Genotoxic Effects of Exposure to Gasoline Fumes on Petrol Pump Workers

Shaikh, Amrin; Barot, Darshana; Chandel, Divya

doi:10.15171/ijoem.2018.1159

Cited by 18 publications

(21 citation statements)

References 26 publications

(29 reference statements)

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“…exposed to formaldehyde. 32,36 The present findings observed in buccal cells also typified the cytotoxic effects of cement dust.…”

Section: Discussionsupporting

confidence: 71%

“…Recently, Shaikh, et al, has reported similar effects caused by exposure to gasoline among petrol pump workers. 32 Nuclear changes, other than MN, that represent cellular death, which can enhance the sensitivity of techniques to detect genotoxicity, have been reported by many researchers. [33][34][35] The factors intimately involved in cell growth and death are affected by toxic agents; an increased cell proliferation indicates carcinogenicity.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Genomic Instability in Exfoliated Buccal Cells among Cement Warehouse Workers

Krishna

Sampson

Annamala

et al. 2020

Int J Occup Environ Med

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Background: Workers in cement warehouses of Kerala are enduring long-standing exposure to cement dust, which is considered genotoxic. Objective: To evaluate the extent of genotoxicity and cytotoxicity caused due to exposure of cement dust among those working in cement warehouses. Methods: The study included 82 cement warehouse workers and 82 age-matched individuals with no exposure to cement dust. Exfoliated buccal micronucleus cytome assay (BMCyt) was performed to analyze the genotoxic and cytotoxic effects caused by inhalation of cement dust. Results: The frequency of various genotoxic and cytotoxic end markers (micronucleated cells [2-fold increase, p<0.001], nuclear buds [4-fold increase, p<0.001], binucleated cells [4-fold increase, p<0.001], karyorrhectic cells [2-fold increase, p<0.001], pyknotic cells [3- fold increase, p<0.001], and karyolytic cells [2-fold increase, p<0.001]) were higher in the exposed workers compared with unexposed group. Increase of these parameters represented an increased level of chromosomal damage, nuclear disintegration and increased cell death among exposed group compared with unexposed group. Conclusion: Continuous exposure to cement dust results in increased frequency of nuclear aberrations and cellular apoptosis. This may lead to defects in genome maintenance, accelerated ageing, increased chance of oral cancer and neurodegenerative disorders in those occupationally exposed to cement dust.

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“…exposed to formaldehyde. 32,36 The present findings observed in buccal cells also typified the cytotoxic effects of cement dust.…”

Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Genomic Instability in Exfoliated Buccal Cells among Cement Warehouse Workers

Krishna

Sampson

Annamala

et al. 2020

Int J Occup Environ Med

View full text Add to dashboard Cite

show abstract

“…В последние годы для прогнозирования риска развития рака у лиц, связанных с влиянием на организм длительно существующих вредных привычек (курение, алкогольная зависимость), с действием факторов внешней среды, про-фессионального вреда широко используется цитогенетическая характеристика ядер соматических немалигнизированных клеток -образование МЯ вследствие повреждения ДНК, гибель клеток, пикноз, кариолиз и кариорексис [25][26][27][28][29][30][31][32].…”

Section: цитогенетические цитотоксические эффекты и изменения молекуunclassified

Современное Развитие Направления — Цитологическая Реактивность Больного Онкологического Профиля

2020

clinicaloncology

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“…Apart from the skin, and respiratory lesions, a high risk of cancer caused by benzene, cytotoxicity and genotoxicity affecting the integrity of DNA in petrol station workers have been reported [33][34][35][36][37]. The consequences of petrol on the health of vendors vary depending on the length of exposure and become more dangerous for those who have spent several years in this business [38].…”

Section: Health Related Consequences Due To Exposure To Petrolmentioning

confidence: 99%

The Counterfeit Petrol Business in Benin and Associated Health Consequences Among Stakeholders

Mamatou¹,

Gbaguidi²,

Ignace³

et al. 2020

CAJPH

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In Benin counterfeit fuel is sold across the country, but the health consequences associated with this activity are not documented. The present study was conducted to describe the specificities of this business in a representative municipality of Southern Benin and to identify its health-related consequences as perceived by the vendors. Data was collected using a questionnaire survey in 160 vendors of counterfeit petrol in the municipality of Abomey-Calavi. The data were analyzed with SAS software and the proportions were compared two by two with the two-tailed Z test. The findings reveal that the trade of counterfeit petrol involves as many men (53%) as women (47%). The vendors have an average of 10.14 years of experience in the business. The conditions for practicing the profession are not optimal. Vendors store their fuel at the point of sale and they work more than 8 hours a day. Most of the respondents sold petrol at less than 400 F CFA (97.47%). At this price, most of them (51.27%) made a daily profit between 1000 and 5000 F CFA per day. Despite this daily profit, most of the respondents (73.20%) wish to change their profession because of the perceived health hazards that can be caused by prolonged exposure to petrol. Most vendors said to experience fatigue (82.76%), headache (66.21%), dizziness (60.69%) and skin irritations (51.03%). Moreover, respiratory symptoms were reported by the respondents including mainly sneezing (69.92%), stuffed nose (68.42%), loss of smell (55.64%), episodes of rhinorrhea (53.38%) and throat irritations (51.88%). The proportions of people reporting sneezing and stuffy nose were significantly higher (p<0.05) than in the other categories. Despite these health risks, very few of them seek medical care when ill. A spatial distribution of vendors based on symptoms generated three main categories. The 1st group is composed of vendors from Glo-Djibé, Hèvié and Kpanroun. Those of group 2 are located in Akassato and Zinvié; while vendors from Godomey, Calavi, Togba and Ouédo made the last group. Frequently reported symptoms were dizziness, irritation of the eyes and loss of smell in the 1st group; episodes of rhinorrhea and irritation of the throat in group 2. Most symptoms reported in group 3 were headache, fatigue, lower back pain, stuffy nose and dental problems. Although the counterfeit petrol business generates interesting profits to traders, the associated hazards are enormous, hence the need to improve the technical and safety conditions of this sector.

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Genotoxic Effects of Exposure to Gasoline Fumes on Petrol Pump Workers

Abstract: Background: Petrol pump workers are occupationally exposed to gasoline and its fumes

Cited by 18 publications

References 26 publications

Genomic Instability in Exfoliated Buccal Cells among Cement Warehouse Workers

Genomic Instability in Exfoliated Buccal Cells among Cement Warehouse Workers

Современное Развитие Направления — Цитологическая Реактивность Больного Онкологического Профиля

The Counterfeit Petrol Business in Benin and Associated Health Consequences Among Stakeholders

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