Genotoxicity and mutagenicity of particulate matter emitted from diesel, gas to liquid, biodiesel, and farnesane fuels: A toxicological risk assessment

Soriano, José A.; García-Contreras, Reyes; Fuente, José de la; Orozco-Jiménez, Luz Y.; Agudelo, John R.

doi:10.1016/j.fuel.2020.118763

Cited by 19 publications

(10 citation statements)

References 40 publications

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“…Comparing organic solvents, DCM is generally applied to extract PAHs (Masood et al, 2018 ). It was also used in the study of Soriano et al ( 2020 ) to assess genotoxic and mutagenic potential of soluble organic material extracted from PM emission of a diesel engine run on different alternative and/or renewable fuels and in the study of Morakinyo et al ( 2020 ) to evaluate carcinogenic and mutagenic risks of PM2.5-bound PAHs. Jing et al ( 2019 ) measured the residual toxicity of eight common extraction solvents in a study evaluating PM2.5 related biotoxicity in Shanghai.…”

Section: Resultsmentioning

confidence: 99%

Ecotoxicity testing of airborne particulate matter—comparison of sample preparation techniques for the Vibrio fischeri assay

Kováts

Hubai

Sainnokhoi

et al. 2021

Environ Geochem Health

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The bioassay based on the bioluminescence inhibition of the marine bacterium Vibrio fischeri has been the most widely used test for the assessment of airborne particulate matter ecotoxicity. Most studies available use an extract of the solid sample, either made with water or organic solvents. As an alternative, a whole-aerosol test is also available where test bacteria are in actual contact with contaminated particles. In our study, different extraction procedures were compared to this direct contact test based on the V. fischeri assay and analytical measurements. The lowest PAH content and the highest EC50 were determined in water extract, while the highest PAH amount and lowest EC50 were measured in dichloromethane, hexane, and dimethyl-sulphoxide extracts. EC50 of the direct contact test was comparable to that of the methanol extract. Our results suggest that the sensitivity of the direct contact test equals to that of extraction procedures using organic solvents, moreover, it is mimicking an environmentally realistic exposure route.

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Section: Resultsmentioning

confidence: 99%

Ecotoxicity testing of airborne particulate matter—comparison of sample preparation techniques for the Vibrio fischeri assay

Kováts

Hubai

Sainnokhoi

et al. 2021

Environ Geochem Health

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“…The imbalance between the production and elimination of ROS causes oxidative stress, which has been associated with aging, carcinogenesis, and Alzheimer’s disease [ 45 , 46 ]. Genotoxicity testing is important to provide adequate hazard identification and risk assessment in terms of the carcinogenesis process [ 47 ]. It is well known that fine particle fraction including DEP induces genotoxicity for two main biological processes: ROS production and increased damage in the cell.…”

Section: Discussionmentioning

confidence: 99%

Determination of Genotoxicity Attributed to Diesel Exhaust Particles in Normal Human Embryonic Lung Cell (WI-38) Line

Lee

Lim

et al. 2021

Biomolecules

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Several epidemiological studies concluded that inhalation of diesel exhaust particles (DEP) is associated with an increase in the relative risk of lung cancer. In vitro research evaluating the genetic damage and/or changes in gene expression have been attempted to explain the relationship between DEP exposure and carcinogenicity. However, to date, investigations have been largely confined to studies in immortalized or tumorigenic epithelial cell models. Few studies have investigated damage at the chromosomal level to DEP exposure in normal cell lines. Here, we present the genotoxic effects of DEP in normal cells (embryonic human lung fibroblasts) by conventional genotoxicity testing (micronuclei (MN) and comet assay). We show the differentially expressed genes and enriched pathways in DEP-exposed WI-38 cells using RNA sequencing data. We observed a significant increase in single-strand DNA breaks and the frequency of MN in DEP-exposed cells in a dose-dependent manner. The differentially expressed genes following DEP exposure were significantly enriched in the pathway for responding to xenobiotics and DNA damage. Taken together, these results show that DEP exposure induced DNA damage at the chromosomal level in normal human lung cells and provide information on the expression of genes associated with genotoxic stress.

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“…Combustibles líquidos (Agudelo et al, 2011;Baldrich & Novoa, 2006;Benjumea et al, 2008;Cacua et al, 2011b;Zuleta et al, 2012) y sólidos(É. Arenas & Chejne, 2004;Blandon et al, 2008;Díez & Pérez, 2017;Jiménez et al, 2012;Orrego et al, 2010;Orrego-Ruiz et al, 2011;Reyes et al, 2003) Fracciones de petróleo (Baldrich Ferrer & Novoa Mantilla, 2007;León et al, 2020;Morantes et al, 2019;Poveda-Jaramillo et al, 2016;Villabona-Estupiñan et al, 2020) Productos de la combustión (Arias et al, 2021;Ávila et al, 2021;Botero et al, 2020Botero et al, , 2021Cadrazco et al, 2019Cadrazco et al, , 2020Johnson-Restrepo et al, 2008;Mendoza et al, 2021;Oliveira et al, 2019;Parga-Lozano et al, 2002;Soriano et al, 2020) Propiedades claves de combustibles como velocidad de llama laminar, las dimensiones y temperatura de la llama, el índice Wobbe, los calores inferiores y superiores de combustión, los límites de inflamabilidad y el punto de rocío (Álvarez et al, 2019;Burbano et al, 2011aBurbano et al, , 2011bCacua et al, 2011b;Y. Cadavid & Amell, 2019;Cala et al, 2013;Cardona Medina et al, 2013;Cardona-Vargas et al, 2020;Cardona Vargas & Amell-Arrieta Andrés Adolfo Arrieta Carlos, 2016;…”

Section: Koreaunclassified

Hacia una estructura de investigación y educación para la prevención de accidentes por incendios y explosiones en Colombianción de accidentes por incendios y explosiones en Colombia

Molina

López

Escobar

et al. 2021

Rev. Acad. Colomb. Cienc. Ex. Fis. Nat.

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Se analizó la situación actual de la investigación y la educación en incendios y explosiones en Colombia desde un enfoque de ciencia e ingeniería y se hicieron recomendaciones sobre los campos que deben desarrollarse para crear una estructura investigativa y educativa que respalde los esfuerzos por prevenirlos. Dado el riesgo de incendios y explosiones, la mayoría de los países han propiciado la creación de centros de investigación y educación orientados al desarrollo científico en esta área. En Colombia tal infraestructura tiene un desarrollo apenas incipiente. La revisión de aspectos importantes en incendios y explosiones como el análisis estadístico, la caracterización fisicoquímica de sustancias inflamables, la cinética química, la combustión, la simulación, la radiación térmica, los fenómenos de pirólisis, el smouldering, la formación de hollín y de humo, la caracterización experimental, la evaluación de riesgos, la educación y otros aspectos específicos de las explosiones evidenció que en Colombia existe un buen desarrollo en la aplicación de la combustión y la pirólisis con fines comerciales, pero sin énfasis en incendios y explosiones. En las demás áreas existen antecedentes de investigación específicamente relacionados con este campo que deben reforzarse. Se recomienda la creación de programas curriculares de posgrado en ciencia y tecnología en esta área, así como el aumento de la capacidad experimental para la caracterización de sustancias inflamables, el fortalecimiento de la investigación en ciencias básicas y el desarrollo de habilidades de computación y simulación.

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Genotoxicity and mutagenicity of particulate matter emitted from diesel, gas to liquid, biodiesel, and farnesane fuels: A toxicological risk assessment

Cited by 19 publications

References 40 publications

Ecotoxicity testing of airborne particulate matter—comparison of sample preparation techniques for the Vibrio fischeri assay

Ecotoxicity testing of airborne particulate matter—comparison of sample preparation techniques for the Vibrio fischeri assay

Determination of Genotoxicity Attributed to Diesel Exhaust Particles in Normal Human Embryonic Lung Cell (WI-38) Line

Hacia una estructura de investigación y educación para la prevención de accidentes por incendios y explosiones en Colombianción de accidentes por incendios y explosiones en Colombia

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