Genotoxicity evaluation of silica nanoparticles in murine: a systematic review and meta-analysis

Li, Li; Deng, Yaxin; Meng, Xiaojia; Chang, Hongmei; Ling, Chunmei; Li, Danni; Wang, Qian; Lu, Tianjiao; Yang, Yaqian; Song, Guanling; Hu, Yunhua

doi:10.1080/15376516.2021.1965277

Cited by 12 publications

(7 citation statements)

References 69 publications

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“…SiNP also induced uterine inflammation in vivo [ 80 ]. Additionally, genotoxicity both in vivo and in vitro [ 81 ] is described with SiNPs < 21 nm and, thus, seemingly harmless Si nanostructures associated to Al and Ca in the typical airborne pollution mixtures compound the synergistic genotoxic and oxidant early placental damage.…”

Section: Discussionmentioning

confidence: 99%

Environmental Nanoparticles Reach Human Fetal Brains

et al. 2022

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Anthropogenic ultrafine particulate matter (UFPM) and industrial and natural nanoparticles (NPs) are ubiquitous. Normal term, preeclamptic, and postconceptional weeks(PCW) 8–15 human placentas and brains from polluted Mexican cities were analyzed by TEM and energy-dispersive X-ray spectroscopy. We documented NPs in maternal erythrocytes, early syncytiotrophoblast, Hofbauer cells, and fetal endothelium (ECs). Fetal ECs exhibited caveolar NP activity and widespread erythroblast contact. Brain ECs displayed micropodial extensions reaching luminal NP-loaded erythroblasts. Neurons and primitive glia displayed nuclear, organelle, and cytoplasmic NPs in both singles and conglomerates. Nanoscale Fe, Ti, and Al alloys, Hg, Cu, Ca, Sn, and Si were detected in placentas and fetal brains. Preeclamptic fetal blood NP vesicles are prospective neonate UFPM exposure biomarkers. NPs are reaching brain tissues at the early developmental PCW 8–15 stage, and NPs in maternal and fetal placental tissue compartments strongly suggests the placental barrier is not limiting the access of environmental NPs. Erythroblasts are the main early NP carriers to fetal tissues. The passage of UFPM/NPs from mothers to fetuses is documented and fingerprinting placental single particle composition could be useful for postnatal risk assessments. Fetal brain combustion and industrial NPs raise medical concerns about prenatal and postnatal health, including neurological and neurodegenerative lifelong consequences.

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Section: Discussionmentioning

confidence: 99%

Environmental Nanoparticles Reach Human Fetal Brains

et al. 2022

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“…HA NPs employed in a dental filling bind with blood proteins, form a complex that is killed by macrophages, and then transferred to major vascular organs, such as the lung and spleen, which shows toxic responses [ 147 ]. In addition, genotoxic and immunotoxic effects were exhibited by silica and zirconium nanomaterials primarily due to reactive oxygen species (ROS) [ 148 , 149 ].…”

Section: Application Of the Nano Dentistrymentioning

confidence: 99%

Nanomaterials in Dentistry: Current Applications and Future Scope

et al. 2022

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Nanotechnology utilizes the mechanics to control the size and morphology of the particles in the required nano range for accomplishing the intended purposes. There was a time when it was predominantly applied only to the fields of matter physics or chemical engineering, but with time, biological scientists recognized its vast benefits and explored the advantages in their respective fields. This extension of nanotechnology in the field of dentistry is termed ‘Nanodentistry.’ It is revolutionizing every aspect of dentistry. It consists of therapeutic and diagnostic tools and supportive aids to maintain oral hygiene with the help of nanomaterials. Research in nanodentistry is evolving holistically but slowly with the advanced finding of symbiotic use of novel polymers, natural polymers, metals, minerals, and drugs. These materials, in association with nanotechnology, further assist in exploring the usage of nano dental adducts in prosthodontic, regeneration, orthodontic, etc. Moreover, drug release cargo abilities of the nano dental adduct provide an extra edge to dentistry over their conventional counterparts. Nano dentistry has expanded to every single branch of dentistry. In the present review, we will present a holistic view of the recent advances in the field of nanodentistry. The later part of the review compiled the ethical and regulatory challenges in the commercialization of the nanodentistry. This review tracks the advancement in nano dentistry in different but important domains of dentistry.

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“…Although SiNPs have been broadly established for uses in biomedicines but their toxicity has not been examined widely. The investigations about toxicity of SiNPs related to time period and quantity are still missing [49] .…”

Section: Discussionmentioning

confidence: 99%

“…The microglial and neuromuscular functions could be affected by SiNPs [17] , [62] . It has been noted that SiNPs cause neurotoxicity when enter the central nervous system by crossing the barriers of brain blood [49] . Moreover, neuroglia and nerves distributing the neurological system can be interacted by these nanoparticles.…”

Section: Introductionmentioning

confidence: 99%