Genotoxicity and carcinogenicity of metronidazole

Spectroscopic and Molecular Docking Studies on the Interaction of Dimetridazole With Human Serum Albumin

“…It has also been used for the treatment of genital trichomoniasis in cattle and haemorrhagic enteritis in pigs. The use of DMZ in veterinary practice is strictly regulated in many countries because of DMZ and its metabolites are suspected of being human carcinogens and mutagens [2][3][4][5] . However, the chemical-grade powder of DMZ is available and many pharmacies can compound the drug into tablets or capsules 6,7 .…”

Teratogenic evaluation of metronidazole and ornidazole using Drosophila melanogaster as an experimental model

“…Imidazole derivatives are widely used in human and animal therapy, as well as in fungicides in plants; therefore, it is important to characterize any possible undesired effects in different experimental models. In particular, the nitrogen group present in nitroimidazole derivatives is considered responsible for the mutagenicity of these compounds (Dobiáš et al, 1994). Our previous work at different levels of complexity (from cell to tissue) supported a new characterization of these compounds at the organism level.…”

“…Although different short‐term tests have been applied to characterize the genotoxicity of nitroimidazole effects in different animal or human systems, data on the teratology or developmental toxicology of these compounds derivatives are scarce (Piper et al, 1993; Dobiáš et al, 1994; Mudry et al, 2001). As mentioned previously, Drosophila melanogaster has been proposed as a model system for screening developmental toxicity of xenobiotics; thus the present study aimed to provide new data on the effect of two 5‐nitroimidazoles, metronidazole (MTZ) [1‐(2‐hydroxyethyl)‐2‐methyl‐5‐nitroimidazole] and ornidazole (ONZ) [1‐(3‐chloro‐2‐hydroxy)propyl‐2‐methyl‐5‐nitroimidazole] on the developmental stages of D. melanogaster from the egg through the three larval stages to the pupa.…”

Synthetic Nitroimidazoles: Biological Activities and Mutagenicity Relationships

“…In this study, the methyl group at the 2-position combined with the arylsulfonylmethyl group at the 4-position lowered the MP TA100 of dimetridazole, metronidazole and secnidazole series [47]. A good correlation was demonstrated between the antiprotozoal activity and the mutagenicity for these molecules which reflects their ability to damage DNA through covalent binding and induction of DNA breaks [51]. They were characterized by a low mutagenicity and high antiparasitic activity.…”