Genotoxicity of quercetin in cultured mammalian cells

Antioxidant evaluation of O-methylated metabolites of catechin, epicatechin and quercetin

“…Different in vitro studies reported genotoxic effects for quercetin associated to the pro-oxidant activity of reactive electrophilic quinones resulting from its oxidation [42,43], although in vivo carcinogenicity has failed to be demonstrated for quercetin. It has been recently shown that methylation of a catechol hydroxyl group considerably attenuates the cellular implications of the pro-oxidant activity of quercetin [44].…”

Quercetin in Cancer Prevention and Therapy

“…Maybe, possible suggestions could come from considering two important hallmarks of quercetin as a chemopreventive substance, namely, that it is a genotoxic compound and a phytoestrogen. For example, as a moderately and well tolerated genotoxic compound in vivo, 43 quercetin belongs to that wide range of plant-derived molecules that contributed to the conservation, during evolution, of p53 superfamily, having the task of inducing apoptosis in response to xenobiotic genotoxic agents: 44 current strategies in targeting p53 in cancer have recently been attempted. 45,46 Deepening the role of plant-derived products from dietary intake in the context of the molecular regulation of apoptosis may result in a possible comprehension of their role in animal cells.…”

Protective Effects of Quercetin and Its Metabolites on H2O2-Induced Chromosomal Damage to WIL2-NS Cells

“…[4][5][6][7][8][9][10] Furthermore, quercetin has been reported to be carcinogenic. [11][12][13] Damage to DNA or chromosomes is important because the damage influences cell functions, resulting in various diseases, and aging.…”