Genotoxicity of metal based engineered nanoparticles in aquatic organisms: A review

Mahaye, Ntombikayise; Thwala, Melusi; Cowan, Don A.; Musee, N

doi:10.1016/j.mrrev.2017.05.004

Cited by 90 publications

(47 citation statements)

References 221 publications

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“…The potential of plant-mediated AgNPs in clinical marketability needs to be assessed in order to ensure their toxicity to mammalian cells. Previous studies have highlighted that AgNPs have ability to induce reactive oxygen species (ROS) that cause DNA damage and chromosomal fragmentation, interfere with protein normal function by affecting the purine and pyrimidine bases, which consequently lead to gene mutation and affect the gene expression profiles [67][68][69]. Therefore, it is highly imperative to determine the toxicity level of the plant fabricated AgNPs in the present study.…”

Section: Xrd Analysismentioning

confidence: 99%

Plant-Based Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Salvia officinalis: Characterization and its Antiplasmodial Activity

2020

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In the present study, an aqueous leaf extract of Salvia officinalis was used to synthesize silver nanoparticles (AgNPs) and characterized with different techniques such as UV-vis spectroscopy, Fourier transform infrared (FTIR), X-ray diffraction (XRD), Scanning electron microscope (SEM), Energy dispersive X-ray spectroscopy (EDX), Transmission electron microscope (TEM) and thermogravimetric analysis (TGA). Subsequently, its cytotoxic effect against human cervix adenocarcinoma (HeLa) cells and antiplasmodial activity against Plasmodium falciparum were investigated. UV-vis spectrum of AgNPs displayed an absorption peak at 323 nm and TEM result revealed it to be spherical in shape with average size of 41 nm. FTIR results highlighted the key bioactive compounds that could be responsible for the reduction and capping of AgNPs and XRD analysis showed its crystalline nature with a face-centered cubic (fcc) structure. The synthesized AgNPs was found to be less cytotoxic against HeLa cells line and demonstrated good antiplasmodial potential (IC 50 = 3.6 lg/mL). Findings from this study indicated that the AgNPs could serve as a template in the development of new drugs for the control of malaria and hence, further study is needed to identify and characterize the potent molecules that suppress the malaria parasite.

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Section: Xrd Analysismentioning

confidence: 99%

Plant-Based Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Salvia officinalis: Characterization and its Antiplasmodial Activity

2020

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“…Additionally, it is possible that ENMs can accumulate inside the nucleus and directly interact with DNA or other genetic material as well as the secondary genotoxicity generated from ENM-induced responses. [211] Genetic damage will lead to genomic mutation, abnormal cell cycle, and cell death. The detailed mechanisms underpinning these outcomes have been discussed in a recent paper, which reviewed the genotoxicity of metallic ENMs in aquatic organisms.…”

Section: Genotoxicity and Reproductive Toxicitymentioning

confidence: 99%

“…The detailed mechanisms underpinning these outcomes have been discussed in a recent paper, which reviewed the genotoxicity of metallic ENMs in aquatic organisms. [211] However, most reported studies continue to focus on pristine ENMs, and overlook the significance of the environmental corona formed on ENMs in natural waters or during interaction with organisms. Thus, there continues to be uncertainty as to the impact of environmental corona on the genotoxic risks from ENMs, making it challenging to formulate conclusions on this relationship at present.…”

Section: Genotoxicity and Reproductive Toxicitymentioning

confidence: 99%

The Crucial Role of Environmental Coronas in Determining the Biological Effects of Engineered Nanomaterials

Wang

et al. 2020

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In aquatic environments, a large number of ecological macromolecules (e.g., natural organic matter (NOM), extracellular polymeric substances (EPS), and proteins) can adsorb onto the surface of engineered nanomaterials (ENMs) to form a unique environmental corona. The presence of environmental corona as an eco–nano interface can significantly alter the bioavailability, biocompatibility, and toxicity of pristine ENMs to aquatic organisms. However, as an emerging field, research on the impact of the environmental corona on the fate and behavior of ENMs in aquatic environments is still in its infancy. To promote a deeper understanding of its importance in driving or moderating ENM toxicity, this study systemically recapitulates the literature of representative types of macromolecules that are adsorbed onto ENMs; these constitute the environmental corona, including NOM, EPS, proteins, and surfactants. Next, the ecotoxicological effects of environmental corona‐coated ENMs on representative aquatic organisms at different trophic levels are discussed in comparison to pristine ENMs, based on the reported studies. According to this analysis, molecular mechanisms triggered by pristine and environmental corona‐coated ENMs are compared, including membrane adhesion, membrane damage, cellular internalization, oxidative stress, immunotoxicity, genotoxicity, and reproductive toxicity. Finally, current knowledge gaps and challenges in this field are discussed from the ecotoxicology perspective.

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“…Вопрос о биохимических механизмах генотоксичности НЧ для различных организмов вызывает повышенный интерес: негативное влияние НЧ TiO 2 ранее отмечалось у рыб [29,36], многощетинковых червей [11], брюхоногих [3] и двустворчатых моллюсков [6,12,20].…”

Section: результаты и обсуждениеunclassified

Генотоксичное воздействие наночастиц диоксида титана на двустворчатого моллюска Mytilus trossulus (Gould, 1850) в морской среде

Kukla

Слободскова

Челомин

2018

mbj

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An increase in the input of titanium dioxide nanoparticles (NP TiO2) into the marine environment can cause unpredictable consequences and create a potential danger to organisms of different trophic levels. Impact of NP TiO2 on the bivalve Mytilus trossulus (Gould, 1850) was studied using the DNA comet method, and the levels of DNA damage were assessed. Shown that 10-day exposure to NP TiO2 at concentrations of 200 and 1000 μg·l-1 leads to destructive changes in the DNA of the gills and of the digestive gland of the mollusks. Difference between DNA damage in two examined tissues was noted. Furthermore, the elevation of titanium content and malondialdehyde content in digestive gland of mollusks was noted.

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Genotoxicity of metal based engineered nanoparticles in aquatic organisms: A review

Cited by 90 publications

References 221 publications

Plant-Based Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Salvia officinalis: Characterization and its Antiplasmodial Activity

Plant-Based Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Salvia officinalis: Characterization and its Antiplasmodial Activity

The Crucial Role of Environmental Coronas in Determining the Biological Effects of Engineered Nanomaterials

Генотоксичное воздействие наночастиц диоксида титана на двустворчатого моллюска Mytilus trossulus (Gould, 1850) в морской среде

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