Genotoxic potentiality of aqueous extract prepared from Chrysobalanus icaco L. leaves

Ferreira-Machado, Samara Cristina; Rodrigues, M. P.; Nunes, A.P.M.; Dantas, F. J. S.; Mattos, Julio Cezar Paz de; Silva, C.R; Moura, Egberto Gaspar de; Bezerra, Roberto J.A.C.; Caldeira-de-Araújo, Adriano

doi:10.1016/j.toxlet.2004.03.014

Cited by 51 publications

(40 citation statements)

References 21 publications

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“…Herbal medicines can be potentially toxic to human health. In this way, scientific research has shown that many plants used in traditional and folk medicine are potentially toxic, mutagenic, and carcinogenic (Mengs, 1988., Ferreira-Machado et al, 2004.…”

Section: Toxicity Risk Of Plant Extractmentioning

confidence: 99%

Potential Genotoxic and Cytotoxic Effects of Plant Extracts

Çelik¹

2012

A Compendium of Essays on Alternative Therapy

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Section: Toxicity Risk Of Plant Extractmentioning

confidence: 99%

Potential Genotoxic and Cytotoxic Effects of Plant Extracts

Çelik¹

2012

A Compendium of Essays on Alternative Therapy

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“…This interaction may result in either DNA damage or induce genotoxic/ mutagenic insults. Studies evaluating the genotoxicity of plants using plasmid DNA have been used as an in vitro model to establish the safety of medicinal plants (de Carvalho et al, 2003;Ferreira-Machado et al, 2004). The in vitro cell-free DNA test will determine DNA strand breaks resulting from the interaction of genotoxic/ mutagenic substances with DNA.…”

mentioning

confidence: 99%

Antiparkinson drug – Mucuna pruriens shows antioxidant and metal chelating activity

Dhanasekaran¹,

Tharakan

Manyam

2007

Phytotherapy Research

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Parkinson's disease is a neurodegenerative disorder for which no neurorestorative therapeutic treatment is currently available. Oxidative stress plays an important role in the pathophysiology of Parkinson's disease. The ancient Indian medical system, Ayurveda, traditionally uses Mucuna pruriens to treat Parkinson's disease. In our earlier studies, Mucuna pruriens has been shown to possess antiparkinson and neuroprotective effects in animal models of Parkinson's disease. The antioxidant activity of Mucuna pruriens was demonstrated by its ability to scavenge DPPH radicals, ABTS radicals and reactive oxygen species. Mucuna pruriens significantly inhibited the oxidation of lipids and deoxyribose sugar. Mucuna pruriens exhibited divalent iron chelating activity and did not show any genotoxic/mutagenic effect on the plasmid DNA. These results suggest that the neuroprotective and neurorestorative effect of Mucuna pruriens may be related to its antioxidant activity independent of the symptomatic effect. In addition, the drug appears to be therapeutically safe in the treatment of patients with Parkinson's disease.

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“…On the other hand, no antigenotoxic effect was shown for root extracts. This experimental approach has been used elsewhere in order to evaluate a genotoxic or antigenotoxic profile induced by different plant species (Biso et al, 2010;Ferreira-Machado et al, 2004;Hamedt et al, 2014). Therefore, the use of other study designs, both in vivo and in vitro, is necessary to ensure the safety and efficacy of S. brasiliensis as a medicinal plant.…”

Section: Resultsmentioning

confidence: 99%

Assessment of the genotoxic and antigenotoxic potential of crude extracts and fractions of Schwartzia brasiliensis (Choisy) Bedell ex Giraldo-Caas

S¹,

Mattos²,

F³

et al. 2015

J. Med. Plants Res.

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Schwartzia brasiliensis (Marcgraviaceae) is a native Brazilian shrub species with neotropical distribution in shoal environments. Recent studies have revealed its medicinal potential for some human diseases; therefore, this study aimed to evaluate the genotoxic and antigenotoxic potential of extracts and fractions obtained from different organs of S. brasiliensis. To accomplish this, plant extracts at different concentrations (25, 125 and 250 µg/ml) were incubated with plasmid DNA, either alone, or in the presence of stannous chloride as a positive control. Samples were then examined to detect any plasmid strand breaks or the absence of such breaks, which would indicate protection of these molecules against stannous chloride-induced lesions. Methanol and aqueous extracts of leaves and stems showed the ability to withstand the effects of stannous chloride in that no DNA damage was observed. Moreover, no other extracts or fractions used in the experimental conditions assayed resulted in DNA damage. These findings suggest that S. brasiliensis has antigenotoxic properties, indicating, in turn, that its biological activities deserve further study given the medicinal relevance of this plant.

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Genotoxic potentiality of aqueous extract prepared from Chrysobalanus icaco L. leaves

Cited by 51 publications

References 21 publications

Potential Genotoxic and Cytotoxic Effects of Plant Extracts

Potential Genotoxic and Cytotoxic Effects of Plant Extracts

Antiparkinson drug – Mucuna pruriens shows antioxidant and metal chelating activity

Assessment of the genotoxic and antigenotoxic potential of crude extracts and fractions of Schwartzia brasiliensis (Choisy) Bedell ex Giraldo-Caas

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