Genomics of SCC: Tumor Formation, Progression, and Future Therapeutic Implications for High-Risk Cutaneous Squamous Cell Carcinoma

Harwood, Catherine A.; Proby, Charlotte M.; Arron, Sarah T.

doi:10.1007/978-3-662-47081-7_3

Cited by 3 publications

(5 citation statements)

References 187 publications

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“…cSCCs have the highest tumor mutation burden among malignancies harboring, on average, ≈50 mutations per megabase pair (Mbp) of DNA [ 15 , 26 , 27 , 28 ]. It is hypothesized that most of these mutations are “passengers”, offering little-to-no growth advantage nor impact on tumor progression, while a subset represent “driver mutations” that promote tumorigenesis by regulating cell fate, growth, survival, or genomic maintenance [ 9 ]. Whole exome and targeted sequencing analyses of unremarkable skin, AKs, SCCIS, and cSCCs provide evidence that numerous driver pathways act preferentially at specific stages to promote tumorigenesis [ 20 , 29 , 30 , 31 , 32 , 33 , 34 ].…”

Section: Genetic Alterations In Csccmentioning

confidence: 99%

“…However, in human patients with UV-induced DNA damage, GOF Ras alterations are exceedingly rare in AKs/SCCIS, and are encountered predominantly in a small subset of late-stage cSCCs [ 33 , 34 , 73 ]. As such, Ras genes are not generally regarded as oncogenes driving the early stages of cSCC development [ 9 ].…”

Section: Genetic Alterations In Csccmentioning

confidence: 99%

“…A small percentage of AKs, incidentally, acquire additional genetic and epigenetic changes and progress to cutaneous squamous cell carcinoma in situ (SCCIS) and ultimately cSCC, both of which are clinically larger lesions, similarly characterized histologically by the presence of parakeratosis, with more pronounced dysplasia wherein the full thickness of the epidermis is replaced by malignant keratinocytes that are either bounded by the basement membrane in the case of SCCIS, or invade the dermis and surrounding structures in the case of cSCC [ 5 ]. A small subset of cSCC may acquire additional genetic and epigenetic features that lead to metastatic disease [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Molecularly, cSCC arises from the accumulation of genetic and epigenetic alterations in keratinocytes over time that permit development of an invasive tumor [ 9 ]. The accumulation of genetic alterations, and development of malignant and premalignant lesions, is accelerated when intrinsic defenses are compromised.…”

Section: Introductionmentioning

confidence: 99%

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Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma

Hedberg

Berry

Moshiri

et al. 2022

IJMS

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Non-melanoma skin cancers are cutaneous malignancies representing the most common form of cancer in the United States. They are comprised predominantly of basal cell carcinomas and squamous cell carcinomas (cSCC). The incidence of cSCC is increasing, resulting in substantial morbidity and ever higher treatment costs; currently in excess of one billion dollars, per annum. Here, we review research defining the molecular basis and development of cSCC that aims to provide new insights into pathogenesis and drive the development of novel, cost and morbidity saving therapies.

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Section: Genetic Alterations In Csccmentioning

confidence: 99%

Section: Genetic Alterations In Csccmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma

Hedberg

Berry

Moshiri

et al. 2022

IJMS

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“…CSCC results from genetic and epigenetic changes in cell replication during keratinosis. Over time, aggressive tumors accumulate and eventually form ( 5 ). When intracellular defensive abilities are impaired, the accumulation of genetic changes and the development of malignant and precancerous lesions are accelerated ( 6 , 7 ).…”

Section: Introductionmentioning

confidence: 99%

Global status of research on cutaneous squamous cell carcinoma and its programmed cell death: Bibliometric and visual analysis from 2012 to middle 2022

et al. 2023

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ObjectiveThis study was aimed to analyze the research status and development trend of cutaneous squamous cell carcinoma (CSCC), focusing on the field of programmed cell death of CSCC, and providing suggestions for the research of CSCC.MethodsThe publications related to CSCC and CSCC programmed cell death were searched in the Web of Science Core Collection (WOSCC) database, and timespan was set from 2012 to middle 2022. Research trends, authors, major country collaborations, research institutions, representative journals, publishers, and keywords were analyzed with CiteSpace and VOSviewer.ResultsAfter screening, a total of 3656 publications on CSCC and 156 publications on CSCC cell programmed death were obtained. The number of published articles increased gradually with the years. The United States ranked first in terms of the number of published papers. Research in this field had focused on dermatology. Most of the institutions in both regions were from European and American countries. Harvard University was the most prolific institution. Wiley was the most prolific publisher. The popular keywords for programmed cell death in CSCC were cutaneous squamous cell carcinoma, diagnosis, pd 1, head, nivolumab and risk. Keywords in CSCC field were divided into 7 clusters: cutaneous squamous cell carcinoma, sentinel lymph node biopsy, skin cancer, B-Raf Proto-Oncogene, Serine/Threonine Kinase (BRAF) inhibitor and human Papillomaviruses, and P63 expression. Squamous cell carcinoma, cancer, head and expression were the most popular keywords. The popular keywords for programmed cell death in CSCC were cutaneous squamous cell carcinoma, diagnosis, pd 1, head, nivolumab and risk.ConclusionThis study analyzed the research status of cutaneous squamous cell carcinoma and programmed cell death from 2012 to middle 2022. Understanding research status and hotspots can help scholars, countries and policymakers to better understand the background and research frontier of CSCC, and guide further research directions.

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Ultraviolet (UV) radiation: a double-edged sword in cancer development and therapy

Yu,

Zheng,

Fan

et al. 2024

Mol Biomed

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It has long been widely acknowledged that ultraviolet (UV) light is an environment risk factor that can lead to cancer, particularly skin cancer. However, it is worth noting that UV radiation holds potential for cancer treatment as a relatively high-energy electromagnetic wave. With the help of nanomaterials, the role of UV radiation has caught increasing attention in cancer treatment. In this review, we briefly summarized types of UV-induced cancers, including malignant melanoma, squamous cell carcinoma, basal cell carcinoma, Merkel cell carcinoma. Importantly, we discussed the primary mechanisms underlying UV carcinogenesis, including mutations by DNA damage, immunosuppression, inflammation and epigenetic alterations. Historically limited by its shallow penetration depth, the introduction of nanomaterials has dramatically transformed the utilization of UV light in cancer treatment. The direct effect of UV light itself generally leads to the suppression of cancer cell growth and the initiation of apoptosis and ferroptosis. It can also be utilized to activate photosensitizers for reactive oxygen species (ROS) production, sensitize radiotherapy and achieve controlled drug release. Finally, we comprehensively weigh the significant risks and limitations associated with the therapeutic use of UV radiation. And the contradictory effect of UV exposure in promoting and inhibiting tumor has been discussed. This review provides clues for potential clinical therapy as well as future study directions in the UV radiation field. The precise delivery and control of UV light or nanomaterials and the wavelength as well as dose effects of UV light are needed for a thorough understanding of UV radiation.

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Genomics of SCC: Tumor Formation, Progression, and Future Therapeutic Implications for High-Risk Cutaneous Squamous Cell Carcinoma

Cited by 3 publications

References 187 publications

Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma

Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma

Global status of research on cutaneous squamous cell carcinoma and its programmed cell death: Bibliometric and visual analysis from 2012 to middle 2022

Ultraviolet (UV) radiation: a double-edged sword in cancer development and therapy

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