Genotoxicity and toxicity of silver nanoparticles and silver ions

Beer, Christiane; Foldbjerg, Rasmus; Dang, Duy Anh; Autrup, Herman

doi:10.1016/j.toxlet.2011.05.175

Cited by 5 publications

(2 citation statements)

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“…Another possible exposure is to aerosol sprays or via inhalation of water droplets containing AgNPs . The toxicity of AgNPs that is responsible for their medicinal use has been investigated, − which is attributed to the toxicity of Ag + ions in aqueous solution, a species that possess antimicrobial properties and is found to react with various biomolecules. − Given that AgNPs can enter the lungs through inhalation and AgNPs may be potentially toxic, it is important to know the impact of ENMs such as AgNPs on the human body but especially the lung, where they will likely deposit when inhaled.…”

Section: Introductionmentioning

confidence: 99%

Evolution of Silver Nanoparticles in the Rat Lung Investigated by X-ray Absorption Spectroscopy

et al. 2014

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Following a 6-h inhalation exposure to aerosolized 20 and 110 nm diameter silver nanoparticles, lung tissues from rats were investigated with X-ray absorption spectroscopy, which can identify the chemical state of silver species. Lung tissues were processed immediately after sacrifice of the animals at 0, 1, 3, and 7 days post exposure and the samples were stored in an inert and low-temperature environment until measured. We found that it is critical to follow a proper processing, storage and measurement protocol; otherwise only silver oxides are detected after inhalation even for the larger nanoparticles. The results of X-ray absorption spectroscopy measurements taken in air at 85 K suggest that the dominating silver species in all the postexposure lung tissues were metallic silver, not silver oxide, or solvated silver cations. The results further indicate that the silver nanoparticles in the tissues were transformed from the original nanoparticles to other forms of metallic silver nanomaterials and the rate of this transformation depended on the size of the original nanoparticles. We found that 20 nm diameter silver nanoparticles were significantly modified after aerosolization and 6-h inhalation/deposition, whereas larger, 110 nm diameter nanoparticles were largely unchanged. Over the seven-day postexposure period the smaller 20 nm silver nanoparticles underwent less change in the lung tissue than the larger 110 nm silver nanoparticles. In contrast, silica-coated gold nanoparticles did not undergo any modification processes and remained as the initial nanoparticles throughout the 7-day study period.

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Section: Introductionmentioning

confidence: 99%

Evolution of Silver Nanoparticles in the Rat Lung Investigated by X-ray Absorption Spectroscopy

et al. 2014

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“…The traditional genotoxic assay, Ames test, was not effective enough to generalize toxicological behavior for silver nanoparticles (38). Comet assay and micronucleus formation assay are more suitable to detect the genotoxicity of silver nanoparticles than Ames test (39). While the mentioned tests are capable of assessing toxicity of silver nanoparticles in vitro, there is scars knowledge about the genotoxicity behavior of silver nanoparticles in vivo.…”

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confidence: 99%

Genotoxicity of Silver Nanoparticles synthesized by Laser Ablation Method in Vivo

Tawfeeq¹,

Kadhim²,

Yaseen³

et al. 2018

IJCMG

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This research was conducted to evaluate three main methods usually used to assess cellular DNA damage in genotoxicity assays. These methods were single cell gel electrophoresis (comet assay), micronucleus formation, and DNA fragmentation assay. Nanoparticles genotoxicity is a subject of compelling immediate action as a result of wide application of nanotechnology in many sectors which in contact with humane health. The mentioned methods were used to assess the genotoxicity of silver nanoparticles in vivo. Silver nanoparticles were synthesized by laser ablation of pure silver plate submerged in double distilled water. The synthesized nanosilver was characterized with UV-Visible spectroscopy and atomic force microscope. After its characterization, silver nanoparticles were injected subcutaneously in to BALB/c mice at 200 µg/ kg BW for two different periods of time, one week and two weeks in daily manner. After the end of injection the animals were sacrificed and their bone marrow cells, lymphocytes, and spleen cells were collected. DNA damage in these cells was assessed using the three mentioned methods. Results indicated that the three types of DNA damage assessment methods were capable to detect the genotoxicity of silver nanoparticles in the treated animals. Spleen cells were the less DNA damaged cells as indicated with the three assays in the first week of injection. Lymphocytes and bone marrow cells was effected in more aggressive manner.

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The Action‐Networks of Nanosilver: Bridging the Gap between Material and Biology

Cao

Qin

2021

Adv Healthcare Materials

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The emergence of nanosilver (silver in nanoscale shapes and their assemblies) benefits the landscape of modern healthcare; however, this brings about concerns over its safety issues associated with an ultrasmall size and high mobility. By reviewing previous reporting details about the synthesis and characterization of nanosilver and its biological responses, a gap between materials synthesis and their biomedical uses is characterized by the insufficient understanding of the interacting and interplaying nanoscale actions of silver. To improve reporting quality and advance clinical translations, it is suggested that researchers have a comprehensive recognition of the "Indications for use" before designing innovative nanosilver-based materials and an "Action-network" concept addressing the acting range and strength of those nanoscale actions is implemented. Although this discussion is specific to nanosilver, the idea of "Indications for use" centered design and synthesis is generally applicable to other biomedical nanomaterials.

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Genotoxicity and toxicity of silver nanoparticles and silver ions

Cited by 5 publications

References 0 publications

Evolution of Silver Nanoparticles in the Rat Lung Investigated by X-ray Absorption Spectroscopy

Evolution of Silver Nanoparticles in the Rat Lung Investigated by X-ray Absorption Spectroscopy

Genotoxicity of Silver Nanoparticles synthesized by Laser Ablation Method in Vivo

The Action‐Networks of Nanosilver: Bridging the Gap between Material and Biology

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