Genomics, Proteomics, and Metabolomics of Cancer Stem Cells (CSCs)

Khatami, Fatemeh; Tavangar, Seyed Mohammad; Pour, Navaz Karimian

doi:10.1007/978-3-030-27727-7_9

Cited by 2 publications

(2 citation statements)

References 139 publications

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“…In fact, the diagnostic and prognostic utility of liquid biopsy has been proven in the more aggressive MTC and ATC 23 24 . Further understanding of the tumoral DNA natural history can refine the clinical utility of this promising non-invasive technique 25 26 .…”

Section: Introductionmentioning

confidence: 99%

Updates on the Management of Thyroid Cancer

2020

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The diagnostic modalities, stratification tools, and treatment options for patients with thyroid cancer have rapidly evolved since the development of the American Thyroid Association (ATA) guidelines in 2015. This review compiles newer concepts in diagnosis, stratification tools and treatment options for patients with differentiated thyroid cancer (DTC), medullary thyroid carcinoma (MTC) and anaplastic thyroid cancer (ATC). Newer developments apply precision medicine in thyroid cancer patients to avoid over-treatment in low risk disease and under-treatment in high risk disease. Among novel patient-tailored therapies are selective RET inhibitors that have shown efficacy in the treatment of MTC with limited systemic toxicity compared with non-specific tyrosine kinase inhibitors. The combination of BRAF and MEK inhibitors have revolutionized management of BRAF V600E mutant ATC. Several immunotherapeutic agents are being actively investigated in the treatment of all forms of thyroid cancer. In this review, we describe the recent advances in the diagnosis and management of DTC, MTC, and ATC, with an emphasis on novel treatment modalities.

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Section: Introductionmentioning

confidence: 99%

Updates on the Management of Thyroid Cancer

2020

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“…Furthermore, evaluating cell surface markers is the main strategy for detecting CSCs. Normal stem cells and CSCs have many similar characteristics ( Jin et al, 2017 ; Khatami et al, 2019 ) such as 1) Self-Renewal ( Lobo et al, 2007 ) 2) Differentiation capacity ( Mohr et al, 2015 ) 3) Tumorigenesis ( Zhu and Fan, 2018 ) 4) Capacity of developing resistance to drugs/cytotoxic substances and radiation ( Schöning et al, 2017 ). Despite their similarities, there are some distinctions between cancer and somatic stem cells.…”

Section: The Biology Of Cancer Stem Cellsmentioning

confidence: 99%

Molecular Docking as a Therapeutic Approach for Targeting Cancer Stem Cell Metabolic Processes

et al. 2022

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Cancer stem cells (CSCs) are subpopulation of cells which have been demonstrated in a variety of cancer models and involved in cancer initiation, progression, and development. Indeed, CSCs which seem to form a small percentage of tumor cells, display resembling characteristics to natural stem cells such as self-renewal, survival, differentiation, proliferation, and quiescence. Moreover, they have some characteristics that eventually can demonstrate the heterogeneity of cancer cells and tumor progression. On the other hand, another aspect of CSCs that has been recognized as a central concern facing cancer patients is resistance to mainstays of cancer treatment such as chemotherapy and radiation. Owing to these details and the stated stemness capabilities, these immature progenitors of cancerous cells can constantly persist after different therapies and cause tumor regrowth or metastasis. Further, in both normal development and malignancy, cellular metabolism and stemness are intricately linked and CSCs dominant metabolic phenotype changes across tumor entities, patients, and tumor subclones. Hence, CSCs can be determined as one of the factors that correlate to the failure of common therapeutic approaches in cancer treatment. In this context, researchers are searching out new alternative or complementary therapies such as targeted methods to fight against cancer. Molecular docking is one of the computational modeling methods that has a new promise in cancer cell targeting through drug designing and discovering programs. In a simple definition, molecular docking methods are used to determine the metabolic interaction between two molecules and find the best orientation of a ligand to its molecular target with minimal free energy in the formation of a stable complex. As a comprehensive approach, this computational drug design method can be thought more cost-effective and time-saving compare to other conventional methods in cancer treatment. In addition, increasing productivity and quality in pharmaceutical research can be another advantage of this molecular modeling method. Therefore, in recent years, it can be concluded that molecular docking can be considered as one of the novel strategies at the forefront of the cancer battle via targeting cancer stem cell metabolic processes.

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Genomics, Proteomics, and Metabolomics of Cancer Stem Cells (CSCs)

Cited by 2 publications

References 139 publications

Updates on the Management of Thyroid Cancer

Updates on the Management of Thyroid Cancer

Molecular Docking as a Therapeutic Approach for Targeting Cancer Stem Cell Metabolic Processes

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