in order to prevent the progressive loss of sequence with each round of cell division, which can eventually lead to genomic instability, disease, and cell death [1,2]. Telomeres are the nucleoprotein structures found at the ends of linear chromosomes that serve as protective caps, prevent chromosomal ends from being treated as double-strand breaks, and counteract telomere shortening during replication [3,4].…”
Section: Introductionmentioning
confidence: 99%