Genotoxic effects of gadobutrol and gadoversetamide active substances used in magnetic resonance imaging in human peripheral lymphocytes<i>in vitro</i>

Akbas, Ece; Ünal, Fatma; Yüzbaşıoğlu, Deniz

doi:10.1080/01480545.2021.1957913

Cited by 3 publications

(7 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The comet assay results indicate that gadobutrol has a weak genotoxic effect on isolated lymphocytes (Akbas ¸et al, 2022).…”

Section: Genotoxic Effects Of Contrast Agentsmentioning

confidence: 96%

Section: Cytotoxic Effects Of Contrast Agentsmentioning

confidence: 99%

“…Mitotic index (MI) is a reproducible and sensitive parameter of cell proliferation, cytotoxicity, and cytostasis (Akbas ¸et al, 2022;Chac on et al, 2021). In a recent study, the cytotoxic effects of gadobutrol and gadoversetamide were determined by MI in human peripheral lymphocytes with the same concentrations of 7000-112,000 μg/ml (Akbas ¸et al, 2022). Both of the contrast agents resulted in decreased MI which was statistically significant at the two highest concentrations, but the decrease generated by gadoversetamide was more prominent.…”

Section: Cytotoxic Effects Of Contrast Agentsmentioning

confidence: 99%

“…The genotoxicity of chemicals can also be determined by the sister chromatid exchanges (SCEs) assay which is a simple and rapid method that indicates the genetic material exchange at homologous loci during the S phase of the cell cycle (Akbaş et al, 2022; Avuloglu‐Yilmaz et al, 2022; Yilmaz et al, 2015). SCE formation is associated with the recombinational repair, as well as point mutations, gene amplifications, and cytotoxicity (Cobanoglu & Cayir, 2021).…”

Section: Genotoxicity Testsmentioning

confidence: 99%

“…In a recent study, in vitro genotoxic effects of the same concentrations of gadobutrol and gadoversetamide were examined on human lymphocytes by CAs, SCEs, and MN tests, also comet assay for gadobutrol (Akbas et al, 2022) (Table 1). Human peripheral lymphocytes (HPLs) were treated with 7000, 14,000, 28,000, 56,000, and 112,000 μg/ml of both agents.…”

Section: Genotoxicity Testsmentioning

confidence: 99%

See 4 more Smart Citations

Cellular toxicities of gadolinium‐based contrast agents used in magnetic resonance imaging

Akbas

Ünal

Yüzbaşıoğlu

2022

J of Applied Toxicology

Self Cite

View full text Add to dashboard Cite

Contrast agents have been used in magnetic resonance imaging (MRI) as a radiological method. Gadolinium‐based contrast agents (GBCAs), because of their paramagnetic characteristics, are the ones mostly used in MRI to increase signal intensity. However, the use of contrast media has raised concerns on cellular toxic risks of these agents. Studies showed the accumulation of gadolinium after injection to humans with or without renal impairment. Also, there are findings obtained under in vitro and/or in vivo conditions that revealed conflicting results for their cytotoxic and genotoxic effects. Some of them declared damage in cells and genetic material; some others did not. Abnormal cell growth and genetic aberration are critical because they may lead to carcinogenesis in somatic cells or may be transferred to the next generations through germ cells. Therefore, understanding the effect of GBCAs on cells is important for their safer usage in clinical administrations to generate high‐quality contrast‐enhanced magnetic resonance images. Because of all these reasons, cellular toxicities—mainly genotoxic and cytotoxic effects—of GBCAs were reviewed in this paper.

show abstract

“…The comet assay results indicate that gadobutrol has a weak genotoxic effect on isolated lymphocytes (Akbas ¸et al, 2022).…”

Section: Genotoxic Effects Of Contrast Agentsmentioning

confidence: 96%

Section: Cytotoxic Effects Of Contrast Agentsmentioning

confidence: 99%

Section: Cytotoxic Effects Of Contrast Agentsmentioning

confidence: 99%

Section: Genotoxicity Testsmentioning

confidence: 99%

Section: Genotoxicity Testsmentioning

confidence: 99%

See 3 more Smart Citations

Cellular toxicities of gadolinium‐based contrast agents used in magnetic resonance imaging

Akbas

Ünal

Yüzbaşıoğlu

2022

J of Applied Toxicology

Self Cite

View full text Add to dashboard Cite

show abstract

Comparative investigation of iron oxide nanoparticles and microparticles using the in vitro bacterial reverse mutation and in vivo Allium chromosome aberration and comet assays

Kizilkaya,

Unal,

Beyzi

et al. 2023

J Nanopart Res

View full text Add to dashboard Cite

Genotoxic and Cytotoxic Effects of Nanoparticle and Bulk Forms of Molybdenum Trioxide and Molybdenum Disulfide Used in Bioimaging and Cancer Therapy

Korkmaz,

Ünal,

Akbaş

et al. 2024

Black Sea Journal of Engineering and Science

View full text Add to dashboard Cite

Nanoparticles (NPs) and bulk forms of MoO3 and MoS2 (0.1, 1, 10 and 100 µg/mL) used in cancer treatment and bioimaging were investigated by chromosome aberration, CBMN-Cyt and comet assay in human lymphocytes for the first time. This study compared both MoO3 and MoS2 and their NPs (two-dimensional (2D)) and bulk forms. Both NP and bulk forms of MoO3 and MoS2 did not cause an increase in abnormal cell frequency and CA/Cell compared to the control. While both NPs and bulk forms of MoS2 significantly increased the micronucleus frequency, MoO3 did not cause an increase. This increase was slightly higher in MoS2 NPs than in their bulk form. According to our comet assay results, both NPs and bulk forms of the MoO3 and MoS2 significantly increased the DNA damage at all concentrations. Both MoO3 and MoS2 significantly decreased MI. Neither MoO3 nor MoS2 caused a significant variation in NDI, CBPI, % cytostasis, NPB, and NBUD frequency compared to the negative control. Both particles were also characterized physicochemically. Our results revealed that MoO3 and MoS2 may have weak genotoxic and cytotoxic effects. Therefore, the toxicity potential of these particles and their underlying mechanisms for safer usage need to be investigated in more detail by other in vivo and in vitro genotoxicity and cytotoxicity tests.

show abstract

Genotoxic effects of gadobutrol and gadoversetamide active substances used in magnetic resonance imaging in human peripheral lymphocytesin vitro

Cited by 3 publications

References 85 publications

Cellular toxicities of gadolinium‐based contrast agents used in magnetic resonance imaging

Cellular toxicities of gadolinium‐based contrast agents used in magnetic resonance imaging

Comparative investigation of iron oxide nanoparticles and microparticles using the in vitro bacterial reverse mutation and in vivo Allium chromosome aberration and comet assays

Genotoxic and Cytotoxic Effects of Nanoparticle and Bulk Forms of Molybdenum Trioxide and Molybdenum Disulfide Used in Bioimaging and Cancer Therapy

Contact Info

Product

Resources

About