Genotoxicity and teratogenicity of seabuckthorn (<i>Hippophae rhamnoides</i> L.) berry oil

Wen, Pingjing; Zhao, Peng; Qin, Guangqiu; Tang, Song; Li, Bin; Zhang, Jiehong; Peng, Liang

doi:10.1080/01480545.2018.1497047

Cited by 26 publications

(19 citation statements)

References 23 publications

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“…Acute and sub-chronic toxicity studies performed in Wistar rats have shown no signs of toxicity and reported a no-observed-adverse-effect level of 10 ml/kg body weight (Zhao et al, 2017). Furthermore, no mutagenicity was observed from the SBKT exposure in histidine-dependent Salmonella typhimurium stain (Wen et al, 2018), suggesting no induction of genotoxicity by SBKT. Exposure to SBKT also did not induce any changes in sperm morphology and micronucleus formation rate in polychromatic erythrocytes obtained from mice orally treated with the oil (Wen et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, no mutagenicity was observed from the SBKT exposure in histidine-dependent Salmonella typhimurium stain (Wen et al, 2018), suggesting no induction of genotoxicity by SBKT. Exposure to SBKT also did not induce any changes in sperm morphology and micronucleus formation rate in polychromatic erythrocytes obtained from mice orally treated with the oil (Wen et al, 2018). In the present study, we have not seen any change in the animal weights, food, or water consumption (data not shown).…”

Section: Discussionmentioning

confidence: 99%

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Cytokines Driven Anti-Inflammatory and Anti-Psoriasis Like Efficacies of Nutraceutical Sea Buckthorn (Hippophae rhamnoides) Oil

et al. 2019

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Psoriasis is a chronic inflammatory skin disease characterized by circumscribed, red, thickened plaques with overlying silvery white scales. It is associated with the release of pro-inflammatory mediators that lead to the development of edema and distress. Here we show the anti-inflammatory and anti-psoriatic efficacies of a neutraceutical sea buckthorn oil (SBKT) derived from the fruit pulp of Hippophae rhamnoides. Chemical analysis of the SBKT showed the presence of 16 major saturated, mono-, and polyunsaturated fatty acids components, imparting significant nutritional values. Efficacy of the SBKT in modulating psoriasis and associated inflammation was first tested in vitro using human monocytic (THP-1) cells. SBKT induced cytotoxicity at a dose of ≥25 µl/ml. Treatment of the lipopolysaccharide-stimulated THP-1 cells with SBKT subdued the enhanced release of intracellular reactive nitrogen species and expression of NF-κB protein, in a concentration-dependent manner. This was accompanied by a reduction in the release of downstream pro-inflammatory cytokines: Interleukin-1ß and interleukin-6. Tumor necrosis factor-α released in the stimulated THP-1 cells were also inhibited by SBKT dose of 5 µl/ml. In vivo oral and topical treatment with SBKT in the Carrageenan-stimulated paw edema model, showed a significant decrease in paw volume and edema. In the 12-O tetradecanoyl phorbol 13-acetate (TPA) stimulated CD-1 mice psoriasis-like model, concurrent oral and tropical SBKT treatments substantially reduced ear edema and ear biopsy weights. Histopathologically, significant reduction in ear epidermal thickness and skin lesion scores was observed in the SBKT-treated animals. In conclusion, SBKT showed anti-inflammatory and anti-psoriasis-like efficacies in healing chemical-induced inflammation and psoriasis. The possible mode of action of SBKT was found through inhibition of reactive nitrogen species, and downregulation of NF-κB protein and pro-inflammatory cytokines. Thus, the present data suggest that Sea buckthorn oil can be used as an anti-inflammatory and anti-psoriatic nutraceutical.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cytokines Driven Anti-Inflammatory and Anti-Psoriasis Like Efficacies of Nutraceutical Sea Buckthorn (Hippophae rhamnoides) Oil

et al. 2019

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“…However, data regarding to the cytotoxicity and genotoxicity of the seabuckthorn and its extracts are still scarce. Efforts have been spent to explore the pharmacological activities while only a few studies have focused on the safety evaluation of the plant extracts [59,60]. In a study on mice, the maximum tolerated dose of seabuckthorn oil was >20 mL/kg for mice in relation to acute toxicity, and the no-observed-adverse-effect level was of 10 mL/kg body weight in both male and female rats regarding the 90-day toxicity study [61].…”

Section: Discussionmentioning

confidence: 99%

Cytogenetic Study on the Biostimulation Potential of the Aqueous Fruit Extract of Hippophae rhamnoides for a Sustainable Agricultural Ecosystem

Bonciu

Olaru

Roșculete

et al. 2020

Plants

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This cytogenetic study evaluates the biostimulation potential of the aqueous extract of seabuckthorn fruits (AESF) in plant cells, using the Allium cepa species as a test plant. The effects were monitored both at the macroscopic and microscopically level. The onion bulbs were exposed to the action of different concentrations of AESF (0.5, 1, 1.5, 2, and 2.5%) for 72 h. The obtained results showed the positive effect induced by the aqueous extract on the growth of the meristematic roots, but only at concentrations ranging between 0.5–1.5%, when the average length of the roots had values between 2.51–3.40 cm, which means an increase compared to the untreated control with 3.71–40.49%. Within the same concentration range of the AESF, an effect of intensifying the mitotic activity was recorded. On the other hand, at the 2–2.5% concentration of the AESF, there was an inhibitory effect on the growth of meristematic roots. Additionally, concentrations ≥2% of AESF induced a cytotoxic and genotoxic effect through the occurrence of some chromosomal and nuclear abnormalities in A. cepa cells (sticky, laggards, ring chromosomes, and micronucleus). The obtained results suggest the biostimulation potential of the AESF for plant cells and the possibility of using it as an eco-friendly fertilizer.

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“…In scientific periodicals, there are quite few research articles dedicated to the study of sea buckthorn and its physiological effects, despite the fact that this product has been used in medical practice and nutrition of Asia and Europe for many centuries [23]. However, the nutritional composition of sea buckthorn allows us to recognize this product as bio-functional, which indicates the feasibility of its use in food technology for the products with functional properties [24,25].…”

Section: Discussionmentioning

confidence: 99%

Experimental studies of the effect of sea buckthorn and wheat bran in food on the physiological status of rats

et al. 2020

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The aim of this research paper was a sanitary-toxicological study of the effectiveness and safety of developed functional property products, such as chopped semi-finished products from chicken with wheat bran and shortbread cake with cottage cheese and sea buckthorn, in preclinical studies on laboratory animals. Methods — The effect of new products on the experimental rats was studied using physiological, biochemical, pathomorphological and histological research methods. As a result, it was discovered that the inclusion of foods with wheat bran and fresh sea buckthorn into the diet of experimental animals had a positive effect on the behavioral reactions of rats, the increase of appetite and the rapid growth of animals. Results — The improvement in the metabolic processes physiology of the studied rats was noted in the biochemical and morphological blood parameters. In the experimental group of rats where carbohydrates were partially substituted with cottage cheese shortbread cake and sea buckthorn, a significant decrease in the total bilirubin content was noted; the level of cholesterol in the blood serum of experimental animals from group which received chicken cutlets with bran was 1.4-1.7 times lower than the cholesterol content in animals of the control and other experimental groups. At the same time, statistically significant differences in the number of red blood cells, white blood cells, platelets and hemoglobin level, the activity of alanine and aspartate aminotransferases, alkaline phosphatase and amylase, the level of total protein and the creatinine content were not revealed in the group of experimental rats compared with the control group of rats, receiving a standard diet. The histological data showed that the liver structure of the experimental animals had a more pronounced beam and capillary structure compared with the control group, and the condition of the villi and epithelium of the small intestine showed the positive physiological effect of the studied herbal additives in food technology with functional properties. Conclusion — The research results allow us to conclude that the developed products are functional, intended for the systematic use in the composition of food rations by all age groups of a healthy population, which reduces the risk of gastrointestinal and liver diseases.

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Genotoxicity and teratogenicity of seabuckthorn (Hippophae rhamnoides L.) berry oil

Cited by 26 publications

References 23 publications

Cytokines Driven Anti-Inflammatory and Anti-Psoriasis Like Efficacies of Nutraceutical Sea Buckthorn (Hippophae rhamnoides) Oil

Cytokines Driven Anti-Inflammatory and Anti-Psoriasis Like Efficacies of Nutraceutical Sea Buckthorn (Hippophae rhamnoides) Oil

Cytogenetic Study on the Biostimulation Potential of the Aqueous Fruit Extract of Hippophae rhamnoides for a Sustainable Agricultural Ecosystem

Experimental studies of the effect of sea buckthorn and wheat bran in food on the physiological status of rats

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