Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in Drosophila melanogaster

Nesterkina, Mariia; Bilokon, Svitlana; Алєксєєва, Т. Г.; Kravchenko, Iryna; Hirsch, Anna K. H.

doi:10.1016/j.toxrep.2023.02.009

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…Thymol has toxic neurological effects and causes neuronal degeneration through direct binding to GABA receptors in Drosophila melanogaster , in addition to showing a highly significant level of repellency towards males and females of D. suzukii (Finetti et al, 2020; Nesterkina et al, 2023).…”

Section: Resultsmentioning

confidence: 99%

“…De Souza et al (2022) Thymol has toxic neurological effects and causes neuronal degeneration through direct binding to GABA receptors in Drosophila melanogaster, in addition to showing a highly significant level of repellency towards males and females of D. suzukii (Finetti et al, 2020;Nesterkina et al, 2023). According to Finetti et al (2020), the biological activity of essential oil constituents is related to functional groups and different modes of action in insects.…”

Section: Antioxidant Potential Of the Essential Oilsmentioning

confidence: 99%

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The antibacterial, antioxidant, and insecticidal activities of essential oils from Thymus vulgaris L., Salvia officinalis L., and Ocimum basilicum L.

Oliveira,

Cardoso,

Batista

et al. 2024

Journal of Food Safety

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The essential oils from Thymus vulgaris, Salvia officinalis, and Ocimum basilicum were extracted by hydrodistillation, characterized by gas chromatography/mass spectrometry, and quantified by gas chromatography/flame ionization detector. The principal constituents were thymol, ρ‐cymene and carvacrol (T. vulgaris); camphor, β‐pinene, and 1,8‐cineole (S. officinalis); and (E)‐anethole, linalool, and 1,8‐cineole (O. basilicum). The essential oil from T. vulgaris was the most effective, forming inhibition halos of 46.16 ± 0.16 and 26.38 ± 0.33 mm, respectively, for Salmonella choleraesuis and Listeria monocytogenes. This essential oil was also more effective against S. choleraesuis, with a minimum inhibitory concentration of 8.85 mg mL−1, and a minimum inhibitory concentration of 17.71 mg mL−1 for L. monocytogenes. No bactericidal activity against S. choleraesuis and L. monocytogenes was observed for the essential oils from S. officinalis, and O. basilicum. Scanning electron micrographs showed that the addition of essential oils left the bacterial cells damaged and deformed. Significant 2,2‐diphenyl‐1‐picrylhydrazyl free radical scavenging capacity and lipid substrate protection were observed in the β‐carotene bleaching assay for the essential oil from T. vulgaris, with IC50 of 231.13 ± 0.53 and 15.25 ± 0.38 μg mL−1, respectively. A dose‐dependent relationship between antioxidant activity and concentrations was observed in the tests. Toxicities of LC50 = 1.24, 3.51 and 1.19 mg mL−1 against Drosophila suzukii flies, respectively, were observed for the essential oils from T. vulgaris, S. officinalis, and O. basilicum. Results suggest that essential oils can be promising antioxidant agents, insecticides, and inhibitors of pathogenic bacteria.

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Section: Resultsmentioning

confidence: 99%