Genomics, histopathology, and the tumor microenvironment: new relationship or old friends re-discovered?

Visscher, Daniel W.

doi:10.1007/s10549-010-0930-z

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…Despite a major focus on malignant cells, non-cancerous cells, such as stromal and immune cells, play significant roles in tumor formation and treatment responses [ 126 ]. Ongoing evolutionary and ecological processes have been demonstrated, including constant interaction between cancer cells and the tumor microenvironment (TME).…”

Section: Clinical Applications Of Single-cell Rna Sequencingmentioning

confidence: 99%

Single-Cell RNA Sequencing: Technological Progress and Biomedical Application in Cancer Research

Zheng

2023

Mol Biotechnol

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Single-cell RNA-seq (scRNA-seq) is a revolutionary technology that allows for the genomic investigation of individual cells in a population, allowing for the discovery of unusual cells associated with cancer and metastasis. ScRNA-seq has been used to discover different types of cancers with poor prognosis and medication resistance such as lung cancer, breast cancer, ovarian cancer, and gastric cancer. Besides, scRNA-seq is a promising method that helps us comprehend the biological features and dynamics of cell development, as well as other disorders. This review gives a concise summary of current scRNA-seq technology. We also explain the main technological steps involved in implementing the technology. We highlight the present applications of scRNA-seq in cancer research, including tumor heterogeneity analysis in lung cancer, breast cancer, and ovarian cancer. In addition, this review elucidates potential applications of scRNA-seq in lineage tracing, personalized medicine, illness prediction, and disease diagnosis, which reveals that scRNA-seq facilitates these events by producing genetic variations on the single-cell level.

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Section: Clinical Applications Of Single-cell Rna Sequencingmentioning

confidence: 99%

Single-Cell RNA Sequencing: Technological Progress and Biomedical Application in Cancer Research

Zheng

2023

Mol Biotechnol

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“…Therefore, coadministration of collagenase by a localized delivery system could be a potential strategy to enhance the penetration of antibody within stroma-rich solid tumors (e.g. breast cancers) (Provenzano et al., 2008 ; Visscher, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Localized co-delivery of collagenase and trastuzumab by thermosensitive hydrogels for enhanced antitumor efficacy in human breast xenograft

et al. 2018

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Modulation of the collagen-rich extracellular matrix (ECM) in solid tumors by the treatment with collagenase has been proved effective in enhancement of the interstitial transport and antitumor efficacy of antibodies. We, therefore, developed a PLGA-PEG-PLGA polymer-based thermosensitive hydrogel, which incorporated a HER2-targeted monoclonal antibody trastuzumab and collagenase (Col/Tra/Gel) for peritumoral administration. HER2-positvie BT474 tumor-bearing mice were selected as a model. The Col/Tra/Gel showed the continuous and biphasic release of protein drugs for 9 days in vitro. NIR imaging studies demonstrated a long-term retention of Col/Tra/Gel hydrogel in the peritumoral area for over 20 days. Treatment with Col/Tra/Gel reduced the collagen density and enhanced apoptotic cell death in tumor tissue, resulting in superior treatments with increased efficacy and reduced toxicity compared with other control groups. Moreover, a quarter-dose of Col/Tra/Gel exhibited a better antitumor efficacy than that of intravenous injection of clinical trastuzumab formulation. This localized co-delivery system offers a potential strategy for the modulation of dense ECM and enhancement of antibody efficacy.

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Genomics, histopathology, and the tumor microenvironment: new relationship or old friends re-discovered?

Cited by 2 publications

References 7 publications

Single-Cell RNA Sequencing: Technological Progress and Biomedical Application in Cancer Research

Single-Cell RNA Sequencing: Technological Progress and Biomedical Application in Cancer Research

Localized co-delivery of collagenase and trastuzumab by thermosensitive hydrogels for enhanced antitumor efficacy in human breast xenograft

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