Genotoxicity of an inorganic pesticide, copper sulphate in mouse in vivo test system.

Potential Genotoxicity in Copper Sulphate Treated Mice.

“…The Copper, though an essential element in the living system, yet induces toxic effects when administered in excess (Bhunya and Pati 1987, Fiskesjo 1988, Agarwal et al 1990) as reported for other essential elements as well (Sharma andTalukder 1987, Fahmy 1999).…”

“…The broad spectrum activity of copper sulphate as fungicide, molluscicide, weedicide and germicide has led to its extensive use in agriculture and medicine (Epstein andLegator 1971, Sengupta 1976). Informations about the genotoxicity of copper sulphate in mammalian test systems is limited (Bhunya andPati 1987, Agarwal et al 1990), so the present investigation aims to asses the genotoxicity of copper sulphate in mice in vivo test systems using different mutagenic end points. Different dose levels were used in this study ranging from the recommended to the toxic dose.…”

Induction of Micronuclei in Mice Bone Marrow Cells by Cobalt and Copper Chlorides

“…However, there are few studies addressing the genotoxicity of copper in mice. Bhunya and Pati [5] indicated that copper sulphate induced chromosomal aberrations, micronuclei and sperm abnormalities in mice bone marrow cells. It has been reported that copper sulphate induced chromosomal aberrations [2] and it was genotoxic in mice [15].…”

Copper and its inorganic compounds [MAK Value Documentation, 2006]

“…In the bone marrow investigations, performed 6 hours after the second injection, micronuclei were observed in polychromatic and in normochromatic erythrocytes (Bhunya and Pati 1987). The latter observation cannot be related to the treatment of the animals because of the lifespan of normochromatic erythrocytes.…”

“…The predominant aberrations were chromatid gaps, which are not to be regarded as true DNA discontinuities. No details of positive controls were given (Bhunya and Pati 1987).…”