Genotoxic and cytotoxic biomonitoring in patients exposed to full mouth radiographs – A radiological and cytological study

Sunitha, K. V. N.; Maloth, Kotya Naik; Reddy, K. Vinay Kumar; Geetha, P. R.

doi:10.4103/jomr.jomr_47_16

Cited by 6 publications

(8 citation statements)

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“…The cytotoxic effects of panoramic and CBCT lead to cell death 3,4,14,15 . Cellular death is believed to be a nongenotoxic mechanism induced by carcinogenesis 1,2 .…”

Section: Discussionmentioning

confidence: 99%

“…Cellular death is believed to be a nongenotoxic mechanism induced by carcinogenesis 1,2 . Genotoxic and cytotoxic X-ray effects on exfoliated buccal mucosal and gingival cells were detected when a series of X-ray dental imaging exams, including full mouth radiograph, panoramic, lateral cephalometric radiographs, posteroanterior cephalometric radiographs, and CBCTs, were performed [14][15][16] . Further, analog panoramic radiographs showed a significant increase in post-exposure micronuclei relative to digital panoramic radiographs 12 .…”

Section: Discussionmentioning

confidence: 99%

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Alteration of mucosa cell maturation pattern after exposure to different radiographic imaging methods

et al. 2021

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Aim: Dental imaging has been widely used for diagnosis in dentistry. However, dental X-ray may induce cytotoxicity leading to apoptosis in oral mucosa cells. The present study aimed to observe the maturation pattern of buccal and gingival cells after exposure to X-ray radiation from analog/digital panoramic scanning and cone beam computed tomography (CBCT). Methods: The research samples were 40 subjects who fulfilled the inclusion and exclusion criteria. The subjects were divided into the exposed (patients who received analog/digital panoramic radiography or CBCT) and controlled (patients who had no radiography examinations) groups, with 10 subjects in each group. Exfoliative cytology smears were obtained from buccal mucosa and gingiva before exposure (or on day 0 for the control group) and 10 days later. The cells were stained with the Papanicolaou method. Then, the superficial, intermediate, and parabasal cells were counted in each glass slide. Results: No significant differences (p > 0.05) were observed among all cell types between day 0 and 10 in the control group. Meanwhile, after exposure to three kinds of radiography examinations, the frequency of intermediate cells in buccal mucosa and gingiva increased (p < 0.05), but that of superficial cells decreased (p < 0.05) significantly. No significant difference was found in the parabasal cells (p > 0.05). The frequency differences between intermediate and superficial cells showed no significant difference between the buccal mucosa and gingiva. Conclusion: Analog/digital panoramic radiography and CBCT exposure can induce cytotoxicity by altering the maturation pattern of buccal mucosa cells and gingiva, so it is strongly recommended to only perform these procedures if necessary and avoid repeated exposure to the same patient.

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“…The cytotoxic effects of panoramic and CBCT lead to cell death 3,4,14,15 . Cellular death is believed to be a nongenotoxic mechanism induced by carcinogenesis 1,2 .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Alteration of mucosa cell maturation pattern after exposure to different radiographic imaging methods

et al. 2021

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“…Hal ini disebabkan karena sel epitel mukosa bukal memiliki rata -rata turnover yang lebih tinggi yaitu 14 hari dan merupakan sel epitel non keratinisasi jika dibandingkan dengan sel epitel mukosa gingiva yang memiliki rata -rata turnover 10 hari dan merupakan sel epitel keratinisasi. 5,7 Sel epitel keratinisasi lebih tahan terhadap trauma fisik dan kimia jika dibandingkan dengan sel epitel non keratinisasi. Sel epitel mukosa gingiva memiliki rata -rata turnover lebih rendah daripada sel epitel mukosa bukal sehingga membuat sel epitel mukosa gingiva lebih tahan terhadap kerusakan DNA akibat paparan radiasi sinar-X.…”

Section: Diskusiunclassified

“…Sel epitel mukosa gingiva memiliki rata -rata turnover lebih rendah daripada sel epitel mukosa bukal sehingga membuat sel epitel mukosa gingiva lebih tahan terhadap kerusakan DNA akibat paparan radiasi sinar-X. 7 Pernyataan tersebut sesuai dengan hasil penelitian yang menyatakan bahwa rerata jumlah peningkatan mikronukleus pada mukosa bukal jauh lebih tinggi dibanding mukosa gingiva.…”

Section: Diskusiunclassified

“…19 Mukosa bukal merupakan sel epitel non keratinisasi sehingga akan lebih menunjukkan efek sitotoksik dan lebih mudah terkena trauma fisik dan kimia jika dibandingkan dengan mukosa gingiva yang merupakan sel epitel keratinisasi. 7 Penelitian Preethi dkk. 13 menyatakan terjadi peningkatan frekuensi mikronukleus yang signifikan pada mukosa bukal akibat paparan radiografi panoramik digital pada anak -anak yang dilakukan perawatan ortodontik.…”

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Perbedaan peningkatan jumlah mikronukleus antara mukosa gingiva dan mukosa bukal akibat paparan radiografi panoramik digital

Olvya

Suryani

Shantiningsih

2019

JRDI

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Objectives: The purpose of this study was to determine the differences in the number of micronuclei between the gingival mucosa and the buccal mucosa due to exposure to digital panoramic radiography. Material and Methods: This study used 10 healthy individuals aged 18-25 years. Exfoliated epithelial cell samples from the gingival and buccal mucosa were taken from the patient on the 10th day after exposure to digital panoramic radiography. The coloring method used is Feulgen-Rossenbeck. Results: The micronucleus calculation was performed by the method of assessing 1000 cells per slide using a binuclear light microscope with a magnification of 400x. The results of the analysis by unpaired T test showed that the difference in the increase in the number of micronuclei was statistically significant (p <0.05). The average difference in the increase in the number of micronuclei was 3.5 ± 0.767. There is a significant difference in the increase in the number of micronuclei between the gingival mucosa and the buccal mucosa due to exposure to digital panoramic radiography with an increase in the number of micronucleus in the buccal mucosa higher than the gingival mucosa. Conclusion: The conclusion of this study is that digital panoramic radiography can cause genotoxic effects on the gingival and buccal mucosa. Digital panoramic radiography is used if needed.

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Effects of low-dose irradiation on human osteoblasts and periodontal ligament cells

Pathomburi

Nalampang

Makeudom

et al. 2020

Archives of Oral Biology

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Genotoxic and cytotoxic biomonitoring in patients exposed to full mouth radiographs – A radiological and cytological study

Cited by 6 publications

References 1 publication

Alteration of mucosa cell maturation pattern after exposure to different radiographic imaging methods

Alteration of mucosa cell maturation pattern after exposure to different radiographic imaging methods

Perbedaan peningkatan jumlah mikronukleus antara mukosa gingiva dan mukosa bukal akibat paparan radiografi panoramik digital

Effects of low-dose irradiation on human osteoblasts and periodontal ligament cells

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