Genotoxicity and maternal-fetal safety of the dried extract of leaves of Azadirachta indica A. Juss (Meliaceae) in Wistar rats

Ramalho, Carlos Eduardo Lacerda; Reis, Diego dos Santos; Caixeta, Graziele Alícia Batista; Oliveira, Micaelle Cristina de; Silva, Danielle Milany Fernandes da; Cruvinel, Wilson de Melo; Teófilo, Monatha Nayara Guimarães; Gomes, Clayson Moura; Sousa, Priscilla Abdala de; Soares, Leiza Fagundes; Melo, Anielly Monteiro de; Rocha, Jamira Dias; Bailão, Elisa Flávia Luiz Cardoso; Amaral, Vanessa Cristiane Santana; Paula, Joelma Abadia Marciano de

doi:10.1016/j.jep.2023.116403

Journal of Ethnopharmacology

2023

DOI: 10.1016/j.jep.2023.116403

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Genotoxicity and maternal-fetal safety of the dried extract of leaves of Azadirachta indica A. Juss (Meliaceae) in Wistar rats

Carlos Eduardo Lacerda Ramalho

Diego dos Santos Reis

Graziele Alícia Batista Caixeta

et al.

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2024

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Cited by 2 publications

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Genotoxic and antigenotoxic medicinal plant extracts and their main phytochemicals: “A review”

Al-Naqeb,

Kalmpourtzidou,

Giampieri

et al. 2024

Front. Pharmacol.

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Many medicinal plant extracts have been proven to have significant health benefits. In contrast, research has shown that some medicinal plant extracts can be toxic, genotoxic, mutagenic, or carcinogenic. Therefore, evaluation of the genotoxicity effects of plant extracts that are used as traditional medicine is essential to ensure they are safe for use and in the search for new medication. This review summarizes 52 published studies on the genotoxicity of 28 plant extracts used in traditional medicine. A brief overview of the selected plant extracts, including, for example, their medicinal uses, pharmacological effects, and primary identified compounds, as well as plant parts used, the extraction method, genotoxic assay, and phytochemicals responsible for genotoxicity effect were provided. The genotoxicity effect of selected plant extracts in most of the reviewed articles was based on the experimental conditions. Among different reviewed studies, A total of 6 plant extracts showed no genotoxic effect, other 14 plant extracts showed either genotoxic or mutagenic effect and 14 plant extracts showed anti-genotoxic effect against different genotoxic induced agents. In addition, 4 plant extracts showed both genotoxic and non-genotoxic effects and 6 plant extracts showed both genotoxic and antigenotoxic effects. While some suggestions on the responsible compounds of the genotoxicity effects were proposed, the proposed responsible phytochemicals were not individually tested for the genotoxicity potential to confirm the findings. In addition, the mechanisms by which most plant extracts exert their genotoxicity effect remain unidentified. Therefore, more research on the genotoxicity of medicinal plant extracts and their genotoxicity mechanisms is required.

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Genotoxic and antigenotoxic medicinal plant extracts and their main phytochemicals: “A review”

Al-Naqeb,

Kalmpourtzidou,

Giampieri

et al. 2024

Front. Pharmacol.

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Influência da administração oral do extrato etanólico das folhas de Nim (Azadirachta indica A. juss) em ratas Wistar durante o terço final da gestação

Silva,

Chagas

et al. 2024

Cad. Pedagógico

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O objetivo foi avaliar a influência da administração oral do extrato etanólico das folhas de Neem (Azadirachta indica A. juss) em ratas Wistar durante o terço inicial da gestação. Foram utilizadas 16 ratas Wistar, distribuídas aleatoriamente em grupo controle e três grupos experimentais tratados no 4º, 5º e 6º dias de gestação, nas doses de 65, 135 e 200mg/kg respectivamente. Foram coletados, no 9º dia de gestação após eutanásia, fragmentos de útero, ovários e embriões, os quais foram fixados em formalina tamponada a 10%. Não houve diferenças estatísticas em relação ao ganho de massa corporal dos animais prenhes durante os primeiros nove dias de gestação. Não houve diferenças estatísticas quanto ao peso dos ovários, à quantidade e à massa corporal dos embriões implantados. Quanto à morfologia, foram encontrados resultados diferentes nos grupos controle e experimental, porém não foram observadas alterações patológicas que pudessem ser causadas pela administração do Neem. Na avaliação macroscópica uterina observou-se ausência de reabsorções e presença de implantação embrionária. Na microscopia ovariana foram observados folículos em diferentes estágios de desenvolvimento, corpos lúteos, células intersticiais, infiltrado inflamatório e vasos congestionados na região medular. Na avaliação uterina foram encontrados infiltrados subepiteliais, atrofia das glândulas endometriais, endométrio e miométrio com grande quantidade de colágeno, além de endométrio não reagente. Conclui-se que a administração do extrato etanólico de folhas de Neem nas doses de 65, 135 e 200mg/kg durante a gestação não reduziu a fertilidade, não causou alterações macroscópicas ou microscópicas ovarianas ou uterinas, demonstrando segurança para uso em ratas nas doses avaliadas.

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Genotoxicity and maternal-fetal safety of the dried extract of leaves of Azadirachta indica A. Juss (Meliaceae) in Wistar rats

Cited by 2 publications

References 58 publications

Genotoxic and antigenotoxic medicinal plant extracts and their main phytochemicals: “A review”

Genotoxic and antigenotoxic medicinal plant extracts and their main phytochemicals: “A review”

Influência da administração oral do extrato etanólico das folhas de Nim (Azadirachta indica A. juss) em ratas Wistar durante o terço final da gestação

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