2004
DOI: 10.1016/j.cbi.2004.08.002
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Genotoxicity of acrylamide in human lymphocytes

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Cited by 73 publications
(37 citation statements)
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“…Therefore, oxidant/antioxidant balance is spoiled, oxidative stress occurs and thereby, oxidative damage occurs in cells (1,14,(50)(51)(52). One study found that the level of thiobarbituric acid reactive products had increased signifi cantly in the liver samples taken from the rats administrated with acrylamide in acute dose.…”
Section: Discussionmentioning
confidence: 99%
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“…Therefore, oxidant/antioxidant balance is spoiled, oxidative stress occurs and thereby, oxidative damage occurs in cells (1,14,(50)(51)(52). One study found that the level of thiobarbituric acid reactive products had increased signifi cantly in the liver samples taken from the rats administrated with acrylamide in acute dose.…”
Section: Discussionmentioning
confidence: 99%
“…These results show that acrylamide causes a signifi cant decrease in antioxidant parameters. Acrylamide especially decreases the GSH and GST activity levels of cells, spoils the oxidant/antioxidant balance against the oxidants and thus leads to oxidative damage in cells (1,14,(50)(51)(52)(55)(56)(57)(58).…”
Section: Discussionmentioning
confidence: 99%
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“…They suggested that the DNA breakage caused by AA was associated with the enhanced oxidative stress because of the depletion of GSH, an oxidative defense system (Puppel et al, 2005). Others have also reported that AA generates reactive oxygen species (ROS) that can attack all cellular constituents, including protein, nucleic acids, and lipid, and induces oxidative DNA damage, which is reduced by the spin trap of α-phenyl-N-tert-butyl nitrone (PBN) and antioxidants of vitamins C and E (Blasiak et al, 2004).…”
Section: Discussionmentioning
confidence: 99%
“…Acrylamide did not affect iodination and H 2 O generation in human, dog, and PC Cl3 cells, nor cell proliferation in FRTL5 rat thyroid cell line. Acrylamide also causes positive comet assays in human lymphocytes in vitro (Blasiak et al 2004). DNA damage when incompletely or improperly repaired gives rise to mutations, and mutagenesis is a recognized cause of carcinogenesis (Foth et al 2005).…”
Section: Introductionmentioning
confidence: 99%