Genotoxic assessment of Rubus imperialis (Rosaceae) extract in vivo and its potential chemoprevention against cyclophosphamide-induced DNA damage

Alves, Ana Beatriz Costa Rodrigues; Santos, Rafaella Souza dos; Calil, Susana de Santana; Niero, Rivaldo; Lopes, Jhonny da Silva; Perazzo, Fábio Ferreira; Rosa, Paulo; Andrade, Sérgio Faloni de; Cechinel‐Filho, Valdir; Maistro, Edson Luis

doi:10.1016/j.jep.2014.03.033

Cited by 34 publications

(24 citation statements)

References 20 publications

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“…However, the higher dose of 2000 mg/kg showed statistically significant increase in the MN frequency. Considering this endpoint, our findings for to the two lower doses of Rubus niveus extract are not in accordance with the data obtained in Rubus imperialis extract (Alves et al, 2014). The authors reported that 250 and 500 mg/kg of Rubus imperialis extract caused an increase in the frequency of micronucleated cells.…”

Section: Discussioncontrasting

confidence: 97%

“…These main compounds are similar from that found in other Rubus specie recently investigated by the same scientific viewpoint, Rubus imperialis that showed stigmasterol, niga-ichigoside F1, tormentic acid, 3,3 0 methoxy, 4-O-xylose ellagic acid and 2β, 3β, 19α-trihydroxyursolic acid as a main compounds (Alves et al, 2014).…”

Section: Discussionsupporting

confidence: 87%

“…These results are in agreement with the only study of other species from the genus Rubus available in the literature. Alves et al (2014) reported that Rubus imperialis aerial parts extract also showed no genotoxic effects on leukocytes from peripheral blood or liver cells by the comet assay.…”

Section: Discussionmentioning

confidence: 99%

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In vivo evaluation of the genetic toxicity of Rubus niveus Thunb. (Rosaceae) extract and initial screening of its potential chemoprevention against doxorubicin-induced DNA damage

Tolentino

Araújo

Marques

et al. 2015

Journal of Ethnopharmacology

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Section: Discussioncontrasting

confidence: 97%

Section: Discussionsupporting

confidence: 87%

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In vivo evaluation of the genetic toxicity of Rubus niveus Thunb. (Rosaceae) extract and initial screening of its potential chemoprevention against doxorubicin-induced DNA damage

Tolentino

Araújo

Marques

et al. 2015

Journal of Ethnopharmacology

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“…The number of animals used in these experiments sought to comply with the standards of the Ethics Committee on Animal Use of the Biological Sciences and Health Institute of UFRRJ and to conform to the Principle of the 3R's, besides accompanying the recent references of other authors (Andrade, Perazzo, Maistro, 2008a;Andrade et al, 2008b;Agrawal, Pandely, 2009;Alves et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Laurus nobilis L.: assessment of the cytotoxic and genotoxic potential of aqueous extracts by micronucleus and Allium cepa assays

Silva

Matos

Santos

et al. 2020

Braz. J. Pharm. Sci.

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Laurus nobilis L. is a large shrub belonging to the Lauracea family. Its leaves are widely used for food seasoning as well as in folk medicine. Various studies have demonstrated the antiproliferative, antifungal and antibacterial effects of Laurus nobilis, but no studies have investigated the genotoxic effect of the aqueous extract of the plant. The objective of this study was to analyze the genotoxic potential of an aqueous extract of leaves, using the Allium cepa assay and mouse peripheral blood cell micronucleus test. The results showed that the extract did not have any genotoxic activity, but cytotoxic activity was observed in the two experimental models used. The extract had an antiproliferative effect, detected through the reduction of the mitotic index and the polychromatic/normochromatic erythrocyte (PCE/NCE) ratio. The tests also demonstrated a large number of cells undergoing apoptosis and with nuclear abnormalities related to cell death processes. These results can be explained by the presence of phenolic compounds, saponins, flavonoids and alkaloids, detected in the phytochemical analysis of the extract. Therefore, the extract from L. nobilis in the form generally used by the population does not pose risks related to its genotoxic potential, and also contains components with apoptotic and antigenotoxic potential.

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“…Some studies showed a dose-dependent relationship and even talk about the possible activation of different cellular pathways depending on the tested dose [21, 33]. It has been shown that flavonoids have effects against DNA damage induced by various genotoxic agents, that is, principally by the ability to protect against ROS produced and by the modulation of enzymes responsible for bioactivation and detoxification of genotoxic agents.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Hypoglycemic and Genotoxic Effect of Polyphenolic Bark Extract from Quercus sideroxyla

Soto-García

Rosales-Castro

Escalona-Cardoso

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Quercus sideroxyla is a wood species whose bark has phenolic compound and should be considered to be bioactive; the hypoglycemic and genotoxic properties of Q. sideroxyla bark were evaluated in this study. Total phenolic compound was determined in crude extract (CE) and organic extract (OE). The OE has the highest amount of phenols (724.1 ± 12.0 GAE/g). Besides, both CE and OE demonstrated effect over the inhibition of α-amylase in vitro. Hypoglycemic activity was assessed by glucose tolerance curve and the area under curve (UAC); OE showed the highest hypoglycemic activity. In addition, diabetes was induced by streptozotocin (65 mg/kg) and the extracts (50 mg/kg) were administered for 10 days; OE showed hypoglycemic effect compared with diabetic control and decreased hepatic lipid peroxidation. Acute toxicity and genotoxicity were evaluated in CE; results of acute toxicity did not show any mortality. Besides, the comet assay showed that CE at a dose of 100 mg/kg did not show any genotoxic effect when evaluated at 24 h, whereas it induced slight damage at 200 mg/kg, with the formation of type 1 comets.

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Genotoxic assessment of Rubus imperialis (Rosaceae) extract in vivo and its potential chemoprevention against cyclophosphamide-induced DNA damage

Cited by 34 publications

References 20 publications

In vivo evaluation of the genetic toxicity of Rubus niveus Thunb. (Rosaceae) extract and initial screening of its potential chemoprevention against doxorubicin-induced DNA damage

In vivo evaluation of the genetic toxicity of Rubus niveus Thunb. (Rosaceae) extract and initial screening of its potential chemoprevention against doxorubicin-induced DNA damage

Laurus nobilis L.: assessment of the cytotoxic and genotoxic potential of aqueous extracts by micronucleus and Allium cepa assays

Evaluation of Hypoglycemic and Genotoxic Effect of Polyphenolic Bark Extract from Quercus sideroxyla

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