Genotoxicity of plumbagin and its effects on catechol and NQNO-induced DNA damage in mouse lymphoma cells

Demma, Jemal; Hallberg, Karl; Hellman, Björn

doi:10.1016/j.tiv.2008.12.007

Cited by 43 publications

(23 citation statements)

References 39 publications

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“…Furthermore, induction of ROS may lead to DNA damage [27,30,34]. In line with this, our study also showed that plumbagin treatment induces DNA damage.…”

Section: Discussionsupporting

confidence: 87%

Plumbagin alters telomere dynamics, induces DNA damage and cell death in human brain tumour cells

Khaw

Sameni

Somasundaram

et al. 2015

Mutation Research/Genetic Toxicology and Environmental Mutagene

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“…Furthermore, induction of ROS may lead to DNA damage [27,30,34]. In line with this, our study also showed that plumbagin treatment induces DNA damage.…”

Section: Discussionsupporting

confidence: 87%

Plumbagin alters telomere dynamics, induces DNA damage and cell death in human brain tumour cells

Khaw

Sameni

Somasundaram

et al. 2015

Mutation Research/Genetic Toxicology and Environmental Mutagene

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“…Naphthoquinones are known to induce microbial death through the ability to complex with nucleophilic amino acids of bacterial proteins leading to loss of function [13]. The antimicrobial mechanisms of plumbagin include interaction with DNA leading to its damage [14] as well as oxidative effects in prokaryotic cells lacking superoxide dismutase [15]. These could also be the possible mechanisms of action of diospyrone and crassiflorone, as they all contain the juglonyl ring.…”

Section: Resultsmentioning

confidence: 99%

Diospyrone, crassiflorone and plumbagin: three antimycobacterial and antigonorrhoeal naphthoquinones from two Diospyros spp.

Kuete

Tangmouo

Meyer

et al. 2009

International Journal of Antimicrobial Agents

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“…In the comet assay, using mouse lymphoma L5178Y cells (Demma et al 2009), plumbagin was able to reduce the catechol-induced DNA damage, suggesting its role as an antioxidant at low concentrations. Plumbagin has also been reported to inhibit ascorbate and NADPH-dependent lipid peroxidation in rats that were fed plumbagin (Sankar et al 1987).…”

Section: Plumbaginmentioning

confidence: 99%

Role of Novel Nutraceuticals Garcinol, Plumbagin and Mangiferin in the Prevention and Therapy of Human Malignancies: Mechanisms of Anticancer Activity

Ahmad

Padhyé

Sarkar

2011

Nutraceuticals and Cancer

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Nutraceuticals from natural sources have been investigated for their putative chemopreventive and cancer therapeutic properties for the last few decades. The interest in these compounds is in part due to their pleiotropic effects and relatively non-toxic nature. A large number of such nutraceuticals are under detailed investigations worldwide but most of them suffer from the lack of sufficient bioavailability in humans. The identification and characterization of novel natural compounds with sufficient anticancer potential is therefore an ongoing process. This article is a summary of anticancer activity of three such novel nutraceuticals, namely garcinol, plumbagin and mangiferin. These compounds have shown promising biological activity in preliminary studies by targeting multiple signaling pathways. In particular, it seems that the inhibition of NF-κB pathway is one of the major mechanism through which these compounds exhibit their anticancer and apoptosis-inducing effects. The data on their anticancer activity is just emerging and the information on their bioavailability is still insufficient to predict their future application in the clinical settings. In this article, we have surveyed the available literature to summarize the mechanisms of anticancer activity of these three novel nutraceuticals. We also discuss the challenges and possible solutions to realize the dream on the translational potential of these compounds into clinical practice for the prevention and/or treatment of human malignancies.

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Genotoxicity of plumbagin and its effects on catechol and NQNO-induced DNA damage in mouse lymphoma cells

Cited by 43 publications

References 39 publications

Plumbagin alters telomere dynamics, induces DNA damage and cell death in human brain tumour cells

Plumbagin alters telomere dynamics, induces DNA damage and cell death in human brain tumour cells

Diospyrone, crassiflorone and plumbagin: three antimycobacterial and antigonorrhoeal naphthoquinones from two Diospyros spp.

Role of Novel Nutraceuticals Garcinol, Plumbagin and Mangiferin in the Prevention and Therapy of Human Malignancies: Mechanisms of Anticancer Activity

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