Genotoxicity of nitric oxide produced from sodium nitroprusside

Lin, Weici; Hou, Xue; Liu, Shengying; He, Yanan; Fu, Junjie; Zhou, Zhenming

doi:10.1016/s1383-5718(98)00014-x

Cited by 30 publications

(12 citation statements)

References 27 publications

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“…According to previous works reporting genotoxic property of NO both in vivo and in vitro [21,22], we found that NO administration induced a significant increase of MN frequency compared with the control cultures, nevertheless it was less than that caused by nicotine. Namely, nicotine damaged more than NO.…”

Section: Discussionsupporting

confidence: 65%

“…Our interest on NO was derived from the knowledge that this molecule was able to modulate the apoptotic process in a manner that appears to be specific to the cell type [27] and to induce DNA damage both in vivo and in vitro [21,22]. For this reason we intended at first to investigate the effects of exogenous NO on HGFs, comparing them with nicotine ones.…”

Section: Discussionmentioning

confidence: 99%

“…NO can induce DNA damage by the direct interaction of RNOS, formed from NO and ROS, with DNA structure or by production of genotoxic species such as alkylating agents and hydrogen peroxide [20]. Genotoxicity associated with NO has been reported in the NO-producing cells [21] and in NO-donor treated cells [22].…”

Section: Introductionmentioning

confidence: 99%

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Evidence for the role of nitric oxide in antiapoptotic and genotoxic effect of nicotine on human gingival fibroblasts

Argentin

Cicchetti

2006

Apoptosis

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Resistance to apoptosis is essential for cancer survival and plays a critical role in carcinogenesis. Growing evidence suggests that nicotine can act as a tumor promoter, impairing apoptotic process in certain types of human cancer cell lines. Our previous study revealed in human gingival fibroblasts (HGFs) a concomitant antiapoptotic and genotoxic effect of nicotine, manifested by the attenuation of staurosporine (STP)-induced apoptosis and the increase of micronucleus frequency. The present report provides evidence that nitric oxide (NO) is critically involved in these actions. In vitro treatment with sodium nitroprusside as NO donor showed that NO produced similar effects as those observed with nicotine: it caused DNA damage and partially prevented apoptosis induced by staurosporine. Exposure of HGFs to nicotine, at concentrations similar to those found in the blood of habitual smokers, leads to the production of NO associated with the induction of inducible nitric oxide synthase (iNOS) expression. Experiments using an inhibitor of iNOS, N-monomethyl-L-arginine (NMA), together with nicotine confirmed the involvement of NO in the drug action, abrogating completely cell death and a good part of the genotoxicity. Finally, we show by different approaches that the inhibition of cell death by nicotine through NO release is related to modulation of caspase-1 activation.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

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Evidence for the role of nitric oxide in antiapoptotic and genotoxic effect of nicotine on human gingival fibroblasts

Argentin

Cicchetti

2006

Apoptosis

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“…Several reports have shown that NO is mutagenic in vitro (Lin et al, 1998). Epidemiological studies have suggested that several human cancers, such as gastric cancer, are associated with chronically elevated NO levels in infections (Liu and Hotchkiss, 1995).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant activity and antiproliferative action of methanolic extract of Geum quellyon Sweet roots in human tumor cell lines

Russo

Cardile

Lombardo

et al. 2005

Journal of Ethnopharmacology

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“…Recently, DNA damage, caused by reactive nitrogen species (RNS), including nitric oxide (NO) and its derivatives, such as peroxynitrite (ONOO − ) and nitrogen dioxide, has been discussed in relation to the association between chronic inflammation, genotoxicity and carcinogenesis [21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Genotoxic effect and nitrative DNA damage in HepG2 cells exposed to aristolochic acid

Wu¹,

Jiang²,

Cao³

et al. 2007

Mutation Research/Genetic Toxicology and Environmental Mutagene

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Genotoxicity of nitric oxide produced from sodium nitroprusside

Cited by 30 publications

References 27 publications

Evidence for the role of nitric oxide in antiapoptotic and genotoxic effect of nicotine on human gingival fibroblasts

Evidence for the role of nitric oxide in antiapoptotic and genotoxic effect of nicotine on human gingival fibroblasts

Antioxidant activity and antiproliferative action of methanolic extract of Geum quellyon Sweet roots in human tumor cell lines

Genotoxic effect and nitrative DNA damage in HepG2 cells exposed to aristolochic acid

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