2009
DOI: 10.1016/j.toxlet.2009.07.003
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Genotoxicity of sodium arsenite and DNA fragmentation in ovarian cells of rat

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Cited by 24 publications
(9 citation statements)
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“…Dose, concentration, exposure time, distance affects the arsenic induced genotoxicity. DNA damage has been detected in ovarian tissue in a dose-dependent manner [29]. Similarly higher extent of DNA fragmentation has also been reported in different communities of San Luis Potosi State [37] and in different schools of Mexico [36] located at different distances from arsenic smelter area.…”
Section: Discussionmentioning
confidence: 55%
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“…Dose, concentration, exposure time, distance affects the arsenic induced genotoxicity. DNA damage has been detected in ovarian tissue in a dose-dependent manner [29]. Similarly higher extent of DNA fragmentation has also been reported in different communities of San Luis Potosi State [37] and in different schools of Mexico [36] located at different distances from arsenic smelter area.…”
Section: Discussionmentioning
confidence: 55%
“…There was only single study evaluating DNA damage in ovarian tissue of rat [29] and in liver of fish [39] exposed to different doses of arsenic and indicated the increased extent of DNA damage with all doses, specifically at high dose levels. In studies of current review, arsenic concentration was measured in blood, liver, ovary and water.…”
Section: Discussionmentioning
confidence: 99%
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“…In addition to in vitro studies, research evaluating arsenic‐induced chromosomal aberration, sister chromatid exchanges, and hypermethylation or hypomethylation of DNA in mice, rats, fish, and humans has been conducted . In the present work, arsenic treatment caused increased levels of DNA damage in rat mononuclear leukocytes, whereas boron (particularly at doses of 10 and 20 mg/kg) showed antigenotoxic effects and protected cells from DNA damage with its cell protective effect …”
Section: Discussionmentioning
confidence: 83%