Genotoxic and oxidative damage related to PM<sub>2.5</sub>chemical fraction

Gianotti, Valentina; Scozia, D.; Bonetta, Silvia; Carraro, Elisabetta; Gosetti, Fabio; Oddone, Matteo; Gennaro, Maria Carla

doi:10.2495/air080551

Cited by 1 publication

(1 citation statement)

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“…Similar, results regarding the genetotoxic role of PM 2.5 have been reported previously by Bonetta et al and Ateeq et al thus supporting the findings of the current study. [19][20][21] The GSH concentration was noted to be higher in control groups of both traffic and coal workers as compared to the exposed groups. This low level of GSH in exposed individuals may be attributed to the PM2.5.…”

Section: Discussionmentioning

confidence: 99%

Assessment of DNA damage and oxidative stress among traffic conductors and coal miners

Ullah

Zahid²,

Jawad

et al. 2021

Pak J Med Sci

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Objective: To assess the DNA damage and oxidative stress among traffic conductors and coal miners. Methods: An analytical cross-sectional survey was conducted in Karak, Pakistan from March to October 2019. A total of 240 individuals participated in the study with an age range between 17 to 55 years. Among the total sample, 60 participants had exposure to traffic pollution while 60 were mine workers. Two control groups, consisting of 60 individuals each, were also recruited for comparison with the two exposure groups. Comet assay protocols were performed for assessing DNA damage and oxidative stress (length of DNA tail, levels of Superoxide Dismutase (SOD), Malondialdehyde (MDA) and Glutathione (GSH)). Data was analyzed using T-test on statistix 9.0 software. Results: The DNA tail length in traffic conductors ranged from 26.83-30.55µm (Mean=28.69 µm while their control group had DNA tail length of 7.98-9.26µm (Mean= 8.62). There was significant difference (P <0.001) between exposure and control group. The DNA length recorded in coal mine workers and their control group was ranged from 29.06-31.26µm (Mean=30.16µm) and 9.42-10.22µm (Mean=9.82), respectively. There was significant difference (P <0.001) between the two groups. As compared to control groups, both exposure groups have high levels of Superoxide Dismutase and Malondialdehyde and low levels of Glutathione. The finding was statistically significant (P <0.001). Conclusion: Increased inhalational exposure to air pollutants via working in traffic or coal mines can impose higher oxidative stress and DNA damage among workers as compared to the general population. doi: https://doi.org/10.12669/pjms.37.2.2848 How to cite this:Ullah I, Zahid M, Jawad M, Arsh A. Assessment of DNA damage and oxidative stress among traffic conductors and coal miners. Pak J Med Sci. 2021;37(2):---------. doi: https://doi.org/10.12669/pjms.37.2.2848 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%